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Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD)

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Several lines of evidence suggest that the intra- and inter-cellular messenger nitric oxide (NO) is critically involved in anxiety. Contrasting findings are reported, however, regarding the effects of NO donors in preclinical models of anxiety. Previous research has shown that challenge with a low dose range of the NO donors sodium nitroprusside (SNP) and molsidomine induce anti-anxiety-like effects in rodents. There is poor information concerning the effects of these NO donors on preclinical models mimicking the obsessive-compulsive disorder (OCD) and the post-traumatic stress disorder (PTSD). The present research was designed to investigate this issue in the rat. To this end, the mCPP-induced excessive self-grooming and the contextual fear conditioning (CFC) test which are behavioural paradigms resembling OCD and PTSD respectively in rodents were used. Acute administration of SNP (1 mg/kg) and molsidomine (4 mg/kg) attenuated excessive self-grooming induced by the 5-HT2C receptor agonist mCPP (0.6 mg/kg). Further, at the same dosage, both these NO donors reduced freezing behaviour evidenced in the CFC test. The present results suggest that NO donors are efficacious in attenuating abnormal behaviours revealed in animal models of OCD and PTSD which are among the most severe pathologies of anxiety.

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November 27, 2022
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, What are Obsessive-Compulsive Spectrum Disorders




• A group of similar psychiatric disorders.
• Characterized by repetitive thoughts, distressing emotions, and compulsive behaviors.
• The specific types of thoughts, emotions, and behaviors vary according to each disorder.
• These disorders are:
1) obsessive-compulsive disorder (OCD);
2) body dysmorphic disorder (BDD);
3) hoarding disorder;
4) hair-pulling disorder (trichotillomania);
5) skin-picking disorder (excoriation).
6) substance/medication-induced obsessive-compulsive related disorder;
7) obsessive-compulsive and related disorder due to another medical condition;
8) other specified obsessive and compulsive and related disorders; and,
9) unspecified obsessive-compulsive and related disorders (such as body-focused repetitive
behavior disorder and obsessional jealousy).

, Obsessions
recurrent and persistent thoughts, urges, or images that are experienced as intrusive and
unwanted.
Common obsessional themes;
 concerns about contamination;
 harm happening to oneself or others;
 intrusive sexual thoughts;
 religious preoccupation and rituals;
 repeated and excessive doubts about safety and security;
 the need for symmetry and order;
 perfectionism.
Because obsessions are unwanted, they create anxiety and distress when they occur. To
reduce this discomfort people perform compulsions.

Compulsions
Behaviors or mental acts that a person feels "driven" to perform in response to an obsession.
Common compulsions;
 excessive hand washing;
 re-ordering objects in a specific way;
 checking on safety and security (a door lock, an electric appliance);
 counting (aloud or silently);
 the ritualistic repetition of prayers in one's mind.
Obsessive-compulsive spectrum disorders share many similar features. However, there are also
important differences. The following example illustrates the importance of these differences.
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