OW.\ne, .,.i^ de voornao\rn=le- sen!inetce\\en Q-n we-\<<-
\y;";.t"*;...{r^ed'lo'!ore'n S*e-\[en ze
"y 1
S en\ine\ ce-\\en ac\irl z(eA ele onls\eki^9
s{Lc-c\ig e^ Zy^ Uooral
micro - orgcl.^r'soAeA vre-\
&o,nt.,,e-ai3 oP p\aa\se-n t\)ctGr Io'ngS
(nli\f re-re^ a ADft- s\e.t5e\, SV S ,,o^i\or.a!'-
lichqooa pr.te(en he
f a'\o-rrutines '
s;"It;t. Le- he'<e^non fAltPt' DAI'tPs
o Fag.n , /has{ ce,lten eq dend, ilr'sche-
D e- Voorno.ooas\e ?4^ fnacr
s\ e<ing5a^ecl' a\or en vrg '
Cet\eo . Ze S\e[\en lnf
\ M A CRo tAGe Nl (o*c. Kt^p I le't ccL[eo ' Langn.Ao.^'s CeLlen , (\,'cr6l gt,'a)
-x r.p,orc.lf c.\ sne\ 9e?'odt"ceerd'
z ind*ce-e-r) Sac,"ren me.\ IL-L Uorcrncler,ngec\ inu&Sc.^[airq
-TNJf
gnd'o \hee\ celten (oc-rhoog d e o d.he-sie- , hi g ral,'e , (4^\( eKKing
Q-r\ ctc\iui\ei\ uan \,.lBc's
d-u' enret efll".t op certen
I wo.o_.
'IL- 1, / d.irq.q Confcrci- /'r€e r.5
\ tL-1oc +bepe..rle hoe.u<.e,(he-id., rqe,r.'br (&o geb
ooot.-^
)
tt--1p ") inoc\iel pro- eiwi\ + g"acFiueerd d.oor caspase_1
'lL-6:Produ,.cfie urordl gesl,'r,,rt_r\ee_rd, d.oor lL-1 e-n rNF-x
\ Gc\iuo.\(e. WBc
\ S\irvru\e-e.\ AS produ.clis
) k oo. \s onl ,.^-l iK<e\r'n or
) uorn^.ing &c\-.le Fo/" e,r.^.rr [\en
" lL- d . Ir ex\er,t\.., f,'e,[e",
o cro. o
. U GSo a_c \ieu-e_ fto\ecur\es I
> Se,rine pro\easen Co. a. KctL[iccei'.'e-)
) o aso a-c\i.ue \ip ide.n ( CosFot.paseo) I Ieuto\riene,s
,proslo.g\and,,npJ
t c e ll[r',J en eA t
-) He s
. Tl.J t -or , lL.- 6 , 11- - d Ud.so acf ieUe fao\ec,,.,t\eS; Se rr.A? groleasen enl
' h; s\ or"rin e' i
_i O€AJDR\T\ SCI-IE CTLLLK}
' -d, tL- \2 , fru l- c<
'1
TN Fir( , lL- 5 e/\ tk 1 scLrneo Tor1e-i uoo r :
t,rlorrx\Q
- \oKor.a\'. roodh.,'c[, Zyuet\i ^q t ?V'^,
SYs\ e-olisch: su\oje.\,'e-F "2,'eKle geuoe( en Koor\son\wirxetirfg
-,
,f^ Besp re. e.K d'e- Kenrn erKen V a-n ee-n o.c rr\ e onlsFe<ing an
Y) w e-\<e fi e.cl.ia.\o re.^ cLeze- V eroor e-orke-n
Kaoc^e(Ken : Ioxc^a[ rOoo\heid Lrwbor) , Zu'oe\\'n9 C\urnor), Wo'rr"r\e
(cc.\o"), PE" (do\or)
-+ &er)rtEP cloor uasod,;\af c^\i e
(oo< q!9-9[_l9 en :gIts)
> TNf -ot + ll-a + \L- 5
) U GS oo'c\iev€ 0lo\e- ct't\ e S ?
