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Samenvatting Antibioticaresistentie en gevoeligheidspatronen praktijk blok 1 minor Medische Microbiologie

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In deze samenvatting komt heel uitgebreid de antibiotica resistentie en de gevoeligheidspatronen van de bacteriën aan bod. Deze samenvatting is gebaseerd op blok 1 van praktijk van de minor Medische Microbiologie. Er komt uitgebreid aan bod welke antibiotica resistenties er zijn en welke gevoeligheidspatronen bacteriën kunnen hebben. Het is een Nederlandstalig document en de informatie die in dit document staat is vanuit het eerste blok van praktijk en kan getoetst worden tijdens het praktische tentamen.

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Antibioticaresistentie en gevoeligheidspatronen




Made by: Iris Gülcher

,Inhoudsopgave
Antibiotica resistentie en gevoeligheidspatronen Bijzonder resistente micro-organismen (BRMO) ..... 3
Hoofdgroepen β-lactam antibiotica .................................................................................................... 3
Gramnegatievie staven met resistentie = BRMO (bijzonder resistent micro organisme) .................. 4
Resistentie mechanisme ESBL (Extended Spectrum Beta-Lactamase) ........................................... 4
Resistentie mechanisme CPE (Carbapenemase-producerende Enterobacteriaceae) (vaak
pseudomonas) ................................................................................................................................. 5
Fluorochinolonen- en aminoglycosiden-resistentie (dubbelresistentie) ........................................ 5
AMP-C .............................................................................................................................................. 6
Effluxpomp ...................................................................................................................................... 6
Grampositieve staven.......................................................................................................................... 6
MRSA Meticilline-resistente Staphylococcus aureus ...................................................................... 6
ERM-gen .......................................................................................................................................... 6
PENG1 .............................................................................................................................................. 6
Enterococcen ....................................................................................................................................... 7
VRE (ancomycine Resistente Enterokok) ........................................................................................ 7
Antibiotica groepen ............................................................................................................................. 7
Overzicht antibiotica ............................................................................................................................... 8




Made by: Iris Gülcher

, Antibiotica resistentie en gevoeligheidspatronen Bijzonder resistente
micro-organismen (BRMO)

Stam Plaat en stoof Sensitive Intermidiate Resistent Patroon
Klebsiella Muller Hinton O2 CXM30 AMP30 - Geen verdenkingen voor
pneumoniae CAZ30 AMP10 BRMO
SxT25
MRP10
Enterobacter Muller Hinton O2 CXM30 SXT25 AMPC30 Verdenking voor ESBL
aerogenes MRP10 CAZ30 AMP10

Staphylococcus Muller Hinton O2 GEN30 VANC5 PENG1 Verdacht voor beta
aureus ERY15 CLI2 lacatamase, hebben
CFO30 meestal geen speciaal
mechanisme
Staphylococcus Muller Hinton O2 CFO30 VANC5 PENG1 Verdacht voor beta
saprophyticus ERY15 lactamase
CLI.2
GEN30
Pseudomonas Muller Hinton O2 GEN30 SXT25 - Geen verdenking voor
aeruginosa CIPR5 BRMO
CAZ30S
MRP10
PI+TZ
Multi resistente Muller Hinton O2 PI+TZ GEN30 CAZ30 Verdacht voor ESBL
Enterobacter MRP10 SXT25
CIPR5
CAZ30
Haemophilus Muller Hinton F AMP2 CLA15 - Geen verdenking BRMO
influenzae CO2 CXM30 SXT25
CIPR5
TET30
Moraxella Muller Hinton F CXM30 AMP2 - Cefinase test (positief):
catarrhalis CO2 SXT25 Resistent voor penicillines
CIPR5 en amoxcillines
TET30
CLA15


Hoofdgroepen β-lactam antibiotica
Penicillines (gewone penicillines werken niet bij gramnegatieve staven)
Ceflosporines (cefalosporines 1e t/m 4e generatie
Carbapenems
Monobactam




Made by: Iris Gülcher

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