MLS Review Book
Immunology Questions
2026 | Practice Q&A &
Study Guide
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Updated 2026 Questions and Answers
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,4. T cells travel from the bone marrow to the thymus B. Maturation and selection occur in the cortex;
for maturation. What is the correct order of the migration to the medulla; release of mature
maturation sequence for T cells in the thymus? T cells to secondary lymphoid organs
A. Bone marrow to the cortex; after thymic
education, released back to peripheral circulation
B. Maturation and selection occur in the cortex;
migration to the medulla; release of mature
T cells to secondary lymphoid organs
C. Storage in either the cortex or medulla; release of
T cells into the peripheral circulation
D. Activation and selection occur in the medulla;
mature T cells are stored in the cortex until
activated by antigen
Which cluster of differentiation (CD) marker B. CD2
appears during the first stage of T-cell
development and remains present as an
identifying marker for T cells?
A. CD1
B. CD2
C. CD3
D. CD4 or CD8
6. Which markers are found on mature, peripheral D. CD2, CD3, CD4
helper T cells?
A. CD1, CD2, CD4
B. CD2, CD3, CD8
C. CD1, CD3, CD4
D. CD2, CD3, CD4
7. Which T cell expresses the CD8 marker and acts C. T cytotoxic
specifically to kill tumors or virally infected cells?
A. Helper T
B. T suppressor
C. T cytotoxic
D. T inducer/suppressor
8. How are cytotoxic T cells (TC cells) and natural B. Effective against virally infected cells
killer (NK) cells similar?
A. Require antibody to be present
B. Effective against virally infected cells
C. Recognize antigen in association with HLA class
II markers
D. Do not bind to infected cells
9. What is the name of the process by which C. Chemotaxis
phagocytic cells are attracted to a substance
such as a bacterial peptide?
A. Diapedesis
B. Degranulation
C. Chemotaxis
D. Phagotaxis
, 10. All of the following are immunologic functions A. Induction of an antiviral state
of complement except:
A. Induction of an antiviral state
B. Opsonization
C. Chemotaxis
D. Anaphylatoxin formation
11. Which complement component is found in both D. C3
the classic and alternative pathways?
A. C1
B. C4
C. Factor D
D. C3
12. Which immunoglobulin(s) help(s) initiate the C. IgG and IgM
classic complement pathway?
A. IgA and IgD
B. IgM only
C. IgG and IgM
D. IgG only
13. How is complement activity destroyed in vitro? A. Heating serum at 56°C for 30 min
A. Heating serum at 56°C for 30 min
B. Keeping serum at room temperature of 22°C for
1 hour
C. Heating serum at 37°C for 45 min
D. Freezing serum at 0°C for 24 hours
14. What is the purpose of C3a, C4a, and C5a, the B. To cause increased vascular permeability,
split products of the complement cascade? contraction of smooth muscle, and release of
A. To bind with specific membrane receptors of histamine from basophils
lymphocytes and cause release of cytotoxic
substances
B. To cause increased vascular permeability,
contraction of smooth muscle, and release of
histamine from basophils
C. To bind with membrane receptors of
macrophages to facilitate phagocytosis and the
removal of debris and foreign substances
D. To regulate and degrade membrane cofactor
protein after activation by C3 convertase
15. Which region of the immunoglobulin molecule A. Fab
can bind antigen?
A. Fab
B. Fc
C. CL
D. CH
Immunology Questions
2026 | Practice Q&A &
Study Guide
|Graded A+ | Guaranteed
success|
Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales
Included
,4. T cells travel from the bone marrow to the thymus B. Maturation and selection occur in the cortex;
for maturation. What is the correct order of the migration to the medulla; release of mature
maturation sequence for T cells in the thymus? T cells to secondary lymphoid organs
A. Bone marrow to the cortex; after thymic
education, released back to peripheral circulation
B. Maturation and selection occur in the cortex;
migration to the medulla; release of mature
T cells to secondary lymphoid organs
C. Storage in either the cortex or medulla; release of
T cells into the peripheral circulation
D. Activation and selection occur in the medulla;
mature T cells are stored in the cortex until
activated by antigen
Which cluster of differentiation (CD) marker B. CD2
appears during the first stage of T-cell
development and remains present as an
identifying marker for T cells?
A. CD1
B. CD2
C. CD3
D. CD4 or CD8
6. Which markers are found on mature, peripheral D. CD2, CD3, CD4
helper T cells?
A. CD1, CD2, CD4
B. CD2, CD3, CD8
C. CD1, CD3, CD4
D. CD2, CD3, CD4
7. Which T cell expresses the CD8 marker and acts C. T cytotoxic
specifically to kill tumors or virally infected cells?
A. Helper T
B. T suppressor
C. T cytotoxic
D. T inducer/suppressor
8. How are cytotoxic T cells (TC cells) and natural B. Effective against virally infected cells
killer (NK) cells similar?
A. Require antibody to be present
B. Effective against virally infected cells
C. Recognize antigen in association with HLA class
II markers
D. Do not bind to infected cells
9. What is the name of the process by which C. Chemotaxis
phagocytic cells are attracted to a substance
such as a bacterial peptide?
A. Diapedesis
B. Degranulation
C. Chemotaxis
D. Phagotaxis
, 10. All of the following are immunologic functions A. Induction of an antiviral state
of complement except:
A. Induction of an antiviral state
B. Opsonization
C. Chemotaxis
D. Anaphylatoxin formation
11. Which complement component is found in both D. C3
the classic and alternative pathways?
A. C1
B. C4
C. Factor D
D. C3
12. Which immunoglobulin(s) help(s) initiate the C. IgG and IgM
classic complement pathway?
A. IgA and IgD
B. IgM only
C. IgG and IgM
D. IgG only
13. How is complement activity destroyed in vitro? A. Heating serum at 56°C for 30 min
A. Heating serum at 56°C for 30 min
B. Keeping serum at room temperature of 22°C for
1 hour
C. Heating serum at 37°C for 45 min
D. Freezing serum at 0°C for 24 hours
14. What is the purpose of C3a, C4a, and C5a, the B. To cause increased vascular permeability,
split products of the complement cascade? contraction of smooth muscle, and release of
A. To bind with specific membrane receptors of histamine from basophils
lymphocytes and cause release of cytotoxic
substances
B. To cause increased vascular permeability,
contraction of smooth muscle, and release of
histamine from basophils
C. To bind with membrane receptors of
macrophages to facilitate phagocytosis and the
removal of debris and foreign substances
D. To regulate and degrade membrane cofactor
protein after activation by C3 convertase
15. Which region of the immunoglobulin molecule A. Fab
can bind antigen?
A. Fab
B. Fc
C. CL
D. CH
