Antigen Receptor Diversity Questions with CORRECT Answers

Antigen Receptor Diversity Questions with
CORRECT Answers

Question:
clonal selection hypothesis
Answer:
each B cell bears a single type of Ig receptor with unique specificity on stimulation, each
cell will create a clone of cells bearing the same receptor as the original


Question:
pseudogenes
Answer:
former genes that have accumulated mutations and are nonfunctional


Question:
clonal expansion
Answer:
the rapid multiplication of B or T cell clones after activation by an antigen lymphocytes
binding to antigen through BCR or TCR are activated, then they proliferate and
differentiate, forming a clone of cells


Question:
combinatorial diversity
Answer:
which heavy chains pair with which light chains


Question:
junctional diversity
Answer:
created during the process of gene rearrangement by the addition or removal of
nucleotides at the junctions between gene segments


Question:
Ig gene recombination takes place in lineage on the level
Answer:
B cell, DNA

, Question:
V, D, and J gene segments can be found in cells, but recombination of these gene
segments only occurs in cells
Answer:
all, lymphocytes


Question:
polymorphism
Answer:
the coexistence of two or more distinct forms in the same population.


Question:
Ig can refer to (2)
Answer:
membrane-bound (BCRs)


Question:
loci
Answer:
point on the chromosome where the gene is found


Question:
determines Ig isotype
Answer:
C region


Question:
how does the cell ensure it picks one V, one J, and one C to join together
Answer:
by using RSSs


Question:
RSS
Answer:
recombination signal sequences that flank the site of recombination