Blood Banking
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Chemistry (ASCP MLT BOARD EXAM... Hematology: Understanding Hemat... Sickle Cell Disease Leukem
343 terms 5 terms 10 terms 59 terms
jennymathew Preview oliviagb1656 Preview hanrtaylor Preview P vala
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Donor Qualification 16yo or older with consent, no recent travel to places that have high incidence of
malaria, > 110lbs, photo ID, 90-180/50-100BP, 99.5F temp, not pregnant
Donor Collection methods 1. Whole Blood Donation
2. Apheresis: Machine that collects only the target component and the rest goes
back into the donor
Adverse rxns to blood donation brusing, feeling faint, low blood glucose, nausea
Special Donations -autologous
-directed
Autologous Donations -in good health, >110 pounds, donate 4-7 days before surgery, HGB adequate
Directed Donations ABO/RH compatible family or friend donate their blood. Tested for HIV, other
infectious disease
,Lab Testing of Blood Products Units received from Blood Bank (Vitaent) to lab. Lab receives them in LIS. Lab
retypes for ABO/RH.
Blood Component Labels -Donor ID #: W
-Product Code: E
Red Blood Cells 42 days 1-6C
Carry oxygen from our lungs to the rest of the bodies and take CO2 back into
lungs to be exhales
-Prepared from Whole Blood by removing plasma
-Can be treated with anticogaulant and frozen for 10 years or more
-Use: Trauma: acute blood loss, anemia (w/o increase blood vol) from kidney
failure or GI bleed, sickle cell anemia
Leukocyte-reduced RBCs LR RBC are prepared by removing lekuocytes (WBCs) by filtration shortly after
donation. Due to over time WBCs in Red cells can fragment and deteriorate and
release cytokines which trigger negative rxns in a patient
-WBCs can create antibodies so to avoid these reactions leukocytes are removed
Cryoprecipitate (CAF) Rich in FVIII (8) and Fibrinogen
-1 year frozen -60C
-Reduce blood loss by helping slow/stop bleeding
-Cryo is made by freezing and then slowly thawing frozen plasma. The PPT is
colelcted and pooled with other donors to reach adequate volumes for donations
-Uses: Hemophilia, Von Willebrand disease
Platelets Platelets stick to the lining of blood vessels and help stop bleeding, made in our
bone marrow.
-Formed from cytoplasmic fragments of megakaryocytes, and stored in spleen
-Store and transport chemicals: serotonin, epinephrine, histamine, thromboxane
which can activate and release local blood vessel constriction which facilitates
clot formation
-Platelets can increase following trauma, asphyxiation, high altitudes, exercise,
cold temps
-Platelets lower: menstruation
-5 days RT 24C with platelet agitator to prevent clumping
-Uses: Cancer treatments, organ transplant, surgery to treat thrombocytopenia, or
platelet fxn abnormalities
-Prepared: Centrifuge Platelet rich plasma from whole blood. Platelets are
combined from different donors to create 1 unit
-Other prep: Apheresis machine: separation machine during donation process:
Donor can contribute 4-6x as many platelets obtained from WB donation
, Plasma Liquid portion of blood; RBCs, and WBcs, PLTs are suspended in plasma as it
moves through the body
-Frozen for up to 1 year -60C
-Contains proteins: albumin, gamma globulin, anti-hemophilic factor, 1% mineral,
salts, sugars, fats hormones, and vitamins
-Use: Maintains satisfactory BP and volume, supplies proteins for clotting,
electrolytes Na, K to muscles and maintains pH for cell fxn, Trauma, burn/shock
patient, severe liver disease, or mutliple clotting factor deficiencies
-Prepared: Seperating liquid portion of blood from the cells. Plasma is frozen
within 24 hrs of being donated in order to preserve clotting factors and then
stored for 1 year
Plasma Derivatives Concentrates of specific plasma proteins obtained through process known s
fractionation. Derivatives are treated with heat or solvent/detergent to kill viruses:
HIV,HepB, HepC
Ex of Plasma derivatives: FViii, FIX, Anti-inhibitor Coagulation complex AICC,
Albumin, Immune globulins, Anti-thrombin III, Alpha 1 Proteinase Inhibitor
Granulocytes Type of WBC that protects against infection by surrounding and destroying
invading bacteria and viruses. Used to treat infection that don't respond to
antibiotics
-Prepared: collected by apheresis and must be transfused into patient within
24hrs of donation
-Donation is taken on an as-needed basis
Thawed/Deglycerolized RBCs Thawed, previously frozen RBC products processed to remove glycerol prior to
transfusion.
-Glycerol protects RBCs during freezing and thawing and cause hemolysis if not
removed (washed out) before transfusion.
-Exp: after deglycerized expires 24 hrs from start of procedure (open) or 14 days
in closed system
-lowers risk of allergic, nonfebrile transfusion reactions
Apheresis Selective removal of a targeted portion of blood and return non-targeted
portions to the individual.
-removal of WB from donor and separation through machine
Anti-coagulant used in Whole Blood Products CPD, CP2D, ACD: Citrate phosphate dextrose; 21 days expiration
CPDA-1 (Citrate-Phosphate-Dextrose-Adenine): Contains adenine to improve red
blood cell viability, extending storage to 35 days.
