Chamberlain University
OIB · 2A ISEH
★ ★
College of Nursing & Public Health
C
A C A D E M I C E X C E L L E N C E · I N N O V AT I O N · I N T E G R I T Y · W O R L D C L A S S
EST. 1889
SERVICE
Hesi A2 Biology
B I O LO G Y — CO M P R E H E N S I V E R E V I E W
INSTITUTION Chamberlain University PROGRAM Pre-Nursing / Allied Health
COURSE CODE HESI A2 COURSE TITLE Biology
ACADEMIC YEAR EXAM TITLE Hesi A2 Biology
TOTAL QUESTIONS 369 Questions FORMAT Multiple Choice — Select the
Single Best Answer
EXAMINATION INSTRUCTIONS
▸ Select the single best answer for each biology question.
▸ Topics include cell biology, genetics, metabolism, and plant biology.
▸ Focus on understanding key concepts and processes.
▸ Correct answers and rationales appear below each question.
▸ This comprehensive review covers all HESI A2 biology content.
, SECTION I — BIOLOGY: CELLS, GENETICS, METABOLISM
Questions 1 – 369
& MORE
1. How many chromosomes do sperm and egg produce in meiosis?
A. 23
B. 46
C. 92
D. 12
CORRECT ANSWER A — 23
RATIONALE Meiosis produces gametes (sperm and egg) with half the number of
chromosomes, resulting in 23 chromosomes in humans. This haploid number
ensures that fertilization restores the diploid number of 46 chromosomes.
2. How many chromosomes do sperm and egg produce in mitosis?
A. 23
B. 46
C. 92
D. 24
CORRECT ANSWER B — 46
RATIONALE Mitosis produces daughter cells with the same number of chromosomes as the
parent cell. In humans, this means 46 chromosomes (23 pairs) in each daughter
cell.
,3. What helps the cell shape and cell to adapt?
A. Cytoskeleton
B. Nucleus
C. Mitochondria
D. Ribosomes
CORRECT ANSWER A — Cytoskeleton
RATIONALE The cytoskeleton is a network of protein filaments that helps maintain cell shape,
provides mechanical support, and enables cell movement and adaptation to
environmental changes.
4. What gives the cell the ability to move and proper?
A. Microtubules
B. Ribosomes
C. Lysosomes
D. Vacuoles
CORRECT ANSWER A — Microtubules
RATIONALE Microtubules are components of the cytoskeleton that provide structural support,
facilitate intracellular transport, and enable cell movement through structures
like cilia and flagella.
5. What is the main component of blood plasma?
A. Water
B. Proteins
C. Lipids
D. Carbohydrates
CORRECT ANSWER A — Water
RATIONALE Blood plasma is approximately 90-92% water, with the remainder consisting of
dissolved proteins, electrolytes, nutrients, and waste products. Water is the main
component that allows plasma to transport substances throughout the body.
, 6. What is the first step in metabolism of food to cellular energy?
A. Glycolysis
B. Krebs cycle
C. Electron transport chain
D. Fermentation
CORRECT ANSWER A — Glycolysis
RATIONALE Glycolysis is the first step in the metabolism of food to cellular energy. It occurs in
the cytosol and converts glucose into pyruvate, producing ATP and NADH.
7. What drives the cell / pushes it forward?
A. Propulsion
B. Diffusion
C. Osmosis
D. Active transport
CORRECT ANSWER A — Propulsion
RATIONALE Propulsion refers to the ability of cells to move or be moved forward. In cells, this
can be achieved through structures like flagella and cilia, which provide motility.
8. All humans have how many pairs of chromosomes?
A. 23 pairs
B. 22 pairs
C. 24 pairs
D. 46 pairs
CORRECT ANSWER A — 23 pairs
RATIONALE Humans have 23 pairs of chromosomes (22 pairs of autosomes and 1 pair of sex
chromosomes), for a total of 46 chromosomes. Each pair consists of one
chromosome from each parent.
