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NURS 531 PHARMACOTHERAPEUTICS NOTES

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NURS 531 PHARMACOTHERAPEUTICS NOTES 1. More drugs metabolized by CYP3A4 greater than any other P450 enzyme = increased drug-drug interaction 2. Factors that regulate Css (serum conc), with this ADME is same to check maintenance dose = increase drug increase Css plasma levels 3. Induction of CYP450 Enzyme increased # of enzymes, increased intrinsic? activity increased rate of metabolism = increase metabolic rate decrease amount of purest? drug

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