RN PHARMACOLOGY A RELIAS
EVALUATION BANK 2026 COMPLETE
ANSWERS GRADED A+
⩥ pharmacodynamics.
Answer: relationship between drug concentration over time and
therapeutic response
⩥ chemical specificity for receptors.
Answer: specificity between receptors and bonds, EX strict structural
requirements for binding
⩥ receptor saturability.
Answer: only a finite number of receptors that can be occupied
⩥ receptor affinity.
Answer: measure of attraction between drug and receptor
⩥ drug potency.
Answer: dose required to have certain effect, related to affinity of
receptor
,⩥ ED50.
Answer: dose which produces 50% of maximum effect, used to compare
drugs in terms of potency
⩥ drug efficacy.
Answer: maximal effect achievable for a drug, related to number of
receptor/complexes formed, intrinsic activity of drug in activating
receptor
⩥ full agonist.
Answer: affinity to, and full activator, of receptor (high intrinsic
activity/efficacy), increases activity above basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
⩥ inverse agonist.
Answer: affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full agonist
(metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
⩥ partial agonist.
Answer: affinity to receptor but only partially activates a receptor,
produces less than the ceiling effect of a full agonist
, ⩥ pure antagonist.
Answer: affinity to receptor but produces no activation, dose curve is a
straight line across the bottom of an XY graph (EX oraverse vasodilates,
overcoming the vasocontriction of the LA)
⩥ neutral antgonist.
Answer: has no activity in the absence of an agonist or inverse agonist
but can block either's activity
⩥ competitive antagonist.
Answer: lacks efficacy, competes with agonists for binding sites,
inhibitory effect can be overcome by increasing concentration of
competing agonist
⩥ every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is different
for every patient.
Answer:
⩥ know the second slide on page 10 of principles of drugs.
Answer: which drugs is most potent, least potenet, most efficient and
least efficient
EVALUATION BANK 2026 COMPLETE
ANSWERS GRADED A+
⩥ pharmacodynamics.
Answer: relationship between drug concentration over time and
therapeutic response
⩥ chemical specificity for receptors.
Answer: specificity between receptors and bonds, EX strict structural
requirements for binding
⩥ receptor saturability.
Answer: only a finite number of receptors that can be occupied
⩥ receptor affinity.
Answer: measure of attraction between drug and receptor
⩥ drug potency.
Answer: dose required to have certain effect, related to affinity of
receptor
,⩥ ED50.
Answer: dose which produces 50% of maximum effect, used to compare
drugs in terms of potency
⩥ drug efficacy.
Answer: maximal effect achievable for a drug, related to number of
receptor/complexes formed, intrinsic activity of drug in activating
receptor
⩥ full agonist.
Answer: affinity to, and full activator, of receptor (high intrinsic
activity/efficacy), increases activity above basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
⩥ inverse agonist.
Answer: affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full agonist
(metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
⩥ partial agonist.
Answer: affinity to receptor but only partially activates a receptor,
produces less than the ceiling effect of a full agonist
, ⩥ pure antagonist.
Answer: affinity to receptor but produces no activation, dose curve is a
straight line across the bottom of an XY graph (EX oraverse vasodilates,
overcoming the vasocontriction of the LA)
⩥ neutral antgonist.
Answer: has no activity in the absence of an agonist or inverse agonist
but can block either's activity
⩥ competitive antagonist.
Answer: lacks efficacy, competes with agonists for binding sites,
inhibitory effect can be overcome by increasing concentration of
competing agonist
⩥ every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is different
for every patient.
Answer:
⩥ know the second slide on page 10 of principles of drugs.
Answer: which drugs is most potent, least potenet, most efficient and
least efficient
