PATHOPHYSIOLOGY
What is the effect of oxidized low density lipoproteins (LDLs) in atherosclerosis
- LDLs cause smooth muscle proliferation
Which inflammatory cytokines are released when endothelial cells are injured
- Tumor necrosis factor-alpha (TNF-a), interferon-gamma (IFN-y), and interleukin 1
(IL-1)
When endothelia cells are injured, which alteration contributes to atherosclerosis
- Cells are unable to make the normal amount of vasodilating cytokines
Which factor is responsible for hypertrophy of the myocardium associated with
hypertension
- Angiotensin II
Which effect does atherosclerosis have on the development of an aneurysm
- Atherosclerosis erodes the vessel walls
Regarding the endothelium, what is the difference between healthy vessel walls and
those that promote clot formation
- Inflammation and roughening of the endothelium of the artery are present
Which form of angina occurs most often during sleep as a result of vasospasms of
one or more coronary arteries
- Prinzmetal
The pulsus paradoxus that occurs as a result of pericardial effusion is caused by a
dysfunction in which mechanism
- Diastolic filling pressure of the left ventricle and reduction of blood volume in all
four heart chambers
Ventricular dilation and grossly impaired systolic function, leading to dilated heart
failure, characterize which form of cardiomyopathy