What is Bioinformatics ?
Its the application of tools of computation and analysis to the capture
and interpretation of biological data .
(Ardeshir Bayat ,
2002 )
It's an essential tool for
combines the 4 fields of
management and extraction
computer science statistics
, ,
of DNA and protein related
biology ,
mathematics , physics .
data .
The computer programs can :
Determining gene
and protein functions .
Establish evolutionary relationships
Predict the 3D shapes of protein
Genomic data is DNA which holds
the instructions to produce proteins
to specific species .
Analysis of genomics = Genomes ,
complete set
of DNA sequences , including the transcripts (RNA) .
Analysis of proteomics Complete set of proteins
=
.
Sequencing Genomic Data
•
A primer is annealed to a sequence .
•
DNA polymerase DNTPS ddNTPs labeled with fluorophores
, ,
are added as
a mixture .
random insertion DDNTP instead of
•
During primer elongation ,
the of a a
DNTP terminates synthesis of the chain because DNA polymerase cannot
react with the missing
hydroxyl .
This produces different lengths of chains .
Its the application of tools of computation and analysis to the capture
and interpretation of biological data .
(Ardeshir Bayat ,
2002 )
It's an essential tool for
combines the 4 fields of
management and extraction
computer science statistics
, ,
of DNA and protein related
biology ,
mathematics , physics .
data .
The computer programs can :
Determining gene
and protein functions .
Establish evolutionary relationships
Predict the 3D shapes of protein
Genomic data is DNA which holds
the instructions to produce proteins
to specific species .
Analysis of genomics = Genomes ,
complete set
of DNA sequences , including the transcripts (RNA) .
Analysis of proteomics Complete set of proteins
=
.
Sequencing Genomic Data
•
A primer is annealed to a sequence .
•
DNA polymerase DNTPS ddNTPs labeled with fluorophores
, ,
are added as
a mixture .
random insertion DDNTP instead of
•
During primer elongation ,
the of a a
DNTP terminates synthesis of the chain because DNA polymerase cannot
react with the missing
hydroxyl .
This produces different lengths of chains .
