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Samenvatting HO 4 - Zalven en Crèmes | Galenica | Artesis Hogeschool

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Dit hogeschooldocument behandelt zalven en crèmes (half-vaste preparaten) uit het Galenica-vak aan Artesis Hogeschool Antwerpen. Het dekt definities, werkingsmechanismen, huidopbouw, samenstelling van farmaca en hulpstoffen, verschillende zalfbases, en bereiding van oplossings- en suspensiezalven/crèmes. Ideaal voor examenvoorbereiding in biomedische laboratoriumtechnieken met gedetailleerde formuleringen en praktische bereidsvoorschriften.

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HO 4 -Zalven en Crèmes (( < half-vaste preparaten )
Definities

ZALF (1 fase)

• Hydrofobe, waterabsorberende, hydrofiele

• GM opgelost of gesuspendeerd in zalfbasis

CREME (2 fasen: lipofiele fase + waterfase)

• O/W of W/O, (emulgatoren)

• GM opgelost of gesuspendeerd in crèmebasis

Werking

Lokaal

Systemisch

Opname farmacon in huid afhankelijk van

• Fysicochemische eigenschappen farmacon

• Samenstelling vehiculum

• Toestand van huid, plaats op lichaam, leeftijd,..

Farmaceutische versus biologische beschikbaarheid.

Opbouw huid Epidermis bestaat uit :

stratum corneum of hoornlaag

stratum lucidum of glanslaag

stratum granulosum of korrellaag

stratum spinosum of
stekelcellenlaag

stratum basale of onderste laag

, Transport • Grootste barriëre: stratum
corneum – watergehalte
slechts 20%

• Beste permeatie:
lipofiel/hydrofiel




Samenstelling

R/ Farmaca

Penetratiebevorderaar

Antioxydans

Bewaarmiddel

Zalfbasis of crèmebasis




Samenstelling: Farmaca

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Uploaded on
June 2, 2026
Number of pages
8
Written in
2024/2025
Type
SUMMARY

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maud17 Plantijn Hogeschool van de provincie Antwerpen
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