NR668 Week 4 Psychopharmacology
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Pharmacodynamics - correct ans:How the drug effects the body
,-therapeutic vs. side effects
• Is it stimulating?
• Is it depressing?
• Does it block something?
-Onset of action
• Route, Dosage
-Duration of action
• Redistribution rate, metabolism rate and excretion rate
-Mechanism of action
• Drugs simply speed up or slow down what is already occurring in the body
-Efficacy
• (Intrinsic activity) After binding, the drugs capacity to cause an effect
-Potency
• The amount of a drug needed to produce a given effect
efficacy examples - correct ans:-Agonist (Efficacy = 100)
-Partial Agonist (Efficacy = > 0 < 100)
-Antagonist (Efficacy = 0.0)
-Inverse Agonist (Efficacy = < 0)
Agonist: - correct ans:Compounds which give maximal response after receptor occupation and
activation.
-Example: Oxycodone
Partial Agonists: - correct ans:Compounds which activate the receptor but not at the maximal response.
-Example Buprenorphine (Suboxone) or Buspirone
Antagonist: - correct ans:Blocks the action of an agonist.
-Example: Neuroleptics, Naloxone
, Inverse Agonist: - correct ans:Binds to receptor and has the opposite action of an agonist and below
baselinesignal transduction
Pharmacokinetics - correct ans:How the body effects the drug
-Absorption, distribution, metabolism and elimination (ADME)
-Metabolizing the drug via CYP450 through the gut & liver
Bioavailability - correct ans:Absorption: Drugs cross a barrier.
-Involves bioavailability or Quantity of drug reaching circulation/quantityof the drug administered.
• Our own barriers such as skin and mucous membranes as well as food, molecular weight, chemical,
biological barriers, etc. reduce how much drug is actually absorbed and available. IV route has 100%
bioavailability. All other routes <100%
First pass metabolism - correct ans:-reduces the concentration of a drug
• travels through digestive system & entering the liver.
• reducing the bioavailability of the drug
rate is reduced by: - correct ans:-Route (IV, PO, Rectum, etc.)
-Dosage (Concentration)
-Lipid Solubility
Drugs that cross the BBB are _____________ - correct ans:fat soluble
Vd: Volume of distribution = ________ - correct ans:amount of drug/concentration
• large Volume of distribution may indicate the drug distributes extensively into the body
• Vd is a theoretical fluid volume necessary to contain the total amount of a drug at the same
concentration observed in the plasma
Latest Verified And Frequently tested
exam With Expected real Questions
With Well Elaborated Correct Answers
GRADED A+
Professional Academic Assistance Services
Services Offered
Proctored Exam Assistance
Online Class Management (Full Course Support)
Exam Preparation & Study Materials
Assignments and Coursework Support
Essays and Research Papers
Discussion Posts and Replies
Pharmacodynamics - correct ans:How the drug effects the body
,-therapeutic vs. side effects
• Is it stimulating?
• Is it depressing?
• Does it block something?
-Onset of action
• Route, Dosage
-Duration of action
• Redistribution rate, metabolism rate and excretion rate
-Mechanism of action
• Drugs simply speed up or slow down what is already occurring in the body
-Efficacy
• (Intrinsic activity) After binding, the drugs capacity to cause an effect
-Potency
• The amount of a drug needed to produce a given effect
efficacy examples - correct ans:-Agonist (Efficacy = 100)
-Partial Agonist (Efficacy = > 0 < 100)
-Antagonist (Efficacy = 0.0)
-Inverse Agonist (Efficacy = < 0)
Agonist: - correct ans:Compounds which give maximal response after receptor occupation and
activation.
-Example: Oxycodone
Partial Agonists: - correct ans:Compounds which activate the receptor but not at the maximal response.
-Example Buprenorphine (Suboxone) or Buspirone
Antagonist: - correct ans:Blocks the action of an agonist.
-Example: Neuroleptics, Naloxone
, Inverse Agonist: - correct ans:Binds to receptor and has the opposite action of an agonist and below
baselinesignal transduction
Pharmacokinetics - correct ans:How the body effects the drug
-Absorption, distribution, metabolism and elimination (ADME)
-Metabolizing the drug via CYP450 through the gut & liver
Bioavailability - correct ans:Absorption: Drugs cross a barrier.
-Involves bioavailability or Quantity of drug reaching circulation/quantityof the drug administered.
• Our own barriers such as skin and mucous membranes as well as food, molecular weight, chemical,
biological barriers, etc. reduce how much drug is actually absorbed and available. IV route has 100%
bioavailability. All other routes <100%
First pass metabolism - correct ans:-reduces the concentration of a drug
• travels through digestive system & entering the liver.
• reducing the bioavailability of the drug
rate is reduced by: - correct ans:-Route (IV, PO, Rectum, etc.)
-Dosage (Concentration)
-Lipid Solubility
Drugs that cross the BBB are _____________ - correct ans:fat soluble
Vd: Volume of distribution = ________ - correct ans:amount of drug/concentration
• large Volume of distribution may indicate the drug distributes extensively into the body
• Vd is a theoretical fluid volume necessary to contain the total amount of a drug at the same
concentration observed in the plasma
