BIOCHEM C785 UNIT 2 QUIZ 2022/2023

BIOCHEM C785 UNIT 2 QUIZ 2022/2023 Biochemistry – C785 Unit 2 Quiz 1. Which level of protein structure is disrupted through the hydrolysis of peptide bonds? a. Primary 2. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid glutamate in position 6 with the amino acid valine, leads to the development of sickle cell anemia. The structures of glutamate and valine are shown below. If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the valine in position 6 was replaced with a different amino acid, which replacement for valine would be expected to have the best clinical outcome, in theory, for the patient? (Assume the valine can potentially be replaced with any amino acid other than glutamate.) a. (amino acid structure 4) 3. Secondary, tertiary, and quaternary levels of protein structure can all be impacted by exposing a protein to which treatment? a. Placement of the protein in a solution with low pH. 4. An increase in beta-pleated sheet structure in some brain proteins can lead to an increase in amyloid deposit formation, characteristic of some neurodegenerative diseases. What is the primary biochemical process that follows the increase in beta-pleated sheet structure that leads to the development of the amyloid deposits? a. Aggregation of the proteins in the brain 5. Which level of protein structure is determined by the sequence of amino acids? a. Primary structure 6. Which force is most influential in determining the secondary structure of a protein? a. Hydrogen bonding 7. Which amino acid would most likely participate in hydrogen bonds?