Reading DNA

READING DNA GENES
C ene expression varies between cells

Every cell has the same DNA
In any one cell not all the
genes are used

to direct production of the encoded protein
Different cell types express distinctive
sets of genes


Gene expressionchanges in disease
Cells respond to
stimuli with changes in gene
expression
Pancreatic ductal adenocarcinoma
PDA Pancreatic stellate cells
Quiescent to activated form
Vitamin D receptor CVDR acts as
a master transcriptional regulator
of PS C s to reprise the qui scent state
VDR
ligand reduces fibrosis and inflammation and
enhances the
efficacy of a co administered Chemotoxic
agent

Regulation of gene expression

, Multilevel control of
gene expression




Regulation of transcription
DNA packaged around
his tone proteins chromatin
Histone modification
acetylation regulates
access to the DNA
Histone acetylation T
transcription
Modification of histories as cancer Histone
therapy
deacetylaseS or H DACS
Regulatory proteins bind
to specific sequences in DNA
Promote transcription of
the adjacent
gene
Various TFS
drugs target