NR 546 Test Your Knowledge Quiz Week 2 with Answers- Chamberlain College of Nursing

NR 546 Test Your Knowledge Quiz Week 2 with Answers- Chamberlain College of Nursing Week 2 Review 1. Human central nervous system communication at synapses is which of the following? Chemical The communication between neurons at synapses is mediated by neurotransmitter molecules and is therefore chemical. 2. Which of the following is a prominent CYP enzyme in the body and what is it responsible for? CYP3A4 - responsible for metabolism of a number of medications CYP 3A4 is one of the 5 most important NT which include CYP 1A2, 2D6, 2C9, 2C19, 3A4. Dosing adjustments may be required. 3. Which of the following are involved in regulating neurotransmission via excitation secretion coupling? voltage-sensitive sodium channels and voltage-sensitive calcium channels 4. Which is a first messenger? Neurotransmitter G protein linked systems and ion channel linked cascades are triggered by neurotransmitters. 5. Which of the following is an excitatory neurotransmitter? Glutamate Glutamate is an excitatory neurotransmitter. (NEI glutamate video- the glutamate sisters) 6. Nicotine is an inducer of the CYP 1A2 enzyme. 7. Title: Phase 1 Metabolism Drug is ingested • Orally Phase 1 metabolism (chemical reaction) • Oxidation (most common) • Reduction • Hydrolysis 3 possible outcomes • Drug becomes completely inactive • Drug becomes partially inactive but one or more metabolites remain active • Original drug is not pharmacologically active but one metabolite remains active Inhibitors decrease medication metabolism • Valproate • Isoniazid • Sulfonamides • Amiodarone • Choramphenicol • Ketoconazole • Grapefruit Juice • Quinidine • Remember: VISA credit card debt inhibits spending on designers like CK to look GQ. Remember the inducers: • Carbamazepine • Rifampin • Alcohol • Phenytoin • Griseofulvin • Phenobarbital • Sulfonylureas • *Increase medication metabolism GABA-Hi there! I am the amino acid GABA: my formal name is gamma-aminobutyric acid. Just call me GABA. I am the chief inhibitory neurotransmitter (NT). The opposite of Glu. I decrease neuroexcitability across the brain. I bring the “chill” to the party. I say party because people really like me when I take the edge off stress and help them calm down. I help people relax, destress, and get some sleep. When people don’t have enough of me, they may experience anxiety or even schizophrenia. Some meds use my benefits to help people sleep for medical procedures. When prescribed appropriately I can be of great benefit to your clients. You can see my effects when people drink alcohol. A few drinks and people are super social and up for just about anything. I’m told these are great benefits, but some people abuse alcohol and medications that target me, such as benzodiazepines. I don’t just calm down those emotions, I slow down everything, even breathing, which can be dangerous. I also affect the executive function and motor coordination, making people more at risk for accidents. NE-Hello, I am norepinephrine, NE for short. I am also a monoamine neurotransmitter and I serve many functions in the human body. Do you remember learning about flight, fight, or fright? That’s me, in excess. A little NE can get you up off the couch and have you alert, oriented, and ready to take on life’s challenges. I can really help with focus and produc