Chapter 11 and 12 Rau's
Respiratory Care Pharmacology
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, A significant side effect of corticosteroid use is inhibition C. HPA Axis
of
a. IgE. When the body produces endogenous glucocorticoids, there is a normal
b. PDE. feedback mechanism within the hypothalamic-pituitary-adrenal (HPA) axis to limit
c. HPA axis. production. As glucocorticoid levels increase, the release of corticotropin-
d. SRS-A. releasing factor (CRF) and adrenocorticotropic hormone (ACTH) is inhibited, and
further adrenal production is stopped. Because the body cannot distinguish
between its own endogenous glucocorticoids and exogenous glucocorticoid
drugs, steroid administration can inhibit the hypothalamus and pituitary glands,
decreasing adrenal production. Immunoglobulin E (IgE), phosphodiesterase
(PDE), and slow-reacting substance of anaphylaxis (SRS-A) are not involved in
this process
Which of the following is produced in the hypothalamus? B. Corticotroping-releasing.
a. Glucocorticoids
b. Corticotropin-releasing factor Three types of corticosteroid hormones are produced by the adrenal cortex:
c. Mineralocorticoids glucocorticoids, mineralocorticoids, and sex hormones. Corticotropin-releasing
d. Sex hormones factor (CRF) is released from the hypothalamus.
Which of the following is produced in the hypothalamus? B. Corticotropin-releasing factor.
a. Glucocorticoids
b. Corticotropin-releasing factor Three types of corticosteroid hormones are produced by the adrenal cortex:
c. Mineralocorticoids glucocorticoids, mineralocorticoids, and sex hormones. Corticotropin-releasing
d. Sex hormones factor (CRF) is released from the hypothalamus
Corticosteroids normally produced by the body are A. endogenous
known as
a. endogenous. Endogenous corticosteroids are produced inside the human body, whereas
b. exogenous. exogenous corticosteroids are produced outside the body
c. extrinsic.
d. intrinsic.
Which of the following are examples of steroids or D. !,2,3 and 4
steroid combinations available for inhalation?
1. AeroSpan Brand names of corticosteroids available by aerosol for oral inhalation include
2. Flovent Qvar, AeroSpan, Asmanex, Flovent, Pulmicort, and Advair. Interleukins are
3. Qvar cytokines released by the human body
4. Advair
a. 1, 2, and 3 only
b. 1 and 2 only
c. 2 and 3 only
d. 1, 2, 3, and 4
The rise and fall of levels of glucocorticoids in the body C. CIrcadian
follow what kind of rhythm?
a. Weekly The production of the body's own glucocorticoids follows a rhythmic cycle,
b. Monthly termed a diurnal or circadian rhythm.
c. Circadian
d. No set rhythm
The inflammatory process includes which of the following D. 1,2,3 and 4
activities? The process of inflammation is caused by the following four major categories of
1. Mediator cascade activity: 1. Mediator cascade 2. Increased vascular permeability 3. Leukocytic
2. Increased vascular permeability infiltration 4. Phagocytosis
3. Leukocytic infiltration
4. Phagocytosis
a. 1 and 2 only
b. 2 and 3 only
c. 1, 2, and 4 only
d. 1, 2, 3, and 4
The major cells responsible for an inflammatory B. Mast cells and eosinophils
response in asthma are
a. macrophages and mast cells. are considered the major effector cells of the inflammatory response, regardless
b. mast cells and eosinophils. of whether asthma is allergic or
c. T lymphocytes and macrophages.
d. basophils and SRS-A
The early phase of an asthmatic reaction occurs during A. 15 minutes to 1 hr.
what time frame? The early-phase reaction, during which IgE-dependent activation of mast cells
a. 15 minutes to 1 hour releases inflammatory mediators such as histamine, prostaglandin D2, and
b. 2-4 hours leukotriene C4, peaks at about 15 minutes and then declines over the next hour.
c. 6-8 hours
d. 24 hours