What is neo-adjuvant chemotheapy?
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MAIN GOAL: reduce the size of the tumor
-- Therapy added on board to existing chemo to eliminate metastases
and/or reduce the size of the primary tumor b/f surgery and/or radiation
Examples of Non-classic alkylating agents
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, -- procarbazine (MAO inhibitor) and dacarbazine
Pro-da lost the car in bazy and now not classy enough for Alkyl agents
Proteosome inhibitors: MOA, examples adverse effects
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MOA:
-- reversible inhibitor of 26s proteosome
-- inhibits breakdown of ubiquinated cellular proteins including NFkB
-- upregulation of apoprosis in lymphomas
-- stabilizes tumor suppressors
Examples;
Bortezomib- parenteral only
AE:
-- peripheral neuropathy in 30% of the cases
What is primary induction chemotherapy?
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-- Presentation of advanced disease-- mostly palliative
- disease no longer responds to radiation/surgical interventions
broad categories of natural products anticancer drugs
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, -- Microtubule inhibitors
-- Topoisomerase inhibitors
-- anti-tumor antobiotics
Side effects of flouropyrimidines
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same as common chemotherapy SE +
hand foot synrome: redness, swelling tingling pain
callus formation, cracked and peeling skin
--Tx; cortecosteroids
Mnemonic: walking on the flour with hand and feet gives you calluses
Purine antagonists; MOA and examples
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MOA:
-- inhibit de-novo purine synthesis
Examples:
-- 6-mercaptopurine and thioguanine
Toxicity of Alkylating agents
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Give this one a try later!
MAIN GOAL: reduce the size of the tumor
-- Therapy added on board to existing chemo to eliminate metastases
and/or reduce the size of the primary tumor b/f surgery and/or radiation
Examples of Non-classic alkylating agents
Give this one a try later!
, -- procarbazine (MAO inhibitor) and dacarbazine
Pro-da lost the car in bazy and now not classy enough for Alkyl agents
Proteosome inhibitors: MOA, examples adverse effects
Give this one a try later!
MOA:
-- reversible inhibitor of 26s proteosome
-- inhibits breakdown of ubiquinated cellular proteins including NFkB
-- upregulation of apoprosis in lymphomas
-- stabilizes tumor suppressors
Examples;
Bortezomib- parenteral only
AE:
-- peripheral neuropathy in 30% of the cases
What is primary induction chemotherapy?
Give this one a try later!
-- Presentation of advanced disease-- mostly palliative
- disease no longer responds to radiation/surgical interventions
broad categories of natural products anticancer drugs
Give this one a try later!
, -- Microtubule inhibitors
-- Topoisomerase inhibitors
-- anti-tumor antobiotics
Side effects of flouropyrimidines
Give this one a try later!
same as common chemotherapy SE +
hand foot synrome: redness, swelling tingling pain
callus formation, cracked and peeling skin
--Tx; cortecosteroids
Mnemonic: walking on the flour with hand and feet gives you calluses
Purine antagonists; MOA and examples
Give this one a try later!
MOA:
-- inhibit de-novo purine synthesis
Examples:
-- 6-mercaptopurine and thioguanine
Toxicity of Alkylating agents
Give this one a try later!
