Comprehensive Clinical
Chemistry and Laboratory
Medicine Review
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** Questions with Verified Answer
** New Edition | 2026-2027 Updated
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, What are the diagnostic criteria for 1. Hemoglobin A1C > 6.5% 2. Fasting plasma
Diabetes Mellitus? glucose (FPG) > 126 mg/dL 3. Symptoms of
hyperglycemia (polyuria, polydipsia, unexplained
weight loss) with random plasma glucose > 200
mg/dL 4. 2-hour plasma glucose > 200 mg/dL
during an OGTT.
What are the diagnostic criteria for 1. Fasting plasma glucose 100-125 mg/dL
Prediabetes? (Impaired Fasting Glucose) 2. 2-hour plasma
glucose 140-199 mg/dL during an OGTT (Impaired
Glucose Tolerance) 3. Hemoglobin A1C 5.7-6.4%.
What is the procedure for an Oral 1. Fasting blood glucose is drawn 2. 50-75 grams
Glucose Tolerance Test (OGTT)? of glucose is given orally 3. Blood is collected at
0.5, 1, 2, and 3 hours and tested for glucose.
What does HbA1C measure? It measures glycated hemoglobin, providing an
index of integrated plasma glucose values over
approximately 3 months.
What specimen is used for HbA1C Whole blood, collected in a lavender top tube
testing? (EDTA as anticoagulant).
What factors can impact hemoglobin Hemodialysis, pregnancy, HIV treatment, anemia,
glycation? and hemoglobinopathies.
What is the role of Insulin in glucose Insulin decreases blood glucose levels by
regulation? increasing glycogenesis and lipogenesis, and
decreasing glycogenolysis.
How does Growth Hormone affect It increases blood glucose levels by promoting
blood glucose levels? glycogenolysis.
What is Glycogenolysis? The process of converting hepatic glycogen to
glucose, which increases blood glucose levels.
What is Glycogenesis? The conversion of glucose to glycogen for storage,
which decreases blood glucose levels.