Week 3 Exam: NR565 / NR 565
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Major Psychoactive Substance in Cannabis Sativa
Answer:
· The psychoactive compound is called delta-9-tetrahydrocannabinol (THC).
THC is highly lipid soluble and acts on cannabinoid receptors in the brain to
cause various effects impacting pleasure, memory, appetite, and
coordination
· Oral forms undergo heavy first-pass metabolism, requiring much higher
oral dosing to reach therapeutic effects.
,Question:
Smoking vs. Oral Administration of Marijuana
Answer:
· THC competitively inhibits certain CYP enzymes in the liver involved in
drug metabolism, including CYP1A2, CYP2B6, CYP2C9, and CYP2D6,
although there are a lack of clinical trials demonstrating the likelihood of
interactions.
oral ingestion goes through intense first pass effect, leaving only 6-20%
absorbed. Oral dose must be 3-10 times greater and response begins in
30-50 minutes and persists to 12 hours.
Smoking: 60% of THC is absorbed. Lung absorption is rapid and begins in
10 to 20 minutes and can last for 2-3 hours
, Question:
Naloxone Administration for Opioid Overdose
Answer:
· Drug of choice for treatment of opioid overdose.
o OD produced in triad of symptoms: respiratory depression, coma,
pinpoint pupils
· Rapidly reverses all signs of opioid poisoning
· Can cause swing from intoxication to withdrawal
· Must be readministered every few hours due to short half life
· Can be administered with
o nasal spray 4-8mg to one nostril. If no response, may be given every 2-3
minutes
o prefilled syringe (Zimhi) for IM in thigh. Readmin q 2-3 min if needed
Question:
Tolerance Development to Opioids
Answer:
· Occurs with prolonged opioid use. Pharmacological tolerance occurs with
some opioid effects and not others
· Pts grow tolerant of: euphoria, respiratory depression, nausea
No tolerance to constipation or miosis
· Cross tolerance to other opioids can occur
· No cross tolerance with other CNS depressants such as alcohol, benzos,
barbiturates
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Major Psychoactive Substance in Cannabis Sativa
Answer:
· The psychoactive compound is called delta-9-tetrahydrocannabinol (THC).
THC is highly lipid soluble and acts on cannabinoid receptors in the brain to
cause various effects impacting pleasure, memory, appetite, and
coordination
· Oral forms undergo heavy first-pass metabolism, requiring much higher
oral dosing to reach therapeutic effects.
,Question:
Smoking vs. Oral Administration of Marijuana
Answer:
· THC competitively inhibits certain CYP enzymes in the liver involved in
drug metabolism, including CYP1A2, CYP2B6, CYP2C9, and CYP2D6,
although there are a lack of clinical trials demonstrating the likelihood of
interactions.
oral ingestion goes through intense first pass effect, leaving only 6-20%
absorbed. Oral dose must be 3-10 times greater and response begins in
30-50 minutes and persists to 12 hours.
Smoking: 60% of THC is absorbed. Lung absorption is rapid and begins in
10 to 20 minutes and can last for 2-3 hours
, Question:
Naloxone Administration for Opioid Overdose
Answer:
· Drug of choice for treatment of opioid overdose.
o OD produced in triad of symptoms: respiratory depression, coma,
pinpoint pupils
· Rapidly reverses all signs of opioid poisoning
· Can cause swing from intoxication to withdrawal
· Must be readministered every few hours due to short half life
· Can be administered with
o nasal spray 4-8mg to one nostril. If no response, may be given every 2-3
minutes
o prefilled syringe (Zimhi) for IM in thigh. Readmin q 2-3 min if needed
Question:
Tolerance Development to Opioids
Answer:
· Occurs with prolonged opioid use. Pharmacological tolerance occurs with
some opioid effects and not others
· Pts grow tolerant of: euphoria, respiratory depression, nausea
No tolerance to constipation or miosis
· Cross tolerance to other opioids can occur
· No cross tolerance with other CNS depressants such as alcohol, benzos,
barbiturates