Se-rO\oAinq (<naagdioren lgrote- ha'b'uo.-tt)
. ar\Aines: hiS\ar,rinQ ,
.pep\ides:3e(t'ne fro\ecsen, P(%fl
, \;g;den : \eu<o\rr eoe s, (tos\qgl.o'ocliAes, p\a\e\el -ctclivaling [o.to.
deze Ur-rorclen O{gges\e\d cloor Senl.Oe-\ceLten u\ro'nAer-r Z?
gLoc I iu eecC t,oordeo doo., b iod.ing \-, Gn FAt-{ps / DAIL?S
cle edi aFor 9^ Ku-nneo oo< ee^ sy s I uvt;5 atn e-0Cecl h ebb
r4
""
? l<o c,. \ S Cfnt t^r i<< etr'nq
4 a\geo^cne- <..r'ek\e f sible ct;e I )
, ute( uerschiLte-nd.e
de uie.r
We-\<e- ZVn de. Ue S)o-ppea Uan (a9 o cV l-os e- en
\ag cle I orc\ore,n 'rr\ dt e tg oten : Fago cy Fo s e- ZorgeA tJoOr
d.es!r .rcyie v o-n hel P oFho ge-eo
o ucrn
CFIEI'lorAxrS . Cac[or e-n d.ie urgKor,rre-n bg uueeFse\beschc.d-r'eine e\er,,,enie..''
de iorr-rwi,r^(esPons, Co.l arel aF<c,n^.stg uan bcrc{oi,.//pa\hogeoeo
Uorln en e-e^ ont die lag. cyl'ec,. uotgeo rlac^. ote p\e< Ucr^
$rctd.r
oc\Fs I e<inq /, Cec I iq
+ nout\.of .t.",-io"]." tiil hel ttoed 3e'Qcr.^;z\ee-rd trcordao \er,^rg\
",
f^@ '€,{\ ree.ds io de t'^'reeFse'\s CLanr"';eZtg zg'o
bago..o'\cle- Y\nediQ[oren Iaci['lglgt"' d.,f a c) h r-'- Vas6d;Ia-Falie,
be schi kKen recep\oreq og h..rn ce[oppr-rv\aK c1,'e
@AoHgs 't ' lagocgleo
in\erctc[ies kttnne n ctO'r\9*tt.. Pre[ elevreo Ie-O op he-{ Kg.ruLo,F Uan
he\ pcrlho ge-e^ (. 3 \e-clines : eiwi\\sn d.'e- in\er-aclies gorn-. M e-l
Vre-eo.o \ d e 5trlk e.. s\r ic\
u'r er)
shers be-Uo
-i d.-n"-w'
rdzcd .-r oPsonisa'lie (opsoor'AeS\
* ad,hesie u.ro.cj.\
OOpr.lA[€ . gee^ en lago cyt Zor X) Voor Zea
.,n\e65rc\ie. \trsSeo po.lho
he-. Sc-k,11g;nq r./&n he\ c lo skeet (ctcr ing C''(oo"n-''t g,.',) ,
de lo.go(:l)
)
OCnra r fv.\ C,.\a he-\ LAia(e de- pathcgeen ) de"c^'r.'u.." Jerscv'\e\\eo
[,u6r.61rd.oor Q.ecx Ues ixe\ Seuormd. U-rordl
: lo9 " Soory\ -+ lotsion eor]
Vervb\genS 04e1 (ysoSoo'ran, laSo(ysoSoorvr
t fro\onpomPe.o in he\ fhec,.r\orctan uan cla uesi<e'l fona.pen P.olooen nqcrr
binnen ) wer z''.t-r in9 t o al ioo.cler io S\ ai is ch /l>"cler, c,' d,ac,l <an Zln
o resp,rato,ische bt^,s\: Ueru.Jer<ing Uan
$role hoe.ueelhede-n lol loxisctr^,e
ztr-tr-vs\ofde.ivo"\on d.ie he-i palhogee,-, oxydereo
, 'pothojqe^.r
in me.,. Lcaqn uan de
- ooK foxisdne S\rksloQdecivaron /
. posi\ie-f $e\aden pe,pliden zoa\s de-Ne",$rn€-5 q:orde-., a-o.r.g.-troc[,f v,i:t heJ
\ySoSoon".r e-n Ku"nnen gorien Uorryaerr -) kc.n (a,de", [ol OSoaol, Sche tySe
. in l.lsoso&\er\ f,l[eo drUef se eAzVrv'.es (r'g \9soz'y*eJ d,'q opl,rnaa{ ujerKe.)
