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What happens when there is a reduction in ATP? - ANSWER-
There is a failure of the Na+ K+ pump and the Na+ Calcium
exchange. This ultimately leads to an intracellular accumulation
of Na+ and Calcium and diffusion of K+ out of the cell. When K+
leaves the cell, more Na+ and water go into the cell which
causes swelling
What happens when oxygen reserves are depleted? -
ANSWER-anaerobic
metabolism
(glycolysis)
Free radical - ANSWER-An electrically uncharged atom(s) that
has an unpaired electron. Having one electron that is unpaired
makes the atom unstable so the atom either has to take an
electron from another molecule or give one away
What is a consequence of leakage of lysosomes during
chemical injury? -
ANSWER-
, Ethanol - ANSWER-Liver enzymes metabolize ethanol to
acetaldehyde which
causes hepatic cellular dysfunction. Peroxisomes help to
detoxify ethanol.
Without peroxisomes the ethanol is turned into fat in the
liver (fatty liver)
Muscular Atrophy - ANSWER-aka Sarcopenia
Stiffness or rigidity of systems
Peripheral vascular resistance increases
Decreased production of HCL and delayed emptying of
stomach
Decreased immune response
Effect of muscular atrophy on Na+ and K+ levels - ANSWER-
F&E: Total body
K+ concentration decreases r/t decreased cellular mass
An increased Na+/K+ ratio suggests that the decreased cellular
mass is accompanied by an increased extracellular
compartment
What are the s/sx of dehydration (decreased perfusion) -
ANSWER-headache, thirst, dry skin and mucous membranes,
weight loss, decreased or concentrated urine, tachycardia,
weak pulses, postural hypotension
what triggers thirst - ANSWER-osmoreceptors are activated
by increase in