B1002B - Practice Questions for February Test 2021
1. A useful bioinformatics tool is one that can determine the number of open-reading frames
(ORFs) in a genome.
Why is knowing the number of ORFs useful?
A. It gives an estimate of the number of promoter sequences in a genome.
B. It gives an estimate of the number of genes in a genome.
C. It gives an estimate of the number of proteins coded by a genome.
D. It gives an estimate of the number of bases in a genome.
2. Cilia are important features of many human cells and are classified as either motile or non-
motile cilia.
Which of the following statements accurately describes ciliated cells?
1. Like cells with flagella, ciliated cells lack mitochondria.
2. Most cilia-based human diseases are caused by defects in non-motile cilia.
3. Like humans, Chlamydomonas has both motile and non-motile flagella.
4. Cells with non-motile cilia usually have sensory membrane proteins.
A. 1, 2 and 3
B. 1 and 3
C. 2 and 4
D. 4 only
E. All of 1, 2, 3 and 4 are correct
3. Recall from Class 1 that we discussed the analysis of 7,476 Chlamydomonas proteins and
compared them to proteins in humans and Arabidopsis.
What is an example of a protein that is found in all three species: Chlamydomonas,
humans and Arabidopsis?
A. Opsin, a seven transmembrane domain protein that binds retinal.
B. Toc1, a protein of the outer mitochondrial membrane.
C. Hexolyase4, an enzyme involved in chlorophyll biosynthesis.
D. Dynein, a cytoskeletal protein involved in cilia and flagella assembly.
4. In the field of optogenetics, Chlamydomonas opsin is expressed in mouse neurons.
Why can’t optogenetic experiments just use mouse opsin?
A. Because mouse opsin doesn’t bind retinal.
B. Because mouse opsin doesn’t trigger an action potential.
C. Because mouse opsin is not sensitive to
light.
D. Because mouse opsin is not an ion channel.
1. A useful bioinformatics tool is one that can determine the number of open-reading frames
(ORFs) in a genome.
Why is knowing the number of ORFs useful?
A. It gives an estimate of the number of promoter sequences in a genome.
B. It gives an estimate of the number of genes in a genome.
C. It gives an estimate of the number of proteins coded by a genome.
D. It gives an estimate of the number of bases in a genome.
2. Cilia are important features of many human cells and are classified as either motile or non-
motile cilia.
Which of the following statements accurately describes ciliated cells?
1. Like cells with flagella, ciliated cells lack mitochondria.
2. Most cilia-based human diseases are caused by defects in non-motile cilia.
3. Like humans, Chlamydomonas has both motile and non-motile flagella.
4. Cells with non-motile cilia usually have sensory membrane proteins.
A. 1, 2 and 3
B. 1 and 3
C. 2 and 4
D. 4 only
E. All of 1, 2, 3 and 4 are correct
3. Recall from Class 1 that we discussed the analysis of 7,476 Chlamydomonas proteins and
compared them to proteins in humans and Arabidopsis.
What is an example of a protein that is found in all three species: Chlamydomonas,
humans and Arabidopsis?
A. Opsin, a seven transmembrane domain protein that binds retinal.
B. Toc1, a protein of the outer mitochondrial membrane.
C. Hexolyase4, an enzyme involved in chlorophyll biosynthesis.
D. Dynein, a cytoskeletal protein involved in cilia and flagella assembly.
4. In the field of optogenetics, Chlamydomonas opsin is expressed in mouse neurons.
Why can’t optogenetic experiments just use mouse opsin?
A. Because mouse opsin doesn’t bind retinal.
B. Because mouse opsin doesn’t trigger an action potential.
C. Because mouse opsin is not sensitive to
light.
D. Because mouse opsin is not an ion channel.