%g de Lure Pl-l voc\ he-1 fagolyso5oona
. Cor-rpon e^\e^ in he..t Cogolyrosoo^^ 9aA^ i'A coMpel,lrg &el lc.clo.e n d,q
pathoge^e-v^\ nodg h obben oM le oUer\ e-\/en /verrnentifVt<ld,gen
,@-!e.L.ce uerschi\\end.- o.c\i vo,\ ie.urege^ van 661'np\ er^oo+ ui+
(Al Kr-Rssrxe,rrrvnrre
o,n\i7s\ollen he-.[.\e."' op an{igeneo op hel opperv(a< vaA pa[hogeneo
I del-<- o.nlis\"ffen k(rnAe.o \eideo Io] connp\en^en] aclival ie
) CL cornplsy bindl ao..' L dorqeia uaa anlis!'olleo
i = CL1. = $ Strbt^n;l,s J rqoe.l rhe\ rqinsleos 2- lgG aniis loFCen
' I in\erage(en otu1 ge.qcliv e,erd l-e" worcten n tg /1 rs ook oK) en don
L = c !, ;
,
^ Cl, ', c1v kn rp I a, ac\ ivarie ee^ stule vqn C:*,
) CLs v er<nip\ C\ (aan wez,3 Seru^r e.^ t,'chao.rra5t,[6s{.5l.oCfqi) 1.1 Ceoen C\,
-r 'a.' du.\ toordl lypisch ucagestelcl ierurgt /bt lTp,sch btyt] plor<en
og he+
p a\h o gee^
'c' tyn u o"cK b.tong rgKe ,cy1fni.r no - (egr^taI ore".
'b' ?el[en de cctsca.dc r.roor*
i C1q -;korvr{ los
hech\ aa^ cgu , cls spr;rst c2
'---s'cz
- . uvLlo
\ rro+ bry t+,prakKe^ aG^ cqt
lr = klassiexe C3 converl-ase -) Uerrnipl c3 lol c 3cn en c3t
-) nr,t h.t .1" e-o^ &rb-dal,$ conaptel a Cql"zb3t, ktassiere C3/Csconuer\ose
J uer<n,p\ C3 (eefr'ciJn\er don CqurZ6) .n CS
-) uee-\ C3b xoc,r\ uog eeo hech+ r-.ras{ a6n pathogeen =opson;sal,./
+ CS r= 97: _-> larm\n crte- (on^ p\etne n I act ,'u c,f io
L >b
-,
C\ en C3 loeuo"[\en ee-n in\erne fh,o - esle.r uq.lcinding Cie hoo, b^,len
korn\ ' c,.ls 7e- utOrdeo uer<nipl -) deze- 7l^ hoq (eqctle{ en feagere.o
r,rra\ eiu.-,ilten zA St-.tire-rS q hnf opPerutoK UcLn het pelhoQee-r: t,tiaatdoor
ze o.\s he,l ty'ar e' uasft\uu%
lhlo - €s{e. ve.brnd.rng , RASp-'
[g] t{Bl ..,(\OLEI'ALUT ACTIV/cTII
Suirers\rur-c\wren Oe het oppervta< Uan he-t pcrlhogeen infer nnet
^qe-(e-^
r otn^oSe binclend Lec{ine (l{AL) : een d-cu}e Ca.se e(uri+ d.,e tydens eet
on[s\e<ingsreo.c\ie- t,h v. d.e [eusr geaorrvtd e.o Urgge.[o.Je,n ulorc{.1
o ARL beslqc.\ ps1 Zoals Cal uil 6 sq\<eohedeo
' 2c is g.@cr ,oo.*fgaonde Opsooisa\ie UcL^ hel po.lho yee^ C[-oo. &n+r': folGrr
ne\ z-oct\S ClrL is A{AL Letxens gec{sso cieerc,l rqet 2- kopgerr [/on 2 pr6'l scrsgo
, C1\ -- MBL
, Ca', = HAS?- 1" (Iou a5soc,ctleA se-,i^e*.gco\"ote)
, C1= = |IASP-2
de fesl votgt a"ts Ktassie<
, ALTE RtuATtcVE ao MPLEI'{ENTACr v<l 116
[al I
rneeS\9eUqqrtgxe*"9:heef+ge.e^WSpec,frere,l,ig3er'nod9enKQo
Spon{c.o.n ge-o-c)iuee..c[ c,oordetr.
