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NURS 5334 ACTUAL PHARM STUDY GUIDE
EXAM WITH CORRECT ANSWERS, RATIONALES
NEWEST 2026 EXAM VERIFIED 100 % 100%
VERIFIED | GRADED A+ | VERIFIED TEXAS BON
PRESCRIPTIVE RULES
Designed for advanced practice nursing students, this resource features Next
Generation NCLEX (NGN)-style questions focused on pharmacology principles and
Texas Board of Nursing (BON) prescriptive authority rules, complete with verified
answers and detailed expert rationales.
Topic 1: Pharmacokinetics & Pharmacodynamics
Question 1
A drug with high first-pass metabolism is administered orally. What is the most
likely result?
A. Increased bioavailability
B. Reduced bioavailability
C. Increased half-life
D. Increased protein binding
Answer: B
Rationale: First-pass metabolism occurs in the liver before the drug reaches
systemic circulation, reducing bioavailability.
Question 2
Which organ is primarily responsible for drug excretion?
A. Liver
B. Kidney
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C. Lung
D. Pancreas
Answer: B
Rationale: Most drugs and metabolites are eliminated through renal filtration and
secretion.
Question 3
A highly protein-bound drug is given with another highly protein-bound medication.
What may occur?
A. Increased therapeutic effect
B. Decreased absorption
C. Drug displacement and toxicity
D. Faster elimination
Answer: C
Rationale: Competition for protein-binding sites can increase free drug
concentration.
Question 4
An agonist drug:
A. Blocks receptors
B. Activates receptors
C. Destroys receptors
D. Prevents metabolism
Answer: B
Rationale: Agonists bind and activate receptors to produce a physiological
response.
Question 5
A patient with severe renal impairment requires dose adjustment because:
A. Absorption increases
B. Metabolism increases
C. Drug excretion decreases
NURS 5334 ACTUAL PHARM STUDY GUIDE
EXAM WITH CORRECT ANSWERS, RATIONALES
NEWEST 2026 EXAM VERIFIED 100 % 100%
VERIFIED | GRADED A+ | VERIFIED TEXAS BON
PRESCRIPTIVE RULES
Designed for advanced practice nursing students, this resource features Next
Generation NCLEX (NGN)-style questions focused on pharmacology principles and
Texas Board of Nursing (BON) prescriptive authority rules, complete with verified
answers and detailed expert rationales.
Topic 1: Pharmacokinetics & Pharmacodynamics
Question 1
A drug with high first-pass metabolism is administered orally. What is the most
likely result?
A. Increased bioavailability
B. Reduced bioavailability
C. Increased half-life
D. Increased protein binding
Answer: B
Rationale: First-pass metabolism occurs in the liver before the drug reaches
systemic circulation, reducing bioavailability.
Question 2
Which organ is primarily responsible for drug excretion?
A. Liver
B. Kidney
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C. Lung
D. Pancreas
Answer: B
Rationale: Most drugs and metabolites are eliminated through renal filtration and
secretion.
Question 3
A highly protein-bound drug is given with another highly protein-bound medication.
What may occur?
A. Increased therapeutic effect
B. Decreased absorption
C. Drug displacement and toxicity
D. Faster elimination
Answer: C
Rationale: Competition for protein-binding sites can increase free drug
concentration.
Question 4
An agonist drug:
A. Blocks receptors
B. Activates receptors
C. Destroys receptors
D. Prevents metabolism
Answer: B
Rationale: Agonists bind and activate receptors to produce a physiological
response.
Question 5
A patient with severe renal impairment requires dose adjustment because:
A. Absorption increases
B. Metabolism increases
C. Drug excretion decreases
