Pharmacology Complete Drug Guide,
Updated 2023, Verified Solution
Acetminophen IV MOA
TYLENOL
(Ofirmev)
Analgesic, antipyretic
Inhibits prostaglandin synthesis and acts on hypothalamus to cause antipyresis
Acetminophen IV Indications/Contraindications
TYLENOL
(Ofirmev)
Indications:
-mild to moderate pain
-severe pain when other analgesics are contraindicated
-fever (hospitals)
-adjunct with opioid analgesics for pain (hospital)
Acetminophen IV Dosages
TYLENOL
(Ofirmev)
1 gm IV/IO infusion (IVPB) over 15 mins.
Single dose only
Acetminophen IV Side Effects
TYLENOL
(Ofirmev)
-allergic rxn/anaphylaxis
-muscle pain, cramps, twitching
-lockjaw
-sweating
-numbness/tingling in hands, feet, lips
-dizziness or lightheadedness when moving from supine to standing
-nausea/vom
-irregular heartbeat
lower back, side, stomach pain
-MAY CAUSE LIVER IMPAIRMENT IF GIVEN IN LARGE DOSE OR TOO QUICKLY
Activated Charcoal MOA
(Acta-Char)
Charcoal treated with O2
directly adsorbs (binds) with molecules of a multitude of substances (toxins in EMS)
Activated Charcoal Indications/Contraindications
(Acta-Char)
Indications:
-oral toxic ingestion w/in 1 hr of EMS contact
,Contraindications:
-ALOC or unprotected airway
-to prevent aspiration, should not be given for substances that are known not to be
absorbed
-Corrosive ingestions (obscures endoscopy) unless there are life-threatening co-
ingestants
Activated Charcoal Dosage
(Acta-Char)
1g/kg PO/NG
REMSA 50g
Activated Charcoal Precautions
(Acta-Char)
-increases risk of aspiration
-shake prior to use
Adenosine MOA
(Adenocard)
Antiarrhythmic
Natural nucleoside found in body. Stimulates reduces electrical conduction in SA and
AV node.
Decreases SA node automaticity, conduction velocity, and increases AV refractoriness
Adenosine Indications/Contraindications
(Adenocard)
Indications:
-Narrow complex tachycardia (SVT/PSVT)
-SVT with aberrancy (looks like VTAC)
Contraindications:
-2nd and 3rd degree heart block
-Hx of sick sinus syndrome
Adenosine Dosage
(Adenocard)
6 mg rapid IVP/IO followed by 10-20 mL flush
may repeat with 12mg + flush twice after 1-2 mins. each
Adenosine Side Effects
(Adenocard)
-headache
-chest pain
-flushing
-dyspnea/bronchoconstriction
-bradycardia
, -AV block
-sinus pause/asystole/PVCs
Adenosine Precautions
(Adenocard)
-admin to patients with AFib or WPW may cause VFib
-may induce airway hyperrresponsiveness and should be used with caution in asthma
hx
-patients status post heart transplant may have increased sensitivity
-cannulate largest vein possible to facilitate rapid flush
Albuterol MOA
(ventolin, proventil)
sympathomimetic bronchodilator, beta-2 adrenic agonist
Stimulates beta-2 receptors, causing relaxation of bronchial smooth muscle, and
relaxation of vascular and uterine smooth muscle
Albuterol Indications/Contraindications
Indications:
1. Bronchospasms assoc. with:
-asthma/reactive airway
-toxic gas inhalation/OD
-allergic rxn/anaphylaxis
-COPD
-drowning
2. hyperkalemia (crush injury)
Contraindications:
-known hypersensitivity
Albuterol Dosage
2.5 mg in 3 mL NS nebulized
repeat as needed
Albuterol Side Effects
-tachycardia
-palpitations/ectopy
-tremors
-headache
-nau/vom
-coughing
Albuterol Precautions
-use caution with patients with myocardial ischemia
-paradoxical bronchospasm may occur
-BETA BLOCKERS AND ALBUTEROL INHIBIT EACH OTHER
Amiodarone MOA
(Cordarone)
Class III antiarrhythmic
Updated 2023, Verified Solution
Acetminophen IV MOA
TYLENOL
(Ofirmev)
Analgesic, antipyretic
Inhibits prostaglandin synthesis and acts on hypothalamus to cause antipyresis
Acetminophen IV Indications/Contraindications
TYLENOL
(Ofirmev)
Indications:
-mild to moderate pain
-severe pain when other analgesics are contraindicated
-fever (hospitals)
-adjunct with opioid analgesics for pain (hospital)
Acetminophen IV Dosages
TYLENOL
(Ofirmev)
1 gm IV/IO infusion (IVPB) over 15 mins.