OIB · 2A ISEH
★ ★
College of Nursing & Public Health
C
A C A D E M I C E X C E L L E N C E · I N N O V AT I O N · I N T E G R I T Y · W O R L D C L A S S
EST. 1889
SERVICE
Hesi A2 Biology
B I O LO G Y — CO M P R E H E N S I V E R E V I E W
INSTITUTION Chamberlain University PROGRAM Pre-Nursing / Allied Health
COURSE CODE HESI A2 COURSE TITLE Biology
ACADEMIC YEAR EXAM TITLE Hesi A2 Biology
TOTAL QUESTIONS 369 Questions FORMAT Multiple Choice — Select the
Single Best Answer
EXAMINATION INSTRUCTIONS
▸ Select the single best answer for each biology question.
▸ Topics include cell biology, genetics, metabolism, and plant biology.
▸ Focus on understanding key concepts and processes.
▸ Correct answers and rationales appear below each question.
▸ This comprehensive review covers all HESI A2 biology content.
, SECTION I — BIOLOGY: CELLS, GENETICS, METABOLISM
Questions 1 – 369
& MORE
1. How many chromosomes do sperm and egg produce in meiosis?
A. 23
B. 46
C. 92
D. 12
CORRECT ANSWER A — 23
RATIONALE Meiosis produces gametes (sperm and egg) with half the number of
chromosomes, resulting in 23 chromosomes in humans. This haploid number
ensures that fertilization restores the diploid number of 46 chromosomes.
2. How many chromosomes do sperm and egg produce in mitosis?
A. 23
B. 46
C. 92
D. 24
CORRECT ANSWER B — 46
RATIONALE Mitosis produces daughter cells with the same number of chromosomes as the
parent cell. In humans, this means 46 chromosomes (23 pairs) in each daughter
cell.
,3. What helps the cell shape and cell to adapt?
A. Cytoskeleton
B. Nucleus
C. Mitochondria
D. Ribosomes
CORRECT ANSWER A — Cytoskeleton
RATIONALE The cytoskeleton is a network of protein filaments that helps maintain cell shape,
provides mechanical support, and enables cell movement and adaptation to
environmental changes.
4. What gives the cell the ability to move and proper?
A. Microtubules
B. Ribosomes
C. Lysosomes
D. Vacuoles
CORRECT ANSWER A — Microtubules
RATIONALE Microtubules are components of the cytoskeleton that provide structural support,
facilitate intracellular transport, and enable cell movement through structures
like cilia and flagella.
5. What is the main component of blood plasma?
A. Water
B. Proteins
C. Lipids
D. Carbohydrates
CORRECT ANSWER A — Water
RATIONALE Blood plasma is approximately 90-92% water, with the remainder consisting of
dissolved proteins, electrolytes, nutrients, and waste products. Water is the main
component that allows plasma to transport substances throughout the body.
, 6. What is the first step in metabolism of food to cellular energy?
A. Glycolysis
B. Krebs cycle
C. Electron transport chain
D. Fermentation
CORRECT ANSWER A — Glycolysis
RATIONALE Glycolysis is the first step in the metabolism of food to cellular energy. It occurs in
the cytosol and converts glucose into pyruvate, producing ATP and NADH.
7. What drives the cell / pushes it forward?
A. Propulsion
B. Diffusion
C. Osmosis
D. Active transport
CORRECT ANSWER A — Propulsion
RATIONALE Propulsion refers to the ability of cells to move or be moved forward. In cells, this
can be achieved through structures like flagella and cilia, which provide motility.
8. All humans have how many pairs of chromosomes?
A. 23 pairs
B. 22 pairs
C. 24 pairs
D. 46 pairs
CORRECT ANSWER A — 23 pairs
RATIONALE Humans have 23 pairs of chromosomes (22 pairs of autosomes and 1 pair of sex
chromosomes), for a total of 46 chromosomes. Each pair consists of one
chromosome from each parent.