Cj sg\lIsl SocnS Spontaotn in C3o. ec\ C3b c".r o.o./ tg LAa Zl cA Zctt uas|-
he..h,\ en a.a-.. h e,| r\ee* ct;chls I bgzynde c€[o f pervla< Cpaihogeeo fr\orqr
pote.\\ iee-[ oox tich a.ctrnsaigen cel )-
C ]L uorru^,\ brn d;og:plaqts uoor Cacto. B -? word\ $e<-n,'pl doot Serwftr
pro\ ecrse 6actc'r D ioi Bq en Bt
*i Ro t.=rorc1\ Uer uug dercl , Bb ttgh uas\9el''..[',] cr'o'n CgU = C3 tBt
= he-\ a[terna\iev< C3 conue'r\o'se-
+ ry ha\ o?peru\a< uaft hef polhogee^ 7a.l C,+ corvrplev LJaaK geslab;l;seet,J
(,rrord.en doo.. Fact-or ? (propetd"ine) , op {.,'c\raamseigen ceJ[en t^lord'l
d.i I cor^p\ ex ech he r Sn e( on [cn an I et d
? rnip\ (3 \o{ C3o e^ CiL, *- C36 b${+ p{atteo -1 C3t2f5b
= he-[
e\lero o"tiev<- C\tc5 coouer{ase-
9 ces\ is helze.\ldz a[s de- k[o.ssi ere r-,tle3
[O -l-eR f-l, l'., olg Cottnp.t.mepra c- tv,q-r,e
dl\ [aois\a d.ee,\ uan de- Co.scade \'S (dentr'g6 \JooY A, P" eo C
- C5... en CS b btg',e,o beiden in optossrn3
, CSb 7a\ eersl loinde", Mel C6 eA dagLrna ook C7., Cd ?-n Cg
) na bind;ng C7 (c asb 6l) zo.r het corr,rplex uos lhechleo 51cLo opperutat
uo-ft hei palho q"en
-? dan bind"\ cB ( CS6 6?s) , d.zze zorgl Uoor
= lransrvle-r,,\br^. aire-
uer an ker r'!]
brndin9 uo-q d"ruerse C9', die dool.hon-, he[ et\^b,non
?Y".yotgeos
pane\e ete,. en ee-^ r\
c,'[rn dervar^^ige por re- uarn4en (N- <o nm
) zctrg\ uoc,r osr4olr sch e tgse eo\h"ogn.n Zruett op) a)
+ de- por i e- = }aorvtbrane allact conalrex op /4Ac
u&a< zgo f\eerdere ltAc'r nodig oM ca(dmd he. \tecoo(znkeo
, Eto, .y^ d"e g"rolgen van Corvtplernenlq.livot;e?
o U o r nning HAC s -- oscno\ i sche [Ys e
" oPsonisa\ie (o.cu c:a)
, 'a' d.ee\\Jes t-,tiaaruo.n e( Uer5ch,llend.e, innrnunoregut(er endz lu.nclr'es
hebben
'Lorlz,a uoor .
' n^c(s l ce-l d-egro..Crulal,'es ( his[anain<- koo^{ u.g)
. Uo.hoogdo U&sctr\a,,
e ()a(r eabit, le_, I
. g\odd. e Spiercon\rc^c\iq
. GC\iv al ie pr ctCroCag e-o
' s : op Ue.c5sh,ll.end. z irutMuwn cet[en
Cho$^o \ crxr
' U Qr* y del. eo VaA t'Mfnwwc\ olp-> u I C. b\ o e d b oo. n
a_oo.\ ple-xe-o
urr^ ."1 C-oo-\
\
(uu an\ d,'e- Kunne n Vagt Koyren e.'Ileo en chronr sche on t-s I eKr'n9
usroorzqKen ) -+ Qeopsol-ri seerd /Vlet C3b _> ebC A ob!e., h Ie.