Fractionated Plasma Products Targets specific factor deficiencies: Albumin, Coag Factors, Fibrin, etc, Protein C,
IgG, etc
Whole Blood Contains RBCs, WBCs, PLTs=45%, suspended in plasma = 55%
-Exp: 21/35 days 1-6C depends on anticoagulant used
-used to treat patients who need all components of blood: Trauma, or surgery
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Flashcard sets Study guides
Chemistry (ASCP MLT BOARD EXAM... Hematology: Understanding Hemat... Sickle Cell Disease Leukem
343 terms 5 terms 10 terms 59 terms
jennymathew Preview oliviagb1656 Preview hanrtaylor Preview P vala
Terms in this set (287) Hide definitions
Donor Qualification 16yo or older with consent, no recent travel to places that have high incidence of
malaria, > 110lbs, photo ID, 90-180/50-100BP, 99.5F temp, not pregnant
Donor Collection methods 1. Whole Blood Donation
2. Apheresis: Machine that collects only the target component and the rest goes
back into the donor
Adverse rxns to blood donation brusing, feeling faint, low blood glucose, nausea
Special Donations -autologous
-directed
Autologous Donations -in good health, >110 pounds, donate 4-7 days before surgery, HGB adequate
Directed Donations ABO/RH compatible family or friend donate their blood. Tested for HIV, other
infectious disease
,Lab Testing of Blood Products Units received from Blood Bank (Vitaent) to lab. Lab receives them in LIS. Lab
retypes for ABO/RH.
Blood Component Labels -Donor ID #: W
-Product Code: E
Red Blood Cells 42 days 1-6C
Carry oxygen from our lungs to the rest of the bodies and take CO2 back into
lungs to be exhales
-Prepared from Whole Blood by removing plasma
-Can be treated with anticogaulant and frozen for 10 years or more
-Use: Trauma: acute blood loss, anemia (w/o increase blood vol) from kidney
failure or GI bleed, sickle cell anemia
Leukocyte-reduced RBCs LR RBC are prepared by removing lekuocytes (WBCs) by filtration shortly after
donation. Due to over time WBCs in Red cells can fragment and deteriorate and
release cytokines which trigger negative rxns in a patient
-WBCs can create antibodies so to avoid these reactions leukocytes are removed
Cryoprecipitate (CAF) Rich in FVIII (8) and Fibrinogen
-1 year frozen -60C
-Reduce blood loss by helping slow/stop bleeding
-Cryo is made by freezing and then slowly thawing frozen plasma. The PPT is
colelcted and pooled with other donors to reach adequate volumes for donations
-Uses: Hemophilia, Von Willebrand disease
Platelets Platelets stick to the lining of blood vessels and help stop bleeding, made in our
bone marrow.
-Formed from cytoplasmic fragments of megakaryocytes, and stored in spleen
-Store and transport chemicals: serotonin, epinephrine, histamine, thromboxane
which can activate and release local blood vessel constriction which facilitates
clot formation
-Platelets can increase following trauma, asphyxiation, high altitudes, exercise,
cold temps
-Platelets lower: menstruation
-5 days RT 24C with platelet agitator to prevent clumping
-Uses: Cancer treatments, organ transplant, surgery to treat thrombocytopenia, or
platelet fxn abnormalities
-Prepared: Centrifuge Platelet rich plasma from whole blood. Platelets are
combined from different donors to create 1 unit
-Other prep: Apheresis machine: separation machine during donation process:
Donor can contribute 4-6x as many platelets obtained from WB donation
, Plasma Liquid portion of blood; RBCs, and WBcs, PLTs are suspended in plasma as it
moves through the body
-Frozen for up to 1 year -60C
-Contains proteins: albumin, gamma globulin, anti-hemophilic factor, 1% mineral,
salts, sugars, fats hormones, and vitamins
-Use: Maintains satisfactory BP and volume, supplies proteins for clotting,
electrolytes Na, K to muscles and maintains pH for cell fxn, Trauma, burn/shock
patient, severe liver disease, or mutliple clotting factor deficiencies
-Prepared: Seperating liquid portion of blood from the cells. Plasma is frozen
within 24 hrs of being donated in order to preserve clotting factors and then
stored for 1 year
Plasma Derivatives Concentrates of specific plasma proteins obtained through process known s
fractionation. Derivatives are treated with heat or solvent/detergent to kill viruses:
HIV,HepB, HepC
Ex of Plasma derivatives: FViii, FIX, Anti-inhibitor Coagulation complex AICC,
Albumin, Immune globulins, Anti-thrombin III, Alpha 1 Proteinase Inhibitor
Granulocytes Type of WBC that protects against infection by surrounding and destroying
invading bacteria and viruses. Used to treat infection that don't respond to
antibiotics
-Prepared: collected by apheresis and must be transfused into patient within
24hrs of donation
-Donation is taken on an as-needed basis
Thawed/Deglycerolized RBCs Thawed, previously frozen RBC products processed to remove glycerol prior to
transfusion.
-Glycerol protects RBCs during freezing and thawing and cause hemolysis if not
removed (washed out) before transfusion.
-Exp: after deglycerized expires 24 hrs from start of procedure (open) or 14 days
in closed system
-lowers risk of allergic, nonfebrile transfusion reactions
Apheresis Selective removal of a targeted portion of blood and return non-targeted
portions to the individual.
-removal of WB from donor and separation through machine
Anti-coagulant used in Whole Blood Products CPD, CP2D, ACD: Citrate phosphate dextrose; 21 days expiration
CPDA-1 (Citrate-Phosphate-Dextrose-Adenine): Contains adenine to improve red
blood cell viability, extending storage to 35 days.
Fractionated Plasma Products Targets specific factor deficiencies: Albumin, Coag Factors, Fibrin, etc, Protein C,
IgG, etc
Whole Blood Contains RBCs, WBCs, PLTs=45%, suspended in plasma = 55%
-Exp: 21/35 days 1-6C depends on anticoagulant used
-used to treat patients who need all components of blood: Trauma, or surgery
