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Mean arterial pressure
- lies somewhere between systolic and diastolic pressure
- influenced more by diastolic pressure than by systolic
pressure because the heart spends more time in diastole
than in systole
- rises to meet the bodies' metabolic demand during
periods of exertion.
- BP value of greatest clinical significance
Resting MAP
- represents the force required to adequately perfuse the bodies'
tissues at rest
,Systolic, mean arterial pressure, diastolic
Identify (top to bottom)
Formula for mean arterial pressure
MAP = diastolic pressure + 1/3(pulse pressure)
Alternative formula for MAP
MAP = cardiac output X total peripheral resistance
Blood pressure
- expressed as systolic/diastolic
- normal in a healthy, young adult is 120/80 mm Hg
Tissue perfusion
- the volume of blood that flows through arteries and capillaries
to target tissues
,Arterial blood pressure
- determined by cardiac output and systemic vascular resistance
No perfusion
- infarction
- tissue dies because there is no blood flow or nutrients
Scope of perfusion
- ranges from optimal to impaired to no perfusion
- changes can be temporary, long term or permanent
- disorders that lead to changes can be acute or chronic
- conditions involving perfusion can be neurologic,
pulmonary and cardiovascular
- caused by congenital defects, genetic disorders, injury,
inflammation, and infections
Examples of acute conditions
- myocardial infarction
- stroke
- shock
, Examples of chronic conditions
- hypertension
- heart failure
- sickle cell
- hemophilia
Optimal perfusion
- optimal blood flow and oxygen delivery to meet tissue demands
- not necessarily constant perfusion (it matches the need
of the particular tissue - e.g., low at rest and high during
exercise)
Impaired perfusion
- "ischemia" - reduction in blood flow
- cell/tissue injury
- occurs in conditions that decrease cardiac output or cause shock
- associated with the occlusion, construction, or rupture of
blood vessels
- any impairment in central perfusion will interfere with tissue
perfusion
- often temporary, but there are cases where it gets progressively
worse