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PATHOPHYSIOLOGY I EXAM I
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Johns Hopkins University
School of Nursing
HIGH YIELDS QUESTIONS
NEWEST MODEL 2026 EXAM LATEST
VERSION SOLVED QUESTIONS &
ANSWERS VERIFIED 100 %
Exam
, Page 2 of 66
PATHOPHYSIOLOGY EXAM I
The parents of a 4-year-old girl have sought care because their daughter has
admitted to chewing and swallowing imported toy figurines that have been
determined to be made of lead. Which of the following blood tests should the
care team prioritize?
A. White blood cell levels with differential
B. Red blood cell levels and morphology
C. Urea and creatinine levels
D. Liver function panel
B
Lead -> anemia, RBC lysis
You know it's not A because there is no infection involved. C is focused on kidney
function while D is focused on liver function. Both of these would be important in the
case of lead poisoning BUT the priority answer is B, because you need first to
address the most life-threatening patient needs. The little girl in this question can go
into shock or suffer permanent organ damage if her RBCs are low.
A patient with severe peripheral vascular disease has developed signs of dry
gangrene on the great toe of one foot. Which of the following pathophysiologic
processes most likely contributed to this diagnosis?
A. Inappropriate activation of apoptosis
B. Bacterial invasion
C. Impaired arterial blood supply
D. Metaplastic cellular changes
B
Remember that it's not C because to have gangrene, you must have infection
Although stress exposure initiates integrated responses by multiple systems,
the most important changes are first activated by which system?
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A. Pulmonary
B. Gastrointestinal
C. Neuroendocrine
D. Cardiovascular
C
Which manifestation of stress reflects the non-specific fight or flight
response?
A. Decreased pupillary light response
B. Increased GI motility
C. Decreased short-term memory
D. Increased cardiopulmonary rates
D
This would fall under physiologic responses to stress!! Slide 25 in your lecture
powerpoint
Stress-induced cortisol hormone secretion is associated with:
A. Increased growth hormone level
B. Regulation of the stress response
C. Increased thyroid-stimulating hormone
D. Depressed adrenal gland function
B
You know it's not A because I mentioned in an earlier slide that growth hormone
levels decrease with stress. We didn't mention thyroid-stimulating hormone as one of
the ones associated with the stress repsonse so you can pretty much assume that's
not right. And we know adrenal function is not depressed because ACTH from the
anterior pituitary stimulates the adrenal glands to release cortisol.
Which of the following factors are known to contribute to an individual's ability
to adapt to stress? (Select all that apply.)
, Page 4 of 66
A. Ethnicity
B. Age
C. Socioeconomic status
D. Gender
E. Health status
B, C, D, E
"Ability to adapt to stress" = mediating factors! Slide 28 of this powerpoint
Two people experience the same stressor yet only one is able to cope and
adapt adequately. An example of the person with an increased capacity to
adapt is the one with:
A. A sense of purpose in life
B. Circadian rhythm disruption
C. Age-related renal dysfunction
D. Excessive weight gain or loss
A
Back to mediating factors. Which of these things do you think would help a person
deal with stress? Disruption in sleep cycle (B) will definitely not help, age-related
renal dysfunction (C) is an indicator of poor health status which also would not help,
and excessive weight changes (D) are also likely to cause more stress than alleviate
it
The first circulating immunoglobulin to appear in response to a new antigen is:
A. IgA
B. IgG
C. IgE
D. IgM
PATHOPHYSIOLOGY I EXAM I
Download now
Johns Hopkins University
School of Nursing
HIGH YIELDS QUESTIONS
NEWEST MODEL 2026 EXAM LATEST
VERSION SOLVED QUESTIONS &
ANSWERS VERIFIED 100 %
Exam
, Page 2 of 66
PATHOPHYSIOLOGY EXAM I
The parents of a 4-year-old girl have sought care because their daughter has
admitted to chewing and swallowing imported toy figurines that have been
determined to be made of lead. Which of the following blood tests should the
care team prioritize?
A. White blood cell levels with differential
B. Red blood cell levels and morphology
C. Urea and creatinine levels
D. Liver function panel
B
Lead -> anemia, RBC lysis
You know it's not A because there is no infection involved. C is focused on kidney
function while D is focused on liver function. Both of these would be important in the
case of lead poisoning BUT the priority answer is B, because you need first to
address the most life-threatening patient needs. The little girl in this question can go
into shock or suffer permanent organ damage if her RBCs are low.
A patient with severe peripheral vascular disease has developed signs of dry
gangrene on the great toe of one foot. Which of the following pathophysiologic
processes most likely contributed to this diagnosis?
A. Inappropriate activation of apoptosis
B. Bacterial invasion
C. Impaired arterial blood supply
D. Metaplastic cellular changes
B
Remember that it's not C because to have gangrene, you must have infection
Although stress exposure initiates integrated responses by multiple systems,
the most important changes are first activated by which system?
, Page 3 of 66
A. Pulmonary
B. Gastrointestinal
C. Neuroendocrine
D. Cardiovascular
C
Which manifestation of stress reflects the non-specific fight or flight
response?
A. Decreased pupillary light response
B. Increased GI motility
C. Decreased short-term memory
D. Increased cardiopulmonary rates
D
This would fall under physiologic responses to stress!! Slide 25 in your lecture
powerpoint
Stress-induced cortisol hormone secretion is associated with:
A. Increased growth hormone level
B. Regulation of the stress response
C. Increased thyroid-stimulating hormone
D. Depressed adrenal gland function
B
You know it's not A because I mentioned in an earlier slide that growth hormone
levels decrease with stress. We didn't mention thyroid-stimulating hormone as one of
the ones associated with the stress repsonse so you can pretty much assume that's
not right. And we know adrenal function is not depressed because ACTH from the
anterior pituitary stimulates the adrenal glands to release cortisol.
Which of the following factors are known to contribute to an individual's ability
to adapt to stress? (Select all that apply.)
, Page 4 of 66
A. Ethnicity
B. Age
C. Socioeconomic status
D. Gender
E. Health status
B, C, D, E
"Ability to adapt to stress" = mediating factors! Slide 28 of this powerpoint
Two people experience the same stressor yet only one is able to cope and
adapt adequately. An example of the person with an increased capacity to
adapt is the one with:
A. A sense of purpose in life
B. Circadian rhythm disruption
C. Age-related renal dysfunction
D. Excessive weight gain or loss
A
Back to mediating factors. Which of these things do you think would help a person
deal with stress? Disruption in sleep cycle (B) will definitely not help, age-related
renal dysfunction (C) is an indicator of poor health status which also would not help,
and excessive weight changes (D) are also likely to cause more stress than alleviate
it
The first circulating immunoglobulin to appear in response to a new antigen is:
A. IgA
B. IgG
C. IgE
D. IgM
