Wgu D116 Pharmacology Study Guide: Key Concepts and Drug Interactions Latest Update with complete solutions.

Grapefruit juice inhibits CYP3A4, which lowers the metabolism of some drugs, leading to toxic effects of drugs affected by these isoenzymes. Some foods can inhibit CYP isoenzymes and alter drug metabolism. With respect to the cytochrome P450 (CYP) system, what will result in a higher concentration of a drug? Inhibition of the enzyme (Decreasing enzyme activity leads to decreased metabolism of the drug.) The therapeutic index is calculated by dividing the median toxic dose by the median efficacious dose. antibiotics can interact with warfarin and his PT/INR needs to be checked more often. Morphine is a medication that is selective to receptor types that regulate more than one process. Hence –Constipation Schedule IV substance and all scheduled substances require the prescriber to be registered with the DEA. A special waiver (DATA 2000) is required in addition to your DEA registration in order to prescribe Schedule II and Schedule III controlled substances for addiction. Macrolide antibiotics are inhibitors of the cytochrome system. Therapeutic drug monitoring promotes an individualized drug plan based on serum levels of drug and patient outcomes. Digoxin is a narrow therapeutic window index drug that requires levels to be drawn frequently to assess for efficacy and toxicity. A patient receives a drug that has a narrow therapeutic range. The NP administering this medication will expect to do what? MONITOR PLASMA DRUG LEVELS -- To ensure safety, measurement of serum drug levels is necessary with medications that have a narrow therapeutic range. A patient prescribed amoxicillin for streptococcal pharyngitis reports new onset of a flat, itchy red rash on the chest and neck. Which action is most important?—DISCONTINUE the medication A patient is receiving intravenous gentamicin. A serum drug test reveals toxic levels. The dosing is correct, and this medication has been tolerated by this patient in the past. Which could be a probable cause of the test result---When a patient is taking two drugs that bind to the same receptor, the response of one or both of the medications can be