Nur 211 Practice Questions with Correct
Answers
Hypersensitivity Type I
Immediate IgE mediated reaction
Second exposure reaction
IgE attach to mast cells and facilitate cell degranulation and histamine release
Which type of WBC increased in Type 1
Eosinophils norm 1-2% reaction can be >12%
TI reaction tx
Steroid to decrease immune response
Antihistamine 1st gen cross blood-brain barrier
B1 agonist to open airway
Epi
Hypersensitivity Type II
Cytotoxic (antibody mediated)
IgM IgG
Complement system is activated
Subtype 1 of type 2 reaction
Ex-transfusion reaction.
cells marked for phagocytosis
cell lysis
Subtype 2 of type 2
, Complement and antibody mediated reaction
Ex-goodpasture attacks the GBM causing inflammation r/t deposits of IgG in glomerular and
alveolar tissue
Subtype 3 of type 2
Antibody binds to cell surface receptor.
Ex-Myasthenia gravis, antibody binds to acetylcholine receptors
Type 2 tx
Plasmapheresis
Type 3 reaction
Immune complex (antibody-antigen complex) hard to discard and end up depositing in a
tissue
Ex-SLE and RA
Type 4 reaction
T lymphocyte mediated
- occur 12 to 72 hrs after exposure
- s/s: eosinophilia, SJS
Who is at risk for RA
Female
Native american
30-50yo
Smokers, bacteria/virus exposure
RA presentation
Answers
Hypersensitivity Type I
Immediate IgE mediated reaction
Second exposure reaction
IgE attach to mast cells and facilitate cell degranulation and histamine release
Which type of WBC increased in Type 1
Eosinophils norm 1-2% reaction can be >12%
TI reaction tx
Steroid to decrease immune response
Antihistamine 1st gen cross blood-brain barrier
B1 agonist to open airway
Epi
Hypersensitivity Type II
Cytotoxic (antibody mediated)
IgM IgG
Complement system is activated
Subtype 1 of type 2 reaction
Ex-transfusion reaction.
cells marked for phagocytosis
cell lysis
Subtype 2 of type 2
, Complement and antibody mediated reaction
Ex-goodpasture attacks the GBM causing inflammation r/t deposits of IgG in glomerular and
alveolar tissue
Subtype 3 of type 2
Antibody binds to cell surface receptor.
Ex-Myasthenia gravis, antibody binds to acetylcholine receptors
Type 2 tx
Plasmapheresis
Type 3 reaction
Immune complex (antibody-antigen complex) hard to discard and end up depositing in a
tissue
Ex-SLE and RA
Type 4 reaction
T lymphocyte mediated
- occur 12 to 72 hrs after exposure
- s/s: eosinophilia, SJS
Who is at risk for RA
Female
Native american
30-50yo
Smokers, bacteria/virus exposure
RA presentation