NURS 660 EXAM 3 2023 With verified solutions

1. What is the medication that is the antidote for alprazolam?: flumazenil 2. What is the MOA of pregabalin that makes it alleviate pain for people with fibromyalgia or chronic fatigue?: binds to the alpha 2 delta sub-units of voltage sensitive calcium channels 3. What is an antagonist of caffeine: adenosine 4. Diagnose this pt: Patient comes in with a CC of anxiety. She has been excessively worrying, increased arousal, increased tiredness and irritability. What is the primary and least likely diagnosis?: GAD; Panic Disorder 5. Somebody w/ anxiety worries about having a panic attack, in addition has mood changes to avoid things in order to not have a panic attack.: Panic disorder 6. A woman was raped, and continues to have fear of opposite sex on her way to parking garage. Which two areas of the brain are involved?: amygdala and hippocampus 7. MOA of modafinil (Provigil). How does it promote normal wakefulness: his- tamine, NE at alpha adrenergic receptor sites, dopamine at D2 receptors 8. What is the MOA of eszopiclone? What receptors does it act on?: Binds to GABA receptors to increase GABA to increase sleepiness 9. Which would be the first line appropriate pharmacological agent for PTSD?: Paroxetine 10. What mediation is used to alleviate to help cognitive pain and physical symptoms in fibromyalgia?: Milnacepran (Savella) 11. With the difficulty breathing is related hypothetically to the activation of what area of the brain?: parabrachial nucleous 12. What medications are good for falling asleep "sleep induction" and are not addictive?: Suvorexant (Belsmora) 13. Know the MOA of buspirone. Which receptor does it primarily act upon?- : serotonin 1a 5HT1A partial agonist 14. How does melatonin improve sleep? What receptors does it act on? Agonist or antatonist?: Secreted by the pineal glad to attach to receptors in the suprachiasmic nucleus to regulate the circadian rhythm; agonist 15. Current dx of generalized anxiety disorder (GAD), difficulty concentrating as well as problems falling asleep. She gets very angry over basic things and is very moody in general, excessive stressful reactions, concentrate, irritability. What is going on in her brain?: a. Dysfunction of amygdale and CTSC (serotonin/nor-einephrine) 16. Pt is coming in for detox with a long hx of alcohol abuse, HTN, and cirrhosis. He reports 12 beers daily for weeks. Has w/d seizures when he tries to stop drinking on his own. So he has elevated AST, LFT....what agent would you choose to detox him?: lorazepam 17. Someone comes in with chronic hepatitis, also has chronic neuropathic pain. What medication would you AVOID prescribing to this patient and why?: Cymbalta; elevates LFTs