Pharmacology Complete Study MCQ and answers Bank

PHARMACOLOGY
MCQ PRACTICE BANK
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200 Questions with 4 Options (A-D)
Complete Answer Key Included




200 QUESTIONS • 4 OPTIONS EACH • ANSWER KEY


Instructions: Read each question carefully and select the best answer.
Use active recall before checking the answer key at the end.

,PRACTICE QUESTIONS
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Q1. The volume of distribution (Vd) of a drug is calculated by:
A. Dose / Plasma concentration
B. Plasma concentration / Dose
C. Dose × Plasma concentration
D. Clearance / Half-life

Q2. Which of the following drugs exhibits zero-order kinetics at therapeutic doses?
A. Penicillin G
B. Phenytoin
C. Amoxicillin
D. Metformin

Q3. The therapeutic index (TI) of a drug is defined as:
A. ED50 / TD50
B. TD50 / ED50
C. LD50 / ED50
D. ED50 / LD50

Q4. Bioavailability of an intravenously administered drug is:
A. 50%
B. 75%
C. 90%
D. 100%

Q5. Which enzyme is inhibited by cimetidine?
A. CYP1A2
B. CYP2D6
C. CYP3A4
D. All of the above

Q6. Rifampicin is a potent inducer of which cytochrome P450 enzyme?
A. CYP2C9
B. CYP2D6
C. CYP3A4
D. CYP1A2

Q7. A drug with high therapeutic index is:
A. More toxic
B. Safer
C. Less effective
D. More addictive

Q8. First-pass metabolism occurs primarily in the:
A. Kidneys

, B. Liver
C. Lungs
D. Intestines

Q9. The loading dose of a drug depends on:
A. Clearance and half-life
B. Volume of distribution and target concentration
C. Renal function only
D. Hepatic function only

Q10. Which of the following is an example of pharmacodynamic drug interaction?
A. Warfarin + Rifampicin
B. Aspirin + Warfarin
C. Phenytoin + Cimetidine
D. Theophylline + Erythromycin



Q11. Steady-state concentration is reached after approximately:
A. 1 half-life
B. 3 half-lives
C. 5 half-lives
D. 10 half-lives

Q12. A partial agonist:
A. Has no intrinsic activity
B. Produces submaximal response
C. Blocks receptor completely
D. Has higher affinity than full agonist

Q13. The clearance of a drug is defined as:
A. Rate of elimination / Plasma concentration
B. Plasma concentration / Rate of elimination
C. Dose / AUC
D. AUC / Dose

Q14. Which drug is known to cause enzyme induction?
A. Ketoconazole
B. Erythromycin
C. Carbamazepine
D. Ciprofloxacin

Q15. Grapefruit juice inhibits which CYP enzyme?
A. CYP2D6
B. CYP3A4
C. CYP1A2
D. CYP2C19

Q16. The half-life of a drug is inversely proportional to:
A. Volume of distribution
B. Clearance
C. Bioavailability

, D. Protein binding

Q17. An inverse agonist:
A. Produces opposite effect to agonist
B. Blocks receptor without effect
C. Has no affinity for receptor
D. Enhances agonist effect

Q18. Which factor does NOT affect drug absorption?
A. Lipid solubility
B. Molecular weight
C. Drug color
D. pH of environment

Q19. Competitive antagonism can be overcome by:
A. Decreasing agonist concentration
B. Increasing agonist concentration
C. Adding another antagonist
D. Changing the receptor

Q20. The area under the curve (AUC) represents:
A. Peak drug concentration
B. Total drug exposure over time
C. Time to peak concentration
D. Drug elimination rate



Q21. Atropine acts as a:
A. Muscarinic agonist
B. Muscarinic antagonist
C. Nicotinic agonist
D. Nicotinic antagonist

Q22. Neostigmine is used in the treatment of:
A. Glaucoma
B. Myasthenia gravis
C. Asthma
D. Hypertension

Q23. The antidote for organophosphate poisoning is:
A. Naloxone
B. Atropine + Pralidoxime
C. Flumazenil
D. N-acetylcysteine

Q24. Pilocarpine is used in:
A. Hypertension
B. Glaucoma
C. Asthma
D. Arrhythmias