NURS 231/NURS231 Module 3 V2 |
Pathophysiology Q&A with Rationale | Portage
Learning
1. A patient presents with a deep laceration that is being left open to heal without surgical
closure. Which type of wound healing does this represent?
A. Secondary intention
B. Primary intention
C. Tertiary intention
D. Quaternary intention
Correct Answer: A
Explanation: Secondary intention occurs when a wound is left open to heal by the
formation of granulation tissue and eventual epithelialization. This process is common in
large wounds, infections, or necrotic tissue where the edges cannot be approximated. It
typically results in slower healing and more extensive scarring compared to primary
intention.
2. Which mediator of inflammation is responsible for the immediate vasodilation and
increased vascular permeability seen in acute inflammation?
A. Histamine
B. Cytokines
,C. Leukotrienes
D. Prostaglandins
Correct Answer: A
Explanation: Histamine is one of the first mediators released during an inflammatory
response, primarily from mast cells. It causes rapid vasodilation of arterioles and increases
the permeability of venules. This response facilitates the movement of fluid and immune
cells into the interstitial space.
3. During the proliferative phase of wound healing, which cell type is primarily responsible for
secreting collagen to build new connective tissue?
A. Macrophages
B. Neutrophils
C. Endothelial cells
D. Fibroblasts
Correct Answer: D
Explanation: Fibroblasts are the key cells in the proliferative phase, producing collagen
and other extracellular matrix components. They are also involved in the secretion of
growth factors that stimulate angiogenesis. Without proper fibroblast function, the
structural integrity of the healing wound would be compromised.
, 4. Which type of hypersensitivity reaction is mediated by IgE antibodies and involves the
release of histamine from mast cells?
A. Type IV
B. Type II
C. Type III
D. Type I
Correct Answer: D
Explanation: Type I hypersensitivity is an immediate reaction triggered when an allergen
reacts with IgE antibodies bound to mast cells. This interaction causes the mast cells to
degranulate and release inflammatory mediators like histamine. Common examples
include allergic rhinitis, asthma, and systemic anaphylaxis.
5. A client is diagnosed with systemic lupus erythematosus (SLE). This condition is
characterized by the deposition of antigen-antibody complexes in various tissues,
representing which type of hypersensitivity?
A. Type I
B. Type II
C. Type IV
D. Type III
Correct Answer: D
Pathophysiology Q&A with Rationale | Portage
Learning
1. A patient presents with a deep laceration that is being left open to heal without surgical
closure. Which type of wound healing does this represent?
A. Secondary intention
B. Primary intention
C. Tertiary intention
D. Quaternary intention
Correct Answer: A
Explanation: Secondary intention occurs when a wound is left open to heal by the
formation of granulation tissue and eventual epithelialization. This process is common in
large wounds, infections, or necrotic tissue where the edges cannot be approximated. It
typically results in slower healing and more extensive scarring compared to primary
intention.
2. Which mediator of inflammation is responsible for the immediate vasodilation and
increased vascular permeability seen in acute inflammation?
A. Histamine
B. Cytokines
,C. Leukotrienes
D. Prostaglandins
Correct Answer: A
Explanation: Histamine is one of the first mediators released during an inflammatory
response, primarily from mast cells. It causes rapid vasodilation of arterioles and increases
the permeability of venules. This response facilitates the movement of fluid and immune
cells into the interstitial space.
3. During the proliferative phase of wound healing, which cell type is primarily responsible for
secreting collagen to build new connective tissue?
A. Macrophages
B. Neutrophils
C. Endothelial cells
D. Fibroblasts
Correct Answer: D
Explanation: Fibroblasts are the key cells in the proliferative phase, producing collagen
and other extracellular matrix components. They are also involved in the secretion of
growth factors that stimulate angiogenesis. Without proper fibroblast function, the
structural integrity of the healing wound would be compromised.
, 4. Which type of hypersensitivity reaction is mediated by IgE antibodies and involves the
release of histamine from mast cells?
A. Type IV
B. Type II
C. Type III
D. Type I
Correct Answer: D
Explanation: Type I hypersensitivity is an immediate reaction triggered when an allergen
reacts with IgE antibodies bound to mast cells. This interaction causes the mast cells to
degranulate and release inflammatory mediators like histamine. Common examples
include allergic rhinitis, asthma, and systemic anaphylaxis.
5. A client is diagnosed with systemic lupus erythematosus (SLE). This condition is
characterized by the deposition of antigen-antibody complexes in various tissues,
representing which type of hypersensitivity?
A. Type I
B. Type II
C. Type IV
D. Type III
Correct Answer: D
