NURS 320 Exam 1
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NURS 320 Exam 1
differentiate between generic name and brand name medications
brand names more expensive
brand names have more iconic packaging
generic names are bioequivalent
10 rights of medication administration
patient
dose
route
time
medication
documentation
refusal
assessment
education
evaluation
why do certain medications have to be prescribed?
identified by government to be potential harmful without professional supervision
advantage and disadvantage of oral administration?
A: convenient
D: variable absorption
advantage and disadvantage of IV administration?
A: rapid
D: infection risks
advantage and disadvantage of subq administration?
A: slow, steady absorption
D. limited volume
advantage and disadvantage of IM administration?
A: moderate absorption
D: pain potential
advantage and disadvantage of topical administration?
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A: localized
D: skin-limited
advantage and disadvantage of transdermal administration?
A: prolonged systemic effect
D: works with only certain meds
advantage and disadvantage of inhalation administration?
A: direct delivery to respiratory system
D: limitations of resp. meds
advantage and disadvantage of rectal administration?
A: bypass first-pass, when oral is not preferred
D: tolerance, variable absorption
pharmacokinetics vs pharmacodynamics
kinetics - body's effects on drug
dynamics - drug's effects on body
4 concepts of pharmacokinetics
absorption
distribution
metabolism (biotransformation)
excretion
absorption
entering bloodsteam
factors impacting absorption rate
amount: intensity of effects
route:
distribution
traveling of meds to sites of action
factors influencing distribution
circulation
tissue permeability
plasma protein binding: proteins can bind to drugs for extended effects while free
drugs perfuse through membrane
metabolism
meds changing into inactive forms
factorings influencing metabolism
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age
metabolizing enzyme activity/amount
first-pass effect
nutritional status
similar metabolic pathways (for medications)
excretion
mainly kidneys eliminating meds
other sites: liver, lungs, intestines, exocrine glands
factors influencing excretion
kidney function (BUN/creatinine): increased values = less filtering
GFR
half life of medication
time required for
concentration to decrease by
half
can predict duration and dosing intervals
bioavailability
amount of drug reaching circulation unchanged
IV = 100%
factors influencing bioavailability
absorption
first pass
drug formulation
onset
peak
duration
O: initial therapeutic effect
P: full therapeutic effect
D: how long a single dose's therapeutic effects last
peak level
trough level