1|Page
NURS 615 PHARM EXAM BANK COMPILATION / 3
& 4 MARYVILLE||VERIFIED EXAM!!||
COMPREHENSIVE STUDY GUIDE – EXPERT
STRATEGIES, REVIEW PRACTICE QUESTIONS FOR
GUARANTEED SUCCESS / NEWEST 2026/2027 NURS
615 PHARM EXAM 1
According to the WHO what is the first step in the
prescribing process? - Answer-The first step is to define
the patient's problem
The second step is to - Answer-specify the therapeutic
objective
The third step is to - Answer-choose which drug or
treatment is needed.
Step 4 of the WHO approach: - Answer-Start the treatment
Step 5 of the WHO approach: - Answer-Educate the
patient
,2|Page
Step 6 of the WHO approach: - Answer-Monitor the
treatment
Phase 1 of drug development: - Answer-The drug is tested
on healthy volunteers
Phase 2 of drug development: - Answer-trials with people
who have the disease for which the drug is thought to be
effective
Phase 3 of drug development: - Answer-Large numbers of
patients in medical research centers receive the drug in
phase 3. This larger sampling provides information about
infrequent or rare adverse effects. The FFA will approve a
new drug application if phase 3 studies are satisfactory.
Phase 4 of drug development: - Answer-This phase is
voluntary and involves postmarket surveillance of the
drug's therapeutic effects at the completion of phase 3.
The pharmaceutical company receives reports from
doctors and other health care professionals about the
therapeutic results and adverse effects of the drug. Some
medications, for example, have been found to be toxic and
,3|Page
have been removed from the market after their initial
release.
Explain first pass metabolism - Answer-much of the drug is
lost in the absorption process. The liver metabolizes many
drugs, thus reduces the bioavailabilty of the drug.
What is the fasted route of absorption: - Answer-The
fastest route of absorption is inhalation, and not as
mistakenly considered the IV administration.
Why does the GI tract take longer to absorb? - Answer-
The GI tract is lined with epithelial cells; drugs must
permeate through these cells in order to be absorbed into
the circulatory system.
What is One particular cellular barrier that may prevent
absorption of a given drug? - Answer-the cell membrane.
Cell membranes are essentially lipid bilayers which form a
semipermeable membrane. Pure lipid bilayers are
generally permeable only to small and uncharged solutes,
hence whether or not a molecule is ionized will affect its
absorption, since ionic molecules are charged.
, 4|Page
What is solubility? - Answer-Solubility favors charged
species, permeability favors neutral species. Some
molecules have special exchange proteins and channels
to facilitate movement from the lumen into the circulation.
Why does absorption occur at a slower rate for oral, IM,
SQ routes? - Answer-Absorption occurs at a slower rate
because the complex membrane systems of GI mucosal
layers, muscle, and skin delay drug passage.
The ability of a drug to cross a cell membrane depends
on: - Answer-whether the drug is water or lipid (fat)
soluble. Lipid-soluble drugs easily cross through cell
membranes; water-soluble drugs can't. Lipid-soluble drugs
can also cross the blood-brain barrier and enter the brain.
As a drug travels through the body, it comes in contact
with? - Answer-proteins such as the plasma protein
albumin. The drug can remain free or bind to the protein.
The portion of a drug that's bound to a protein is inactive
and can't exert a therapeutic effect. Only the free, or
unbound, portion remains active. A drug is said to be
highly protein-bound if more than 80% of the drug is
bound to protein.
NURS 615 PHARM EXAM BANK COMPILATION / 3
& 4 MARYVILLE||VERIFIED EXAM!!||
COMPREHENSIVE STUDY GUIDE – EXPERT
STRATEGIES, REVIEW PRACTICE QUESTIONS FOR
GUARANTEED SUCCESS / NEWEST 2026/2027 NURS
615 PHARM EXAM 1
According to the WHO what is the first step in the
prescribing process? - Answer-The first step is to define
the patient's problem
The second step is to - Answer-specify the therapeutic
objective
The third step is to - Answer-choose which drug or
treatment is needed.
Step 4 of the WHO approach: - Answer-Start the treatment
Step 5 of the WHO approach: - Answer-Educate the
patient
,2|Page
Step 6 of the WHO approach: - Answer-Monitor the
treatment
Phase 1 of drug development: - Answer-The drug is tested
on healthy volunteers
Phase 2 of drug development: - Answer-trials with people
who have the disease for which the drug is thought to be
effective
Phase 3 of drug development: - Answer-Large numbers of
patients in medical research centers receive the drug in
phase 3. This larger sampling provides information about
infrequent or rare adverse effects. The FFA will approve a
new drug application if phase 3 studies are satisfactory.
Phase 4 of drug development: - Answer-This phase is
voluntary and involves postmarket surveillance of the
drug's therapeutic effects at the completion of phase 3.
The pharmaceutical company receives reports from
doctors and other health care professionals about the
therapeutic results and adverse effects of the drug. Some
medications, for example, have been found to be toxic and
,3|Page
have been removed from the market after their initial
release.
Explain first pass metabolism - Answer-much of the drug is
lost in the absorption process. The liver metabolizes many
drugs, thus reduces the bioavailabilty of the drug.
What is the fasted route of absorption: - Answer-The
fastest route of absorption is inhalation, and not as
mistakenly considered the IV administration.
Why does the GI tract take longer to absorb? - Answer-
The GI tract is lined with epithelial cells; drugs must
permeate through these cells in order to be absorbed into
the circulatory system.
What is One particular cellular barrier that may prevent
absorption of a given drug? - Answer-the cell membrane.
Cell membranes are essentially lipid bilayers which form a
semipermeable membrane. Pure lipid bilayers are
generally permeable only to small and uncharged solutes,
hence whether or not a molecule is ionized will affect its
absorption, since ionic molecules are charged.
, 4|Page
What is solubility? - Answer-Solubility favors charged
species, permeability favors neutral species. Some
molecules have special exchange proteins and channels
to facilitate movement from the lumen into the circulation.
Why does absorption occur at a slower rate for oral, IM,
SQ routes? - Answer-Absorption occurs at a slower rate
because the complex membrane systems of GI mucosal
layers, muscle, and skin delay drug passage.
The ability of a drug to cross a cell membrane depends
on: - Answer-whether the drug is water or lipid (fat)
soluble. Lipid-soluble drugs easily cross through cell
membranes; water-soluble drugs can't. Lipid-soluble drugs
can also cross the blood-brain barrier and enter the brain.
As a drug travels through the body, it comes in contact
with? - Answer-proteins such as the plasma protein
albumin. The drug can remain free or bind to the protein.
The portion of a drug that's bound to a protein is inactive
and can't exert a therapeutic effect. Only the free, or
unbound, portion remains active. A drug is said to be
highly protein-bound if more than 80% of the drug is
bound to protein.
