COMSAE 107 Exam Questions with 100%
Correct Answers
What virulence factor do gram negative rods share? How will it affect patients?
Gram negative rods share lipopolysaccharide capsule; lipid A can cause septic shock in
patients.
What virulence factors do gram positive bacteria share?
Gram positive bacteria share lipoteichoic acid and teichoic acid.
If a patient with a history of stroke has intolerance to aspirin, what drug can they
switch to? What is the MOA? What are associated AEs to be aware of?
Switch to ticlopidine; MOA: inhibits ADP activation of platelets; AEs: can induce TTP and
neutropenia.
Describe how a leiomyoma presents on biopsy.
Leiomyoma appears encapsulated, composed of interlacing bundles of spindle cells, with no
atypia or mitosis.
Are cerebellar symptoms ipsilateral or contralateral?
Cerebellar symptoms are ipsilateral.
If a patient presents with cyclic headaches after traveling, what should you immediately
be thinking of?
Malaria.
How does a patient with fragile X present? What is the molecular association? What is
the inheritance pattern? What gene is involved?
,Fragile X presents with macroorchidism, facial abnormalities, autism-like symptoms;
associated with mutation of FMR1 gene; inheritance pattern is X-linked; trinucleotide
expansion: CGG.
What labs are associated with factor VII deficiency?
Prolonged PT, all else is normal.
What labs are associated with GpIIb/IIIa receptor deficiency?
Prolonged bleeding time, all else is normal.
What labs are associated with hemophilia A?
Prolonged PTT; deficiency in factor VIII.
What labs are associated with hemophilia B?
Prolonged PTT; deficiency in factor IX.
What labs are associated with von Willebrand disease?
Prolonged PTT and bleeding time.
What is the diagnosis for a patient presenting with diarrhea, right-sided abdominal
pain, postprandial cramping, and weight loss with a positive fecal occult blood test?
Diagnosis is Crohn's disease.
What is the treatment for Crohn's disease?
Treatment is sulfasalazine.
How does rheumatoid arthritis present?
Rheumatoid arthritis presents as symmetric, inflammatory, affecting small joints, anti-CCP
positive, usually in ages 30-50.
, How does polymyalgia rheumatica present?
Polymyalgia rheumatica usually presents in patients over 50 with bilateral shoulder/hip
stiffness, high ESR, normal CK, and dramatic response to steroids.
If a patient has severe watery diarrhea and stool sample reveals toxins A and B, what is
the diagnosis? What is the treatment?
Diagnosis is C. difficile; treatment is oral vancomycin.
What drug is likely being taken by a patient with longstanding hypertension who now
has right big toe pain and a uric acid level of 9.2?
The drug is hydrochlorothiazide.
If a 9-month-old baby presents with a history of recurrent ear infections and tonsillitis
over the past 6 months, what antibody do they likely have inadequate production of?
IgA.
When is it appropriate to use amniocentesis as a screening tool in pregnancy?
Usually > 15 weeks for genetics and karyotyping.
When is it appropriate to use chorionic villus sampling as a screening tool in
pregnancy?
10-13 weeks for early genetic/chromosomal diagnosis.
When is it appropriate to use maternal serum AFP as a screening tool in pregnancy?
15-20 weeks to screen for neural tube defects and abdominal wall defects.
When is it appropriate to use quantitative serum B-hCG as a screening tool in
pregnancy?
Correct Answers
What virulence factor do gram negative rods share? How will it affect patients?
Gram negative rods share lipopolysaccharide capsule; lipid A can cause septic shock in
patients.
What virulence factors do gram positive bacteria share?
Gram positive bacteria share lipoteichoic acid and teichoic acid.
If a patient with a history of stroke has intolerance to aspirin, what drug can they
switch to? What is the MOA? What are associated AEs to be aware of?
Switch to ticlopidine; MOA: inhibits ADP activation of platelets; AEs: can induce TTP and
neutropenia.
Describe how a leiomyoma presents on biopsy.
Leiomyoma appears encapsulated, composed of interlacing bundles of spindle cells, with no
atypia or mitosis.
Are cerebellar symptoms ipsilateral or contralateral?
Cerebellar symptoms are ipsilateral.
If a patient presents with cyclic headaches after traveling, what should you immediately
be thinking of?
Malaria.
How does a patient with fragile X present? What is the molecular association? What is
the inheritance pattern? What gene is involved?
,Fragile X presents with macroorchidism, facial abnormalities, autism-like symptoms;
associated with mutation of FMR1 gene; inheritance pattern is X-linked; trinucleotide
expansion: CGG.
What labs are associated with factor VII deficiency?
Prolonged PT, all else is normal.
What labs are associated with GpIIb/IIIa receptor deficiency?
Prolonged bleeding time, all else is normal.
What labs are associated with hemophilia A?
Prolonged PTT; deficiency in factor VIII.
What labs are associated with hemophilia B?
Prolonged PTT; deficiency in factor IX.
What labs are associated with von Willebrand disease?
Prolonged PTT and bleeding time.
What is the diagnosis for a patient presenting with diarrhea, right-sided abdominal
pain, postprandial cramping, and weight loss with a positive fecal occult blood test?
Diagnosis is Crohn's disease.
What is the treatment for Crohn's disease?
Treatment is sulfasalazine.
How does rheumatoid arthritis present?
Rheumatoid arthritis presents as symmetric, inflammatory, affecting small joints, anti-CCP
positive, usually in ages 30-50.
, How does polymyalgia rheumatica present?
Polymyalgia rheumatica usually presents in patients over 50 with bilateral shoulder/hip
stiffness, high ESR, normal CK, and dramatic response to steroids.
If a patient has severe watery diarrhea and stool sample reveals toxins A and B, what is
the diagnosis? What is the treatment?
Diagnosis is C. difficile; treatment is oral vancomycin.
What drug is likely being taken by a patient with longstanding hypertension who now
has right big toe pain and a uric acid level of 9.2?
The drug is hydrochlorothiazide.
If a 9-month-old baby presents with a history of recurrent ear infections and tonsillitis
over the past 6 months, what antibody do they likely have inadequate production of?
IgA.
When is it appropriate to use amniocentesis as a screening tool in pregnancy?
Usually > 15 weeks for genetics and karyotyping.
When is it appropriate to use chorionic villus sampling as a screening tool in
pregnancy?
10-13 weeks for early genetic/chromosomal diagnosis.
When is it appropriate to use maternal serum AFP as a screening tool in pregnancy?
15-20 weeks to screen for neural tube defects and abdominal wall defects.
When is it appropriate to use quantitative serum B-hCG as a screening tool in
pregnancy?
