Alexandra Nedelcu Unit 4C
Aspirin synthesis
What is aspirin?
Aspirin belongs to the class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs)
(NSAIDs). It's used as a treatment for mild to moderate pain and inflammation.
Your body produces prostaglandins after you've been wounded or have an infection. Prostaglandins
produce swelling and, in some cases, fever, as well as transmitting pain signals to the brain. This is all
a natural aspect of your body's response to an injury. The swelling and fever may aid in the healing
process.
Aspirin inhibits the production of prostaglandins, which reduces pain, swelling, and fever. [Juliet,B,
(2018)]
Risk Assessment
To prevent chemical splashes and spillages, all personnel and students must wear lab coats that are
knee-length, long-sleeved, clean, and unmarked during the experiment. Tucking loose clothing inside
the lab coat or tucking it away is required, as well as wearing suitable apparel to defend against the
chemicals.
Smoking, drinking and eating is not permitted because the food could become contaminated with
the chemicals in the lab and poison you, smoking, drinking, and eating are not authorised. The lab
may have highly sensitive equipment that may be ruined if you spilled food or drink on it. The food
may contaminate the specimens being tested, which will give inaccurate results.
When latex or nitrile gloves are appropriate or required, they must be worn. Chemical resistance and
protection are greater with these gloves. It is beneficial to dispose of gloves as frequently as possible
in order to reduce contamination and maintain protection.Utilise one gloved hand to use or carry
chemicals between laboratories, and keep the other hand ungloved to open and close doors to
further prevent contamination.
During the experiment, acetic anhydride is utilised, which is a flammable material that poses a safety
risk. The following procedures are taken to minimise the dangers connected with this substance:
Keep ignition sources (sparks, smoke, flames, and hot surfaces) to a minimum when working with
flammable and combustible liquids. During the experiment, use as little flammable liquid as feasible.
Keep goods cool and dry in storage rooms. Distinguish flammable and combustible liquids from
incompatible materials (e.g., oxidizers).
Another substance is sulphuric acid, which is a corrosive chemical that can harm a person's health by
burning and destroying body tissues when it comes into touch with them. The stronger or more
concentrated the corrosive substance is, and the longer it is in contact with the body, the more
severe the injuries. Corrosive liquids should never be stored above eye level to reduce the risk of
these substances. Acids and bases should always be mixed with water (and not the reverse). Acids
and bases should be kept separate, and when mixing corrosive substances with water, add the
corrosive solid slowly while stirring constantly. [Unknown, (2020)]
1
, Alexandra Nedelcu Unit 4C
Equipment:
● 125 ml conical flask
● Fume hood
● Glass rod
● One Ice bath
● Vacuum filtration equipment
● Buchner funnel
● Filter paper
● 150 mL beaker
● pH paper
● 4 mL of acetic anhydride,
● NaHCO3
● 14.5 mmol of salicylic acid.
● 3 or 4 drops of conc. H2SO4
● 24 mL of NaHCO3
● 14.5 ml of 25% HCL solution
Suction filtration equipment [ Sophie,B. (2018)]
2
Aspirin synthesis
What is aspirin?
Aspirin belongs to the class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs)
(NSAIDs). It's used as a treatment for mild to moderate pain and inflammation.
Your body produces prostaglandins after you've been wounded or have an infection. Prostaglandins
produce swelling and, in some cases, fever, as well as transmitting pain signals to the brain. This is all
a natural aspect of your body's response to an injury. The swelling and fever may aid in the healing
process.
Aspirin inhibits the production of prostaglandins, which reduces pain, swelling, and fever. [Juliet,B,
(2018)]
Risk Assessment
To prevent chemical splashes and spillages, all personnel and students must wear lab coats that are
knee-length, long-sleeved, clean, and unmarked during the experiment. Tucking loose clothing inside
the lab coat or tucking it away is required, as well as wearing suitable apparel to defend against the
chemicals.
Smoking, drinking and eating is not permitted because the food could become contaminated with
the chemicals in the lab and poison you, smoking, drinking, and eating are not authorised. The lab
may have highly sensitive equipment that may be ruined if you spilled food or drink on it. The food
may contaminate the specimens being tested, which will give inaccurate results.
When latex or nitrile gloves are appropriate or required, they must be worn. Chemical resistance and
protection are greater with these gloves. It is beneficial to dispose of gloves as frequently as possible
in order to reduce contamination and maintain protection.Utilise one gloved hand to use or carry
chemicals between laboratories, and keep the other hand ungloved to open and close doors to
further prevent contamination.
During the experiment, acetic anhydride is utilised, which is a flammable material that poses a safety
risk. The following procedures are taken to minimise the dangers connected with this substance:
Keep ignition sources (sparks, smoke, flames, and hot surfaces) to a minimum when working with
flammable and combustible liquids. During the experiment, use as little flammable liquid as feasible.
Keep goods cool and dry in storage rooms. Distinguish flammable and combustible liquids from
incompatible materials (e.g., oxidizers).
Another substance is sulphuric acid, which is a corrosive chemical that can harm a person's health by
burning and destroying body tissues when it comes into touch with them. The stronger or more
concentrated the corrosive substance is, and the longer it is in contact with the body, the more
severe the injuries. Corrosive liquids should never be stored above eye level to reduce the risk of
these substances. Acids and bases should always be mixed with water (and not the reverse). Acids
and bases should be kept separate, and when mixing corrosive substances with water, add the
corrosive solid slowly while stirring constantly. [Unknown, (2020)]
1
, Alexandra Nedelcu Unit 4C
Equipment:
● 125 ml conical flask
● Fume hood
● Glass rod
● One Ice bath
● Vacuum filtration equipment
● Buchner funnel
● Filter paper
● 150 mL beaker
● pH paper
● 4 mL of acetic anhydride,
● NaHCO3
● 14.5 mmol of salicylic acid.
● 3 or 4 drops of conc. H2SO4
● 24 mL of NaHCO3
● 14.5 ml of 25% HCL solution
Suction filtration equipment [ Sophie,B. (2018)]
2