(acep\66 Uoo(
-t \ro.nspor\ pLotar \euer/ort, tl
. in\ . 69\ ie M e+ d iuer se cr.nCe r e @srt-r1.n) cos cade s Zoo.ls
r. :
' b\oed s\o\lrh9
.[;;r,no\y6e
' uorr',r;n g uGn Ktnine 5
\y;";.t"*;...{r^ed'lo'!ore'n S*e-\[en ze
"y 1
S en\ine\ ce-\\en ac\irl z(eA ele onls\eki^9
s{Lc-c\ig e^ Zy^ Uooral
micro - orgcl.^r'soAeA vre-\
&o,nt.,,e-ai3 oP p\aa\se-n t\)ctGr Io'ngS
(nli\f re-re^ a ADft- s\e.t5e\, SV S ,,o^i\or.a!'-
lichqooa pr.te(en he
f a'\o-rrutines '
s;"It;t. Le- he'<e^non fAltPt' DAI'tPs
o Fag.n , /has{ ce,lten eq dend, ilr'sche-
D e- Voorno.ooas\e ?4^ fnacr
s\ e<ing5a^ecl' a\or en vrg '
Cet\eo . Ze S\e[\en lnf
\ M A CRo tAGe Nl (o*c. Kt^p I le't ccL[eo ' Langn.Ao.^'s CeLlen , (\,'cr6l gt,'a)
-x r.p,orc.lf c.\ sne\ 9e?'odt"ceerd'
z ind*ce-e-r) Sac,"ren me.\ IL-L Uorcrncler,ngec\ inu&Sc.^[airq
-TNJf
gnd'o \hee\ celten (oc-rhoog d e o d.he-sie- , hi g ral,'e , (4^\( eKKing
Q-r\ ctc\iui\ei\ uan \,.lBc's
d-u' enret efll".t op certen
I wo.o_.
'IL- 1, / d.irq.q Confcrci- /'r€e r.5
\ tL-1oc +bepe..rle hoe.u<.e,(he-id., rqe,r.'br (&o geb
ooot.-^
)
tt--1p ") inoc\iel pro- eiwi\ + g"acFiueerd d.oor caspase_1
'lL-6:Produ,.cfie urordl gesl,'r,,rt_r\ee_rd, d.oor lL-1 e-n rNF-x
\ Gc\iuo.\(e. WBc
\ S\irvru\e-e.\ AS produ.clis
) k oo. \s onl ,.^-l iK<e\r'n or
) uorn^.ing &c\-.le Fo/" e,r.^.rr [\en
" lL- d . Ir ex\er,t\.., f,'e,[e",
o cro. o
. U GSo a_c \ieu-e_ fto\ecur\es I
> Se,rine pro\easen Co. a. KctL[iccei'.'e-)
) o aso a-c\i.ue \ip ide.n ( CosFot.paseo) I Ieuto\riene,s
,proslo.g\and,,npJ
t c e ll[r',J en eA t
-) He s
. Tl.J t -or , lL.- 6 , 11- - d Ud.so acf ieUe fao\ec,,.,t\eS; Se rr.A? groleasen enl
' h; s\ or"rin e' i
_i O€AJDR\T\ SCI-IE CTLLLK}
' -d, tL- \2 , fru l- c<
'1
TN Fir( , lL- 5 e/\ tk 1 scLrneo Tor1e-i uoo r :
t,rlorrx\Q
- \oKor.a\'. roodh.,'c[, Zyuet\i ^q t ?V'^,
SYs\ e-olisch: su\oje.\,'e-F "2,'eKle geuoe( en Koor\son\wirxetirfg
-,
,f^ Besp re. e.K d'e- Kenrn erKen V a-n ee-n o.c rr\ e onlsFe<ing an
Y) w e-\<e fi e.cl.ia.\o re.^ cLeze- V eroor e-orke-n
Kaoc^e(Ken : Ioxc^a[ rOoo\heid Lrwbor) , Zu'oe\\'n9 C\urnor), Wo'rr"r\e
(cc.\o"), PE" (do\or)
-+ &er)rtEP cloor uasod,;\af c^\i e
(oo< q!9-9[_l9 en :gIts)
> TNf -ot + ll-a + \L- 5
) U GS oo'c\iev€ 0lo\e- ct't\ e S ?
