North American Pharmacist Licensure
Examination (NAPLEX) Practice Exam
1. Which organ is primarily responsible for the metabolism of most
medications?
A. Kidney
B. Lung
C. Liver
D. Pancreas
Answer: Liver
Rationale: The liver contains cytochrome P450 enzymes that metabolize the
majority of medications before elimination.
2. Which electrolyte abnormality is commonly associated with loop diuretics?
A. Hyperkalemia
B. Hypokalemia
C. Hypermagnesemia
D. Hypernatremia
Answer: Hypokalemia
Rationale: Loop diuretics increase potassium excretion, leading to hypokalemia.
3. What is the antidote for acetaminophen overdose?
,A. Flumazenil
B. Naloxone
C. Vitamin K
D. N-acetylcysteine
Answer: N-acetylcysteine
Rationale: N-acetylcysteine replenishes glutathione stores and prevents liver
damage.
4. Which insulin has the fastest onset of action?
A. NPH
B. Glargine
C. Detemir
D. Lispro
Answer: Lispro
Rationale: Insulin lispro is a rapid-acting insulin with onset within 15 minutes.
5. Which medication is classified as an ACE inhibitor?
A. Losartan
B. Metoprolol
C. Lisinopril
D. Amlodipine
Answer: Lisinopril
Rationale: Lisinopril inhibits angiotensin-converting enzyme and lowers blood
pressure.
, 6. A patient taking warfarin should have routine monitoring of:
A. aPTT
B. Platelet count
C. Bleeding time
D. INR
Answer: INR
Rationale: INR is used to assess anticoagulation effectiveness and safety of
warfarin therapy.
7. Which antibiotic is associated with tendon rupture?
A. Azithromycin
B. Doxycycline
C. Ciprofloxacin
D. Amoxicillin
Answer: Ciprofloxacin
Rationale: Fluoroquinolones can increase the risk of tendonitis and tendon
rupture.
8. Which medication is used as first-line treatment for hypothyroidism?
A. Methimazole
B. Propylthiouracil
C. Liothyronine
D. Levothyroxine
Answer: Levothyroxine
Rationale: Levothyroxine is synthetic T4 and the standard treatment for
hypothyroidism.
, 9. Which medication should not be crushed?
A. Immediate-release acetaminophen
B. Chewable aspirin
C. Extended-release metoprolol
D. Vitamin C tablet
Answer: Extended-release metoprolol
Rationale: Crushing extended-release products alters drug release and may
cause toxicity.
10.Which pathogen is most commonly associated with peptic ulcer disease?
A. E. coli
B. Helicobacter pylori
C. Streptococcus pneumoniae
D. Staphylococcus aureus
Answer: Helicobacter pylori
Rationale: H. pylori infection is a major cause of peptic ulcer disease.
11.Which medication is considered a statin?
A. Fenofibrate
B. Ezetimibe
C. Atorvastatin
D. Niacin
Answer: Atorvastatin
Examination (NAPLEX) Practice Exam
1. Which organ is primarily responsible for the metabolism of most
medications?
A. Kidney
B. Lung
C. Liver
D. Pancreas
Answer: Liver
Rationale: The liver contains cytochrome P450 enzymes that metabolize the
majority of medications before elimination.
2. Which electrolyte abnormality is commonly associated with loop diuretics?
A. Hyperkalemia
B. Hypokalemia
C. Hypermagnesemia
D. Hypernatremia
Answer: Hypokalemia
Rationale: Loop diuretics increase potassium excretion, leading to hypokalemia.
3. What is the antidote for acetaminophen overdose?
,A. Flumazenil
B. Naloxone
C. Vitamin K
D. N-acetylcysteine
Answer: N-acetylcysteine
Rationale: N-acetylcysteine replenishes glutathione stores and prevents liver
damage.
4. Which insulin has the fastest onset of action?
A. NPH
B. Glargine
C. Detemir
D. Lispro
Answer: Lispro
Rationale: Insulin lispro is a rapid-acting insulin with onset within 15 minutes.
5. Which medication is classified as an ACE inhibitor?
A. Losartan
B. Metoprolol
C. Lisinopril
D. Amlodipine
Answer: Lisinopril
Rationale: Lisinopril inhibits angiotensin-converting enzyme and lowers blood
pressure.
, 6. A patient taking warfarin should have routine monitoring of:
A. aPTT
B. Platelet count
C. Bleeding time
D. INR
Answer: INR
Rationale: INR is used to assess anticoagulation effectiveness and safety of
warfarin therapy.
7. Which antibiotic is associated with tendon rupture?
A. Azithromycin
B. Doxycycline
C. Ciprofloxacin
D. Amoxicillin
Answer: Ciprofloxacin
Rationale: Fluoroquinolones can increase the risk of tendonitis and tendon
rupture.
8. Which medication is used as first-line treatment for hypothyroidism?
A. Methimazole
B. Propylthiouracil
C. Liothyronine
D. Levothyroxine
Answer: Levothyroxine
Rationale: Levothyroxine is synthetic T4 and the standard treatment for
hypothyroidism.
, 9. Which medication should not be crushed?
A. Immediate-release acetaminophen
B. Chewable aspirin
C. Extended-release metoprolol
D. Vitamin C tablet
Answer: Extended-release metoprolol
Rationale: Crushing extended-release products alters drug release and may
cause toxicity.
10.Which pathogen is most commonly associated with peptic ulcer disease?
A. E. coli
B. Helicobacter pylori
C. Streptococcus pneumoniae
D. Staphylococcus aureus
Answer: Helicobacter pylori
Rationale: H. pylori infection is a major cause of peptic ulcer disease.
11.Which medication is considered a statin?
A. Fenofibrate
B. Ezetimibe
C. Atorvastatin
D. Niacin
Answer: Atorvastatin
