Pharmacodynamics
&
Drug Metabolism
, What is pharmacodynamics
Pharmacodynamics is about how drugs produce the
pharmacological effect.
In fact pharmacodynamics is what drugs do to the body.
The following aspects will be considered under pharmacodynamics.
Qualitative aspects Quantitative aspects
Receptors Dose response
Enzymes Potency
Selectivity Therapeutic efficacy
Tolerance
, Drugs act via the following mechanisms
1. Via receptors
Agonist
Antagonist
Partial agonist
2. By altering effects of endogenous agonist
Physiological antagonism
Increase endogenous release
Prevent endogenous release
Inhibit re-uptake
Inhibit metabolism
3. Inhibiting transport process
4. Activating enzymes or having enzyme action
5. Inhibiting enzymes
6. By other modes of action
&
Drug Metabolism
, What is pharmacodynamics
Pharmacodynamics is about how drugs produce the
pharmacological effect.
In fact pharmacodynamics is what drugs do to the body.
The following aspects will be considered under pharmacodynamics.
Qualitative aspects Quantitative aspects
Receptors Dose response
Enzymes Potency
Selectivity Therapeutic efficacy
Tolerance
, Drugs act via the following mechanisms
1. Via receptors
Agonist
Antagonist
Partial agonist
2. By altering effects of endogenous agonist
Physiological antagonism
Increase endogenous release
Prevent endogenous release
Inhibit re-uptake
Inhibit metabolism
3. Inhibiting transport process
4. Activating enzymes or having enzyme action
5. Inhibiting enzymes
6. By other modes of action