Se-rO\oAinq (<naagdioren lgrote- ha'b'uo.-tt)
. ar\Aines: hiS\ar,rinQ ,
.pep\ides:3e(t'ne fro\ecsen, P(%fl
, \;g;den : \eu<o\rr eoe s, (tos\qgl.o'ocliAes, p\a\e\el -ctclivaling [o.to.
deze Ur-rorclen O{gges\e\d cloor Senl.Oe-\ceLten u\ro'nAer-r Z?
gLoc I iu eecC t,oordeo doo., b iod.ing \-, Gn FAt-{ps / DAIL?S
cle edi aFor 9^ Ku-nneo oo< ee^ sy s I uvt;5 atn e-0Cecl h ebb
r4
""
? l<o c,. \ S Cfnt t^r i<< etr'nq
4 a\geo^cne- <..r'ek\e f sible ct;e I )
, ute( uerschiLte-nd.e
de uie.r
We-\<e- ZVn de. Ue S)o-ppea Uan (a9 o cV l-os e- en
\ag cle I orc\ore,n 'rr\ dt e tg oten : Fago cy Fo s e- ZorgeA tJoOr
d.es!r .rcyie v o-n hel P oFho ge-eo
o ucrn
CFIEI'lorAxrS . Cac[or e-n d.ie urgKor,rre-n bg uueeFse\beschc.d-r'eine e\er,,,enie..''
de iorr-rwi,r^(esPons, Co.l arel aF<c,n^.stg uan bcrc{oi,.//pa\hogeoeo
Uorln en e-e^ ont die lag. cyl'ec,. uotgeo rlac^. ote p\e< Ucr^
$rctd.r
oc\Fs I e<inq /, Cec I iq
+ nout\.of .t.",-io"]." tiil hel ttoed 3e'Qcr.^;z\ee-rd trcordao \er,^rg\
",
f^@ '€,{\ ree.ds io de t'^'reeFse'\s CLanr"';eZtg zg'o
bago..o'\cle- Y\nediQ[oren Iaci['lglgt"' d.,f a c) h r-'- Vas6d;Ia-Falie,
be schi kKen recep\oreq og h..rn ce[oppr-rv\aK c1,'e
@AoHgs 't ' lagocgleo
in\erctc[ies kttnne n ctO'r\9*tt.. Pre[ elevreo Ie-O op he-{ Kg.ruLo,F Uan
he\ pcrlho ge-e^ (. 3 \e-clines : eiwi\\sn d.'e- in\er-aclies gorn-. M e-l
Vre-eo.o \ d e 5trlk e.. s\r ic\
u'r er)
shers be-Uo
-i d.-n"-w'
rdzcd .-r oPsonisa'lie (opsoor'AeS\
* ad,hesie u.ro.cj.\
OOpr.lA[€ . gee^ en lago cyt Zor X) Voor Zea
.,n\e65rc\ie. \trsSeo po.lho
he-. Sc-k,11g;nq r./&n he\ c lo skeet (ctcr ing C''(oo"n-''t g,.',) ,
de lo.go(:l)
)
OCnra r fv.\ C,.\a he-\ LAia(e de- pathcgeen ) de"c^'r.'u.." Jerscv'\e\\eo
[,u6r.61rd.oor Q.ecx Ues ixe\ Seuormd. U-rordl
: lo9 " Soory\ -+ lotsion eor]
Vervb\genS 04e1 (ysoSoo'ran, laSo(ysoSoorvr
t fro\onpomPe.o in he\ fhec,.r\orctan uan cla uesi<e'l fona.pen P.olooen nqcrr
binnen ) wer z''.t-r in9 t o al ioo.cler io S\ ai is ch /l>"cler, c,' d,ac,l <an Zln
o resp,rato,ische bt^,s\: Ueru.Jer<ing Uan
$role hoe.ueelhede-n lol loxisctr^,e
ztr-tr-vs\ofde.ivo"\on d.ie he-i palhogee,-, oxydereo
, 'pothojqe^.r
in me.,. Lcaqn uan de
- ooK foxisdne S\rksloQdecivaron /
. posi\ie-f $e\aden pe,pliden zoa\s de-Ne",$rn€-5 q:orde-., a-o.r.g.-troc[,f v,i:t heJ
\ySoSoon".r e-n Ku"nnen gorien Uorryaerr -) kc.n (a,de", [ol OSoaol, Sche tySe
. in l.lsoso&\er\ f,l[eo drUef se eAzVrv'.es (r'g \9soz'y*eJ d,'q opl,rnaa{ ujerKe.)
