Module 3 -
Stereochemistry,
Organic reactions and
synthesis of a drug
molecule
Contents
Structural isomers and stereoisomers, configurations and
symmetry and chirality, enantiomers, diastereomers,
optical activity, absolute configurations, conformational
analysis of alkanes and cycloalkanes.
Introduction to reactions involving substitution, addition,
elimination, oxidation, reduction, cyclization and ring
openings. Synthesis of a commonly used drug molecule
(Aspirin, paracetamol, phenacetin).
All organic compounds consist of carbon and
hydrogen.
Many also contain oxygen and nitrogen
Other elements may also be present, Phosphorous,
halogens and/or metals
Most compounds are composed of carbon chains
bonded with hydrogen
H-
–H
H
H
H
H
H
|
,|
|
|
|
C–C–C–C–C
|
|
|
|
|
H
H
H
H
H
A carbon / hydrogen chain (organic) -
Hydrocarbon
H-
–O-H
H
H
H
, H
H
|
|
|
|
|
C–C–C
–C–
C
|
|
|
|
|
H
H
H
H
H
A carbon / hydrogen chain containing oxygen
– Derivative of hydrocarbon
Carbon
Hydrogen
Stereochemistry,
Organic reactions and
synthesis of a drug
molecule
Contents
Structural isomers and stereoisomers, configurations and
symmetry and chirality, enantiomers, diastereomers,
optical activity, absolute configurations, conformational
analysis of alkanes and cycloalkanes.
Introduction to reactions involving substitution, addition,
elimination, oxidation, reduction, cyclization and ring
openings. Synthesis of a commonly used drug molecule
(Aspirin, paracetamol, phenacetin).
All organic compounds consist of carbon and
hydrogen.
Many also contain oxygen and nitrogen
Other elements may also be present, Phosphorous,
halogens and/or metals
Most compounds are composed of carbon chains
bonded with hydrogen
H-
–H
H
H
H
H
H
|
,|
|
|
|
C–C–C–C–C
|
|
|
|
|
H
H
H
H
H
A carbon / hydrogen chain (organic) -
Hydrocarbon
H-
–O-H
H
H
H
, H
H
|
|
|
|
|
C–C–C
–C–
C
|
|
|
|
|
H
H
H
H
H
A carbon / hydrogen chain containing oxygen
– Derivative of hydrocarbon
Carbon
Hydrogen
