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CJE Pharmacology Review NR293- Pharmacology- Week 1/Unit... NR 293: week 1 Quizlet
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What is the main goal of the endocrine system? For PHYSIOLOGIC STABILITY (HOMEOSTASIS)
- Every cell and organ in the body is influenced by this system
What are hormones? The "CHEMICAL LANGUAGE" of the endocrine system
- Natural substances
- Secreted into the bloodstream and travels through the blood to the site of
action
Hypothalamus Part of the CNS
- MASTER
- THERMOSTAT
Pituitary Gland Has two lobes
- Anterior pituitary (adenohypohysis)
- Posterior pituitary (neurohypophysis)
They govern all bodily functions (hormones and negative feedback loop)
Negative Feedback Loop Activity of the endocrine system regulated by this system of surveillance and
signaling based on the body's needs
- Regulates hormone secretion
What are the anterior pituitary drugs? Cosyntopin
Somatopin
Octreotide
What are the posterior pituitary drugs? Vasopressin
Desmopressin
, Cosyntopin (Cortosyn) STIMULATES RELEASE OF CORTISOL FROM THE ADRENAL CORTEX
- Anti-inflammatory
- DIAGNOSIS OF ADRENOCORTICAL INSUFFICIENCY
- Wasting associated with human immunodeficiency virus infection
- Promotes renal retention of SODIUM, WHICH CAN RESULT IN EDEMA AND
HYPERTENSION
Somatropin & Somatem Recombinantly made GROWTH HORMONE (GH)
- Stimulates skeletal growth in patients with deficient GH, such as HYPOPITUITARY
DWARFISM
Octreotide (Sandostatin) CARCINOID TUMORS SECRETE VIP (vasoactive intestinal polypeptide)
- VIP causes PROFUSE, WATERY DIARRHEA
- Octreotide reduces diarrhea, flushing, and life-threatening HYPOTENSION that
may occur with a CARCINOID CRISIS
Vasopressin & Desmopressin Mimic the action of ANTIDIURETIC HORMONE
- Increase WATER REABSORPTION in the distal tubules and collecting ducts of
nephrons that concentrate urine
- REDUCES WATER EXCRETION by up to 90%
- Used in treatment with DIABETES INSIPIDUS
Indications for Vasopressin ADH - Diabetes Insipidus
- POTENT VASOCONSTRICTOR
- HYPOTENSIVE EMERGENCIES (Vasodilatory Shock - Septic Shock)
- ADVANCES CARDIAC LIFE SUPPORT (ACLS) - PULSELESS CARDIAC ARREST
- Used to STOP BLEEDING OF ESOPHAGEAL VARICES
Indications for Desmopressin DDVAP
- Dose-dependent increase in the plasma levels of:
- Factor VIII (antihemophilic factor)
- Von Willebrand factor
- Tissue plasminogen activator (HELPS WITH CLOTTING)
- Management of NOCTURNAL ENURESIS
Nursing Implications (Octreotide - Sandostatin) - May impair GALLBLADDER FUNCTION
- Instruct patient to report ABDOMINAL PAIN
- Use with caution on patients with RENAL impairment
- Monitor glucose levels in patients without and with diabetes
- Can be given intravenously, intramuscularly, or subcutaneously
Thyroid Gland Secretes 3 hormones
- Essential for proper regulation of metabolism
- Located near parathyroid gland
- Responsible for maintaining levels of calcium in the extracellular fluid
Thyroid Gland Hormones Thyroxine (T4)
Triidothryonine (T3)
Calcitonin
Primary Hypothyroidism Abnormality in the THYROID GLAND ITSELF