Karch’s Focus on Nursing
Pharmacology
9th Edition
Author(s)Rebecca G. Tucker
TEST BANK
Question 1
Clinical Scenario
,A nursing student asks why a newly discovered plant compound
cannot be prescribed immediately after researchers identify
potential therapeutic effects.
Question
Which explanation by the nurse educator is most accurate?
Options
A. The drug must first complete preclinical testing before
human studies begin.
B. The drug can be marketed immediately if it is derived from a
natural source.
C. The drug must first be approved by pharmacists before
testing.
D. The drug can be prescribed once laboratory testing confirms
effectiveness.
Correct Answer
A. The drug must first complete preclinical testing before
human studies begin.
Rationale
,Preclinical testing evaluates a drug's safety, toxicity,
pharmacologic activity, and potential therapeutic effects using
laboratory and animal studies before human exposure occurs.
This process helps identify significant risks before clinical trials
begin.
Why the Other Options Are Incorrect
B. Natural origin does not exempt a drug from safety and
efficacy testing.
C. Pharmacists do not authorize progression into clinical trials.
D. Laboratory effectiveness alone is insufficient; human safety
and efficacy studies are required.
Learning Objective
Explain the purpose of preclinical drug testing.
Bloom's Taxonomy: Understand
Difficulty: Easy
NCLEX Client Needs Category: Pharmacological and Parenteral
Therapies
NCJMM Clinical Judgment Skill: Recognize Cues
, Question 2
Clinical Scenario
A healthy volunteer enrolls in a clinical drug study designed
primarily to determine the medication's safety profile and
dosage range.
Question
Which phase of clinical testing is being conducted?
Options
A. Preclinical testing
B. Phase I study
C. Phase III study
D. Phase IV study
Correct Answer
B. Phase I study
Rationale
Phase I studies involve a small number of healthy volunteers
and focus on safety, dosage determination, pharmacokinetics,
and adverse effects.
Pharmacology
9th Edition
Author(s)Rebecca G. Tucker
TEST BANK
Question 1
Clinical Scenario
,A nursing student asks why a newly discovered plant compound
cannot be prescribed immediately after researchers identify
potential therapeutic effects.
Question
Which explanation by the nurse educator is most accurate?
Options
A. The drug must first complete preclinical testing before
human studies begin.
B. The drug can be marketed immediately if it is derived from a
natural source.
C. The drug must first be approved by pharmacists before
testing.
D. The drug can be prescribed once laboratory testing confirms
effectiveness.
Correct Answer
A. The drug must first complete preclinical testing before
human studies begin.
Rationale
,Preclinical testing evaluates a drug's safety, toxicity,
pharmacologic activity, and potential therapeutic effects using
laboratory and animal studies before human exposure occurs.
This process helps identify significant risks before clinical trials
begin.
Why the Other Options Are Incorrect
B. Natural origin does not exempt a drug from safety and
efficacy testing.
C. Pharmacists do not authorize progression into clinical trials.
D. Laboratory effectiveness alone is insufficient; human safety
and efficacy studies are required.
Learning Objective
Explain the purpose of preclinical drug testing.
Bloom's Taxonomy: Understand
Difficulty: Easy
NCLEX Client Needs Category: Pharmacological and Parenteral
Therapies
NCJMM Clinical Judgment Skill: Recognize Cues
, Question 2
Clinical Scenario
A healthy volunteer enrolls in a clinical drug study designed
primarily to determine the medication's safety profile and
dosage range.
Question
Which phase of clinical testing is being conducted?
Options
A. Preclinical testing
B. Phase I study
C. Phase III study
D. Phase IV study
Correct Answer
B. Phase I study
Rationale
Phase I studies involve a small number of healthy volunteers
and focus on safety, dosage determination, pharmacokinetics,
and adverse effects.
