Maryville NURS 663 EXAM 1/ Study
Guide With Complete Solutions.
SIADH - Answer Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
is a condition in which the body makes too much antidiuretic hormone (ADH). This
hormone helps the kidneys control the amount of water your body loses through the
urine. SIADH causes the body to retain too much water
Causes of SIADH - Answer
Carbamazepine (Tegretol)
Is primarily metabolized by ______ (cytochrome P450) - Answer Is primarily
metabolized by cytochrome P450 3A4
HORRIBLE D/T DRUG-DRUG INTERACTIONS
ANTICONVULSANT
•First line agent for acute mania and mania prophylaxis
•Indicated for rapid cyclers and mixed patients
Carbamazepine (Tegretol)
LABS and DOSAGE - Answer •Before med is started: baseline LIVER function tests,
CBC, THYROID, KIDNEY, PREGNANCY and an EKG
•Monitoring: Steady state achieved after 5 days -check 12 hours after last dose and
repeat CBC and LFT
•Goal: Target levels 4-12mcg/ml
400-1200 mg/day
•Need to check level and adjust dosing after around a month because induces own
metabolism.
Escitalopram (Lexapro) - Answer SSRI (NEUTRAL), MDD, GAD
•Pros
-Low overall inhibition of P450s enzymes so fewer drug-drug interactions
-Intermediate 1/2 life
-More effective than Citalopram in acute response and remission
•Cons
-Dose-dependent QT interval prolongation with doses of 10-30mg daily
Nausea, headache
Fluoxetine (Prozac) - Answer SSRI (ACTIVATING) LONG HALF LIFE
MDD, OCD, PMDD, BULIMIA, PANIC DISORDER
OK FOR KIDS
Paroxetine (Paxil) - Answer SSRI (SEDATING/WT GAIN)
Guide With Complete Solutions.
SIADH - Answer Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
is a condition in which the body makes too much antidiuretic hormone (ADH). This
hormone helps the kidneys control the amount of water your body loses through the
urine. SIADH causes the body to retain too much water
Causes of SIADH - Answer
Carbamazepine (Tegretol)
Is primarily metabolized by ______ (cytochrome P450) - Answer Is primarily
metabolized by cytochrome P450 3A4
HORRIBLE D/T DRUG-DRUG INTERACTIONS
ANTICONVULSANT
•First line agent for acute mania and mania prophylaxis
•Indicated for rapid cyclers and mixed patients
Carbamazepine (Tegretol)
LABS and DOSAGE - Answer •Before med is started: baseline LIVER function tests,
CBC, THYROID, KIDNEY, PREGNANCY and an EKG
•Monitoring: Steady state achieved after 5 days -check 12 hours after last dose and
repeat CBC and LFT
•Goal: Target levels 4-12mcg/ml
400-1200 mg/day
•Need to check level and adjust dosing after around a month because induces own
metabolism.
Escitalopram (Lexapro) - Answer SSRI (NEUTRAL), MDD, GAD
•Pros
-Low overall inhibition of P450s enzymes so fewer drug-drug interactions
-Intermediate 1/2 life
-More effective than Citalopram in acute response and remission
•Cons
-Dose-dependent QT interval prolongation with doses of 10-30mg daily
Nausea, headache
Fluoxetine (Prozac) - Answer SSRI (ACTIVATING) LONG HALF LIFE
MDD, OCD, PMDD, BULIMIA, PANIC DISORDER
OK FOR KIDS
Paroxetine (Paxil) - Answer SSRI (SEDATING/WT GAIN)