Single dose only
Acetminophen IV Side Effects
TYLENOL
(Ofirmev)
-allergic rxn/anaphylaxis
-muscle pain, cramps, twitching
-lockjaw
-sweating
-numbness/tingling in hands, feet, lips
-dizziness or lightheadedness when moving from supine to standing
-nausea/vom
-irregular heartbeat
lower back, side, stomach pain
-MAY CAUSE LIVER IMPAIRMENT IF GIVEN IN LARGE DOSE OR TOO QUICKLY
Activated Charcoal MOA
(Acta-Char)
Charcoal treated with O2
directly adsorbs (binds) with molecules of a multitude of substances (toxins in EMS)
Activated Charcoal Indications/Contraindications
(Acta-Char)
Indications:
-oral toxic ingestion w/in 1 hr of EMS contact
,Contraindications:
-ALOC or unprotected airway
-to prevent aspiration, should not be given for substances that are known not to be
absorbed
-Corrosive ingestions (obscures endoscopy) unless there are life-threatening co-
ingestants
Activated Charcoal Dosage
(Acta-Char)
1g/kg PO/NG
REMSA 50g
Activated Charcoal Precautions
(Acta-Char)
-increases risk of aspiration
-shake prior to use
Adenosine MOA
(Adenocard)
Antiarrhythmic
Natural nucleoside found in body. Stimulates reduces electrical conduction in SA and
AV node.
Decreases SA node automaticity, conduction velocity, and increases AV refractoriness
Adenosine Indications/Contraindications
(Adenocard)
Indications:
-Narrow complex tachycardia (SVT/PSVT)
-SVT with aberrancy (looks like VTAC)
Contraindications:
-2nd and 3rd degree heart block
-Hx of sick sinus syndrome
Adenosine Dosage
(Adenocard)
6 mg rapid IVP/IO followed by 10-20 mL flush
may repeat with 12mg + flush twice after 1-2 mins. each
Adenosine Side Effects
(Adenocard)
-headache
-chest pain
-flushing
-dyspnea/bronchoconstriction
-bradycardia
, -AV block
-sinus pause/asystole/PVCs
Adenosine Precautions
(Adenocard)
-admin to patients with AFib or WPW may cause VFib
-may induce airway hyperrresponsiveness and should be used with caution in asthma
hx
-patients status post heart transplant may have increased sensitivity
-cannulate largest vein possible to facilitate rapid flush
Albuterol MOA
(ventolin, proventil)
sympathomimetic bronchodilator, beta-2 adrenic agonist
Stimulates beta-2 receptors, causing relaxation of bronchial smooth muscle, and
relaxation of vascular and uterine smooth muscle
Albuterol Indications/Contraindications
Indications:
1. Bronchospasms assoc. with:
-asthma/reactive airway
-toxic gas inhalation/OD
-allergic rxn/anaphylaxis
-COPD
-drowning
2. hyperkalemia (crush injury)
Contraindications:
-known hypersensitivity
Albuterol Dosage
2.5 mg in 3 mL NS nebulized
repeat as needed
Albuterol Side Effects
-tachycardia
-palpitations/ectopy
-tremors
-headache
-nau/vom
-coughing
Albuterol Precautions
-use caution with patients with myocardial ischemia
-paradoxical bronchospasm may occur
-BETA BLOCKERS AND ALBUTEROL INHIBIT EACH OTHER
Amiodarone MOA
(Cordarone)
Class III antiarrhythmic
