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Exam Section 1: Item 1 of 50 National Board of ~edical Examiners
•Mark Comprehensive Basic Science Self-Assessment
1. A 14-year-old girl is brought to the physician because of a 1-month history of migraine-like headaches, vomiting, and multiple left-sided focal seizures. She has had hearing
loss since the age of 11 years Her mother and maternal grandmother have high-tone deafness. Physical examination shows loss of vision in one half of the visual field of
the. right eye and weakness of the right upper and lower extremities. Serum and cerebrospinal fluid concentrations of !actic acid are increased. This patient most likely has
a mutation of which of the following?
/>.) Endoplasmic reticulum glycosyltransferase
B) Lysosomal a-glucosidase
• C) Mitochondrial tRNAL•u
D) Nuclear proteasome activator
E) Peroxisomal catalase
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Exam Section 1: Item 2 of 50 National Board of Medical Examiners
• Mark Comprehensive Basic Science Self-Assessment
/ 2. A 32-year-old woman has had fecal incontinence since giving birth to her first child 1 year ago Which of the following is the most likely cause of the fecal incontinence in
this patient?
/'.) Achalasia of the internal anal sphincter
• B) Damage to the anal sphincter
C) Increased pressure of the anal sphincter
D) Spastic contraction of the puborectalis muscle
E) Spastic external anal sphincter
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Exam Section 1: Item 3 of 50 National Board of Medical Examiners Time Remaining:
• Mark Comprehensive Basic Science Self-Assessment 1 hr 12 min 28 sec
3. A 17-year-old gir1 comes to the emergency department because of a swollen tender ankle. An x-ray of the ankle is strongly suggestive of osteosarcoma. She and her parents are told
only that "further evaluation is needed." Which of the following next steps is most appropriate?
0 A) Request that an oncologist discuss the findings with them immediately
0 B) Request the presence of the hospital chaplain, then discuss the findings
0 C) Speak with the parents alone about the findings
0 D) Speak with the patient alone about the findings
0 E) Speak with the patient and her parents about the findings
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Exam Section 1: Item 4 of 50 National Board of Medical Examiners Time Remaining:
• Mark Comprehensive Basic Science Self-Assessment 1 hr 12 min 25 sec
4. An otheiwise healthy 16-year-old girl comes to the physician because of a 2-month history of episodes of wheezing and shortness of breath while participating in track meets with her
high school team. Her respirations are 12/min. Physical examination shows no abnormal~ies. A diagnosis of exercise-induced asthma is made. Exposure to which of the following is
most likely to precipitate a similar episode in this patient in the future?
0 A) Cold, dry air
0 B) Cold, moist air
0 C) Warm, dry air
0 D) Warm, moist air
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