%g de Lure Pl-l voc\ he-1 fagolyso5oona
. Cor-rpon e^\e^ in he..t Cogolyrosoo^^ 9aA^ i'A coMpel,lrg &el lc.clo.e n d,q
pathoge^e-v^\ nodg h obben oM le oUer\ e-\/en /verrnentifVt<ld,gen
,@-!e.L.ce uerschi\\end.- o.c\i vo,\ ie.urege^ van 661'np\ er^oo+ ui+
(Al Kr-Rssrxe,rrrvnrre
o,n\i7s\ollen he-.[.\e."' op an{igeneo op hel opperv(a< vaA pa[hogeneo
I del-<- o.nlis\"ffen k(rnAe.o \eideo Io] connp\en^en] aclival ie
) CL cornplsy bindl ao..' L dorqeia uaa anlis!'olleo
i = CL1. = $ Strbt^n;l,s J rqoe.l rhe\ rqinsleos 2- lgG aniis loFCen
' I in\erage(en otu1 ge.qcliv e,erd l-e" worcten n tg /1 rs ook oK) en don
L = c !, ;
,
^ Cl, ', c1v kn rp I a, ac\ ivarie ee^ stule vqn C:*,
) CLs v er<nip\ C\ (aan wez,3 Seru^r e.^ t,'chao.rra5t,[6s{.5l.oCfqi) 1.1 Ceoen C\,
-r 'a.' du.\ toordl lypisch ucagestelcl ierurgt /bt lTp,sch btyt] plor<en
og he+
p a\h o gee^
'c' tyn u o"cK b.tong rgKe ,cy1fni.r no - (egr^taI ore".
'b' ?el[en de cctsca.dc r.roor*
i C1q -;korvr{ los
hech\ aa^ cgu , cls spr;rst c2
'---s'cz
- . uvLlo
\ rro+ bry t+,prakKe^ aG^ cqt
lr = klassiexe C3 converl-ase -) Uerrnipl c3 lol c 3cn en c3t
-) nr,t h.t .1" e-o^ &rb-dal,$ conaptel a Cql"zb3t, ktassiere C3/Csconuer\ose
J uer<n,p\ C3 (eefr'ciJn\er don CqurZ6) .n CS
-) uee-\ C3b xoc,r\ uog eeo hech+ r-.ras{ a6n pathogeen =opson;sal,./
+ CS r= 97: _-> larm\n crte- (on^ p\etne n I act ,'u c,f io
L >b
-,
C\ en C3 loeuo"[\en ee-n in\erne fh,o - esle.r uq.lcinding Cie hoo, b^,len
korn\ ' c,.ls 7e- utOrdeo uer<nipl -) deze- 7l^ hoq (eqctle{ en feagere.o
r,rra\ eiu.-,ilten zA St-.tire-rS q hnf opPerutoK UcLn het pelhoQee-r: t,tiaatdoor
ze o.\s he,l ty'ar e' uasft\uu%
lhlo - €s{e. ve.brnd.rng , RASp-'
[g] t{Bl ..,(\OLEI'ALUT ACTIV/cTII
Suirers\rur-c\wren Oe het oppervta< Uan he-t pcrlhogeen infer nnet
^qe-(e-^
r otn^oSe binclend Lec{ine (l{AL) : een d-cu}e Ca.se e(uri+ d.,e tydens eet
on[s\e<ingsreo.c\ie- t,h v. d.e [eusr geaorrvtd e.o Urgge.[o.Je,n ulorc{.1
o ARL beslqc.\ ps1 Zoals Cal uil 6 sq\<eohedeo
' 2c is g.@cr ,oo.*fgaonde Opsooisa\ie UcL^ hel po.lho yee^ C[-oo. &n+r': folGrr
ne\ z-oct\S ClrL is A{AL Letxens gec{sso cieerc,l rqet 2- kopgerr [/on 2 pr6'l scrsgo
, C1\ -- MBL
, Ca', = HAS?- 1" (Iou a5soc,ctleA se-,i^e*.gco\"ote)
, C1= = |IASP-2
de fesl votgt a"ts Ktassie<
, ALTE RtuATtcVE ao MPLEI'{ENTACr v<l 116
[al I
rneeS\9eUqqrtgxe*"9:heef+ge.e^WSpec,frere,l,ig3er'nod9enKQo
Spon{c.o.n ge-o-c)iuee..c[ c,oordetr.
