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Summary Augmentin (Co-Amoxiclav) Drug Fact Sheet

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2020/2021 Written for academic year
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Bournemouth University
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Medicines Management
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This fact sheet will explain all you need to know regarding the safe administration of Augmentin (Co-amoxiclav) including dosage, pharmacodynamics, side effects, interactions, contraindications and administration. Perfect for student midwives!

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Augmentin (Co-amoxiclav)

BASICS: DOSAGE:
• Antibiotic - broad spectrum penicillinase • 375mg or 625mg (if severe infection) t.d.s.
against amoxicillin resistant organisms tablets orally

• UTIs, prophylaxis • 600mg-1.2g if IV infusion

• POM

• Tablets, suspension, powder for
reconstitution




SIDE EFFECTS: PHARMACODYNAMICS:
• Nausea • Semi-synthetic penicillin that inhibits
• Diarrhoea enzymes that are involved in cell wall
synthesis
• Rashes
• Augmentin contains amoxicillin and
• Rarely - hepatic impairments
clavulanic acid that inactivates beta
CONTRAINDICATIONS: lactamase enzymes which stops the
amoxicillin being affected and therefore it
• Penicillin hypersensitivity
can kill the resistant bacteria
• Hepatic dysfunction :
• Eliminated via the kidneys




INTERACTIONS: FETAL/BREASTFEEDING RISK:
• Anticoagulants • Benefits must outweigh the risks if using
it - from manufacturer
• Methotrexate
• Not for use in 1st trimester

• Crosses into breastmilk - can cause
GUIDELINES:
diarrhoea and constipation as it can affect
• BNF - avoid in PPROM as possible the gut flora
increased risk of necrotising enterocolitis
in newborns

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Bournemouth University
Uploaded on
January 23, 2022
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Written in
2020/2021
Type
Summary
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Browse related subjects

Subjects

  • augmentin
  • co amoxiclav
  • antibiotics
  • labour care
  • midwifery
  • midwife
  • postnatal
  • birth

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