1. Endothelial
Outline the 4 structures that filtered blood material has to
2. GBM
cross to enter the tubular lumen (from blood to tubule):
3. Podocytes
Discuss the Endothelial Cell characteristics: They have fenestrae of 60-100nm
Collagen Type IV and polyanionic GAGs. They have a
Discuss the GBM characteristics: strong negative charge which will repel albumin. They also
have a size selection of 40nm
They have foot processes with slit diaphrahms of
Discuss Podocyte Characteristics: Nephrin and Podosin. The size-selectionof the Podocyte
is 20-30nm
1. Majority of GNs are dittuse and global
2. Concentric GN can be dittuse or focal
Discuss the glomerular mass involvement of major
3. Lupus Nephritis can be either also
Glomerulonephropathies:
4. Focal Segmental Glomerulosclerosis is a special type of
Primary GN
Hypercellularity of Parietal Epithelial Cells of the Bowman's
Capsule.
What causes the crescent formation of the Bowman Cap- This is seen in Rapidly Progressive GlomeruloNephritis
sule?
Identify Wire-Loop basement membrane change in
Glomerulonephritis:
Identify Segmental Sclerosis or Hyalinization in Glomeru-
lonephritis:
, Identify the "Hump" in Poststreptococcal Glomeru-
lonephritis:
1. (Antibody mediated)In-situ immune complex deposi-
tion
What are the immune mechanisms of Glomerular Injury? 2. Circulating Immune Complexes
3. Cell mediated immune injury
4. activation of alternative complement pathway
What are the two types of Antibody Mediated In-Situ Im- 1. Fixed Intrinsic Tissue Antigen
mune Complex Deposition? 2. Planted Antigen
1. NC1 Domain of Collagen IV Ag (Anti-GBM)
2. Heyman Ag (Membranous GN)
What are the Fixed Intrinsic Tissue Antigens?
3. Mesangial Ags
4. Others
Exogenous such as infection or drugs
What are the Planted Antigens?
Endogenous Ags such as DNA, Proteins, IgS
IgA Nephropathy usually associated with isolated hema-
What is the most common primary glomerular disease?
turia/proteinuria
Berger Disease. It is the most common GN in the world.
Hematuria, mild proteinuria, occasional nephrotic syn-
What is IgA Nephropathy?
drome
May present with Cresentic RPGN
IgA nephropathy and systemic vasculitis. There are pur-
puric skin lesions, abdominal pain, vomiting, intestinal
bleeding, and arthralgia.
What is Henoch-Shonlein Purpura?
Outline the 4 structures that filtered blood material has to
2. GBM
cross to enter the tubular lumen (from blood to tubule):
3. Podocytes
Discuss the Endothelial Cell characteristics: They have fenestrae of 60-100nm
Collagen Type IV and polyanionic GAGs. They have a
Discuss the GBM characteristics: strong negative charge which will repel albumin. They also
have a size selection of 40nm
They have foot processes with slit diaphrahms of
Discuss Podocyte Characteristics: Nephrin and Podosin. The size-selectionof the Podocyte
is 20-30nm
1. Majority of GNs are dittuse and global
2. Concentric GN can be dittuse or focal
Discuss the glomerular mass involvement of major
3. Lupus Nephritis can be either also
Glomerulonephropathies:
4. Focal Segmental Glomerulosclerosis is a special type of
Primary GN
Hypercellularity of Parietal Epithelial Cells of the Bowman's
Capsule.
What causes the crescent formation of the Bowman Cap- This is seen in Rapidly Progressive GlomeruloNephritis
sule?
Identify Wire-Loop basement membrane change in
Glomerulonephritis:
Identify Segmental Sclerosis or Hyalinization in Glomeru-
lonephritis:
, Identify the "Hump" in Poststreptococcal Glomeru-
lonephritis:
1. (Antibody mediated)In-situ immune complex deposi-
tion
What are the immune mechanisms of Glomerular Injury? 2. Circulating Immune Complexes
3. Cell mediated immune injury
4. activation of alternative complement pathway
What are the two types of Antibody Mediated In-Situ Im- 1. Fixed Intrinsic Tissue Antigen
mune Complex Deposition? 2. Planted Antigen
1. NC1 Domain of Collagen IV Ag (Anti-GBM)
2. Heyman Ag (Membranous GN)
What are the Fixed Intrinsic Tissue Antigens?
3. Mesangial Ags
4. Others
Exogenous such as infection or drugs
What are the Planted Antigens?
Endogenous Ags such as DNA, Proteins, IgS
IgA Nephropathy usually associated with isolated hema-
What is the most common primary glomerular disease?
turia/proteinuria
Berger Disease. It is the most common GN in the world.
Hematuria, mild proteinuria, occasional nephrotic syn-
What is IgA Nephropathy?
drome
May present with Cresentic RPGN
IgA nephropathy and systemic vasculitis. There are pur-
puric skin lesions, abdominal pain, vomiting, intestinal
bleeding, and arthralgia.
What is Henoch-Shonlein Purpura?
