NBME PATHOLOGY EXAM NEWEST 2026 ACTUAL
EXAM TEST BANK| 2 LATEST VERSIONS (VERSION A &
B) WITH 550 REAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) ALREADY
GRADED A+| PATHOLOGY NBME FINAL EXAM
PREP|| BRAND NEW
Question 1
A 60-year-old man with a history of alcohol use disorder
presents with ascites and jaundice. Liver biopsy shows
hepatocytes with irregular, pink cytoplasmic inclusions. These
inclusions are most likely composed of:
A. Glycogen
B. Lipid
C. Mallory bodies (intermediate filaments)
D. Alpha-1 antitrypsin globules
1
,Answer: C
Rationale: Mallory bodies (hyaline inclusions) are seen in alcoholic
liver disease and consist of aggregated intermediate filaments
(cytokeratins). They appear as irregular, eosinophilic cytoplasmic
inclusions.
Question 2
A 45-year-old woman undergoes a breast biopsy. Microscopy
shows a pink, amorphous material within blood vessel walls. This
material stains positive with Congo red and shows apple-green
birefringence under polarized light. The substance is:
A. Hyaline
B. Amyloid
C. Fibrin
D. Collagen
2
,Answer: B
Rationale: Apple-green birefringence with Congo red is diagnostic
of amyloid. Amyloid deposition in vessel walls causes vascular
fragility.
Question 3
A patient with chronic ischemia of the lower extremity has
atrophy of skeletal muscle cells. Which of the following best
describes the microscopic appearance of these cells?
A. Increased cell size with enlarged nuclei
B. Decreased cell size with normal nuclei
C. Nuclear pyknosis and karyorrhexis
D. Lipid vacuoles within cytoplasm
Answer: B
Rationale: Atrophy is a decrease in cell size and organ size due to
3
, decreased workload, denervation, or ischemia. Cells shrink but
remain viable.
Question 4
A pathologist examines a section of myocardium after a
myocardial infarction. Within the center of the infarct, neutrophils
are abundant. This tissue is in which stage of healing?
A. Acute inflammation (24-72 hours)
B. Organization (5-10 days)
C. Scar formation (weeks)
D. Resolution (hours)
Answer: A
*Rationale: Neutrophils peak at 24-72 hours after infarction.
Macrophages replace neutrophils by day 3-7. Organization
begins after 5-10 days.*
4
EXAM TEST BANK| 2 LATEST VERSIONS (VERSION A &
B) WITH 550 REAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) ALREADY
GRADED A+| PATHOLOGY NBME FINAL EXAM
PREP|| BRAND NEW
Question 1
A 60-year-old man with a history of alcohol use disorder
presents with ascites and jaundice. Liver biopsy shows
hepatocytes with irregular, pink cytoplasmic inclusions. These
inclusions are most likely composed of:
A. Glycogen
B. Lipid
C. Mallory bodies (intermediate filaments)
D. Alpha-1 antitrypsin globules
1
,Answer: C
Rationale: Mallory bodies (hyaline inclusions) are seen in alcoholic
liver disease and consist of aggregated intermediate filaments
(cytokeratins). They appear as irregular, eosinophilic cytoplasmic
inclusions.
Question 2
A 45-year-old woman undergoes a breast biopsy. Microscopy
shows a pink, amorphous material within blood vessel walls. This
material stains positive with Congo red and shows apple-green
birefringence under polarized light. The substance is:
A. Hyaline
B. Amyloid
C. Fibrin
D. Collagen
2
,Answer: B
Rationale: Apple-green birefringence with Congo red is diagnostic
of amyloid. Amyloid deposition in vessel walls causes vascular
fragility.
Question 3
A patient with chronic ischemia of the lower extremity has
atrophy of skeletal muscle cells. Which of the following best
describes the microscopic appearance of these cells?
A. Increased cell size with enlarged nuclei
B. Decreased cell size with normal nuclei
C. Nuclear pyknosis and karyorrhexis
D. Lipid vacuoles within cytoplasm
Answer: B
Rationale: Atrophy is a decrease in cell size and organ size due to
3
, decreased workload, denervation, or ischemia. Cells shrink but
remain viable.
Question 4
A pathologist examines a section of myocardium after a
myocardial infarction. Within the center of the infarct, neutrophils
are abundant. This tissue is in which stage of healing?
A. Acute inflammation (24-72 hours)
B. Organization (5-10 days)
C. Scar formation (weeks)
D. Resolution (hours)
Answer: A
*Rationale: Neutrophils peak at 24-72 hours after infarction.
Macrophages replace neutrophils by day 3-7. Organization
begins after 5-10 days.*
4
