Sickle Cell Disease questions with correct answers

Sickle cell disease represents a group of inherited RBC disorders - Answer RBCs, which are normally rounded and mouth, take on a sickle (c shaped) appearance and become hard and sticky As the abnormal cells travel through the blood vessels they stick together, creating a clog the blocks the flow of blood (vast-occlusion) Decreased flow - O - deprivation - tissue damage - pain Sickle cell anemia is the most common form of SCD - Answer Autosomal recessive disorder resulting from a single amino acid substitution in the gene for Hb Normal Hb A is partly or completely replaced by abnormal sickle Hb S Both parents must have an abnormal Hb trait to have SCD Both parents have trait- 25% EACH baby will have SCD RBCs live 90-120 days providing body with all O it needs - Answer Bone marrow makes plenty of new RBC to replace ones that die off Sickle cells only live 10-20 days New RBCs constantly produced, marrow can't keep up with rate of cell destruction (hemolysis) Baseline Hb levels in patients with SCD are usually 6-7 g/dL compared to 12-16 - Answer Usually able to perform ADLs but show intolerance for exercise Severe or long lasting anemia can damage all parts of the body (heart, brain, bone, lungs, kidneys, spleen, skin, tissues) Complications of sickle cell - Answer Pain (SCD), ane