Experiment 3 & 4: Aspirin Synthesis and Analysis with correct answers 100% 2026

Experiment 3 & 4: Aspirin Synthesis and Analysis with correct answers 100% 2026 Experiment 3 Key Ideas - Correct Answer - Salycilic acid - Pka is low - Esterification Reaction- Removal of trhe carboxylic acid functional group to an ester to form ASA - TLC- -Mobile Phase- Eluent - mobile phase moves up the plate based on capillary action - the compounds that interact more strongly with the polar silica will not move up the plate as much - Compounds that react less with the plate will move up more - non polar moves up higher -changing the solvent can affect how the compunds move up the plate - Stationary Phase- silica plate Objective - Correct Answer Understand the synthesis of ASA from salicylic acid (esterification) in aspirin. Phosphoric acid is a catalyst for this reaction that is completed once all solid disappears. Thin layer chromatography (TLC) is a technique that separates compounds based on competing intermolecular interactions of the polar silica plate and less polar solvent. Determine the purity and concentration of the aspirin product with 3 techniques: melting point, reaction with FeCl3, and absorbance spectrum Why must TLC analysis be performed on all the known components of the chemical reaction before conducting the synthesis? - Correct Answer TLC analysis must be performed on all known components of the chemical reaction before conduction synthesis because to be able to recognize the products of the chemicals once the analysis has been completed. Describe the polarity of this solution. Why is this mixture a more effective mobile phase compared to pure ethyl acetate or pure ethanol? - Correct Answer The mobile phase is more effective compared to pure ethyl acetate or pure ethanol since ethanol is more polar compared to ethyl acetate, therefore the mixture is stronger. What feature in the molecular structures of both SA and ASA, Figure 1 and 2 of the manual introduction, allows both compounds to be visualized under UV light? - Correct Answer The feature in the molecular structures of both SA and ASA that allows both compounds to be visualized under UV light is the benzene ring that is connected to the carboxylic acid. Why can the Rf values NOT be calculated in this situation? (SCREENSHOT IN DATA AND CALCULATIONS) - Correct Answer Rf values cannot be calculated in this situation because when the filter paper and the TLC plate touch each other in the chamber the solution gets pulled toward the filter paper, therefore, the Rf values would be incorrect.