Cj sg\lIsl SocnS Spontaotn in C3o. ec\ C3b c".r o.o./ tg LAa Zl cA Zctt uas|-
he..h,\ en a.a-.. h e,| r\ee* ct;chls I bgzynde c€[o f pervla< Cpaihogeeo fr\orqr
pote.\\ iee-[ oox tich a.ctrnsaigen cel )-
C ]L uorru^,\ brn d;og:plaqts uoor Cacto. B -? word\ $e<-n,'pl doot Serwftr
pro\ ecrse 6actc'r D ioi Bq en Bt
*i Ro t.=rorc1\ Uer uug dercl , Bb ttgh uas\9el''..[',] cr'o'n CgU = C3 tBt
= he-\ a[terna\iev< C3 conue'r\o'se-
+ ry ha\ o?peru\a< uaft hef polhogee^ 7a.l C,+ corvrplev LJaaK geslab;l;seet,J
(,rrord.en doo.. Fact-or ? (propetd"ine) , op {.,'c\raamseigen ceJ[en t^lord'l
d.i I cor^p\ ex ech he r Sn e( on [cn an I et d
? rnip\ (3 \o{ C3o e^ CiL, *- C36 b${+ p{atteo -1 C3t2f5b
= he-[
e\lero o"tiev<- C\tc5 coouer{ase-
9 ces\ is helze.\ldz a[s de- k[o.ssi ere r-,tle3
[O -l-eR f-l, l'., olg Cottnp.t.mepra c- tv,q-r,e
dl\ [aois\a d.ee,\ uan de- Co.scade \'S (dentr'g6 \JooY A, P" eo C
- C5... en CS b btg',e,o beiden in optossrn3
, CSb 7a\ eersl loinde", Mel C6 eA dagLrna ook C7., Cd ?-n Cg
) na bind;ng C7 (c asb 6l) zo.r het corr,rplex uos lhechleo 51cLo opperutat
uo-ft hei palho q"en
-? dan bind"\ cB ( CS6 6?s) , d.zze zorgl Uoor
= lransrvle-r,,\br^. aire-
uer an ker r'!]
brndin9 uo-q d"ruerse C9', die dool.hon-, he[ et\^b,non
?Y".yotgeos
pane\e ete,. en ee-^ r\
c,'[rn dervar^^ige por re- uarn4en (N- <o nm
) zctrg\ uoc,r osr4olr sch e tgse eo\h"ogn.n Zruett op) a)
+ de- por i e- = }aorvtbrane allact conalrex op /4Ac
u&a< zgo f\eerdere ltAc'r nodig oM ca(dmd he. \tecoo(znkeo
, Eto, .y^ d"e g"rolgen van Corvtplernenlq.livot;e?
o U o r nning HAC s -- oscno\ i sche [Ys e
" oPsonisa\ie (o.cu c:a)
, 'a' d.ee\\Jes t-,tiaaruo.n e( Uer5ch,llend.e, innrnunoregut(er endz lu.nclr'es
hebben
'Lorlz,a uoor .
' n^c(s l ce-l d-egro..Crulal,'es ( his[anain<- koo^{ u.g)
. Uo.hoogdo U&sctr\a,,
e ()a(r eabit, le_, I
. g\odd. e Spiercon\rc^c\iq
. GC\iv al ie pr ctCroCag e-o
' s : op Ue.c5sh,ll.end. z irutMuwn cet[en
Cho$^o \ crxr
' U Qr* y del. eo VaA t'Mfnwwc\ olp-> u I C. b\ o e d b oo. n
a_oo.\ ple-xe-o
urr^ ."1 C-oo-\
\
(uu an\ d,'e- Kunne n Vagt Koyren e.'Ileo en chronr sche on t-s I eKr'n9
usroorzqKen ) -+ Qeopsol-ri seerd /Vlet C3b _> ebC A ob!e., h Ie.
(acep\66 Uoo(
-t \ro.nspor\ pLotar \euer/ort, tl
. in\ . 69\ ie M e+ d iuer se cr.nCe r e @srt-r1.n) cos cade s Zoo.ls
r. :
' b\oed s\o\lrh9
.[;;r,no\y6e
' uorr',r;n g uGn Ktnine 5
