Robbins Pathology Summary - Tuberculosis

TUBERCULOSIS
Tuberculosis is a chronic
granulomatous disorder caused
Etiology
by:

Mycobacterium Tuberculosis M. tuberculosis M. bovis
Mycobacterium Bovis

Transmitted by: Spread through
unpasteurized
Mycobacterium milk
Tuberculosis Aerosol transmission
from infected
It is an acid-fast bacilli humans

Acid-fastness is due to Risk Factors
presence of mycolic acids

Weakly gram-positive For Infection For
Transmission
Mycosides
Immunocompromised
Mycolic acid state
Young females
Arabinogalactan Old males
LAM
Sputum +ve patient
Plasma Membrane Overcrowding
Miliary TB

, Pathogenesis: Inhibition of phagosome-
lysosome fusion
CMI plays an important role
in the pathogenesis of
tuberculosis
Bacilli
Before Activation of CMI proliferates
inside
Bacilli enter lungs via the macrophage
aerosol route

LAM of bacilli bind to Rupture of macrophages
Mannose-binding receptor
of alveolar macropahges Bacteremia

Seeding to multiple sides




This process occurs for
3 weeks after entry

Patient is asymptomatic
at this stage




LAM activate Coronins

Activate phosphatase-
calcineurin