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ATI Pharmacology Proctored 2025 Update | 250 Questions and answers 2026 update

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Prepare for your ATI Pharmacology Proctored Exam with this verified 250-question practice study guide. Covers medication administration, drug classifications, adverse effects, interactions, dosage calculations, IV therapy, mental health, and nursing interventions with detailed answers. Perfect for nursing students seeking comprehensive pharmacology exam review.

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ATI Pharmacology Proctor 2025 update b b b b




250 Practice Questions and Answers 2026 update
b b b b b b




250 QUESTIONS b




bA provider prescribes phenobarbital for a client who has a seizure disorder. The medication
b b b b b b b b b b b b b b


has a long half-
b b b


life of 4 days. How many times per day should the nurse expect to administer this medication
b b b b b b b b b b b b b b b b


?


A. One
B. Two
C. Three
D. Fourb-bANS>>A.bOne


(Medications with long half- b b b


lives remain at their therapeutic levels between doses for long periods of time. The nurse shou
b b b b b b b b b b b b b b b


ld expect to administer this medication once a day.)
b b b b b b b b




A staff educator is reviewing medication dosages and factors that influence medication meta
b b b b b b b b b b b b


bolism with a group of nurses at an in-
b b b b b b b b


service presentation. Which of the following factors should the educator include as a reason to
b b b b b b b b b b b b b b


administer lower medication dosages? (Select all that apply.)
b b b b b b b b




A. Increasedbrenalbsecretion
B. Increasedbmedication-metabolizingbenzymes
C. Liverbfailure
D. Peripheralbvascularbdisease
E. Concurrentbusebofbmedicationbthebsamebpathwaybmetabolizesb-bANS>>C.bLiverbfailure
E. Concurrent use of medication the same pathway metabolizes
b b b b b b b b

,C. Liver failure decreases metabolism and thus increases the concentration of a medication. Th
b b b b b b b b b b b b b


is requires decreasing the dosage.
b b b b




E. When the same pathway metabolizes two medications, they compete for metabolism, there
b b b b b b b b b b b b


by increasing the concentration of one or both medications. This requires decreasing the dos
b b b b b b b b b b b b b


age of one or both
b b b b




A nurse is preparing to administer eye drops to a client. Which of the following actions shoul
b b b b b b b b b b b b b b b b


d the nurse take? (Select all that apply.)
b b b b b b b




A. Havebthebclientbliebonbherbside.
B. Askbthebclientbtoblookbupbatbthebceiling.
C. Tellbthebclientbtobblinkbwhenbthebdropsbenterbherbeye.
D. Dropbthebmedicationbintobthebcenterbofbthebclient'sbconjunctivalbsac.
E. Instructbthebclientbtobclosebherbeyebgentlybafterbinstillationb -
b ANS>>B. Ask the client to look up at the ceiling.
b b b b b b b b b



D. Drop the medication into the center of the client's conjunctival sac.
b b b b b b b b b b b



E. Instruct the client to close her eye gently after instillation
b b b b b b b b b b




(B. The client should look upward to keep the drops from falling onto her cornea.
b b b b b b b b b b b b b b



D. The nurse should drop the medication into the
b b b b b b b b



b center of the conjunctival sac to promote distrib
b b b b b b b



ution.
E. The client should close her eye gently to promote distribution of the medication)
b b b b b b b b b b b b b




A nurse is completing discharge teaching for a client who has a new prescription for transderm
b b b b b b b b b b b b b b b


al patches. Which of the following statements should the nurse identify as an indication that t
b b b b b b b b b b b b b b b


he client understands the instructions?
b b b b




A. "I will clean the site with an alcohol swab before I apply the patch."
b b b b b b b b b b b b b b



B. "I will rotate the application sites weekly."
b b b b b b b



C. "I will apply the patch to an area of skin with no hair."
b b b b b b b b b b b b b



D. "I will place the new patch on the site of the old patch. -
b b b b b b b b b b b b b b


ANS>>C. "I will apply the patch to an area of skin with no hair."
b b b b b b b b b b b b b b




30b/b36

,(The client should apply the patch to a hairless area of skin to promote absorption of the medi
b b b b b b b b b b b b b b b b b


cation.)


A nurse reviewing a client's medical record notes a new prescription for verifying the trough
b b b b b b b b b b b b b b b


level of the client's medication. Which of the following actions should the nurse take?
b b b b b b b b b b b b b




31b/b36

, A. Obtainbabbloodbspecimenbimmediatelybpriorbtobadministeringbthebnextbdosebofbmedication.
B. Verifybthatbthebclientbhasbbeenbtakingbthebmedicationbforb24bhrbbeforebobtainingbabbloodbspeci
men.
C. Askbthebclientbtobprovidebaburinebspecimenbafterbthebnextbdosebofbmedication.
D. Administerbthebmedication,andbobtainbabbloodbspecimenb30bminblateb-
ANS>>A. Obtain a blood specimen immediately prior to administering the next dose of medic
b b b b b b b b b b b b b b


ation.


(To verify trough levels of a medication, the nurse should obtain a blood specimen immediatel
b b b b b b b b b b b b b b


y before administering the next dose of medication.)
b b b b b b b




A nurse is preparing a client's medications. Which of the following actions should the nurs
b b b b b b b b b b b b b b


e take in following legal practice guidelines? (Select all that apply.)
b b b b b b b b b b




A. Maintainbskillbcompetency.
B. Determinebthebdosage.
C. Monitorbforbadversebeffects.
D. Safeguardbmedications.
E. Identifybthebclient'sbdiagnosisb-bANS>>A.bMaintainbskillbcompetency.
C. Monitor for adverse effects.
b b b b



D. Safeguard medications.b b




(A.maintainingskill competency and using appropriate administration
techniques are legal responsibilities of the nurse b b b b




C. A nurse is legally responsible for monitoring for side and adverse effects of medication
b b b b b b b b b b b b b b




D. Safeguarding of medications, such as controlled substances, is a legal responsibility of the n
b b b b b b b b b b b b b b


urse)


A nurse reviewing a client's health record notes a new prescription for Lisinopril 10 mg PO on
b b b b b b b b b b b b b b b b


ce every day. The nurse should identify this as which of the following types of prescription?
b b b b b b b b b b b b b b b




A. Single b




32b/b36

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