MICB 4131 EXAM 1 QUESTIONS AND VERIFIED
ANSWERS
vaccination - Answers - -The deliberate exposure to infectious agent to induce immunity
-diverse IS to recognize different pathogens in different locations
pathogens - Answers - viruses, bacteria, fungi, parasite
Leukocytes - Answers - white blood cells, fight infection
Lymphocytes - Answers - b and t cells (adaptive)
PMN (polymorphonuclear leukocytes) - Answers - neutrophils (produced in bone
marrow, only released if ), eosinophils, basophils, granulocytes
-short lived
Monocytes - Answers - precursors of tissue macrophages
dendritic cells - Answers - antigen-presenting cells in the skin, bridges innate and
adaptive immune systems
where are the vast majority of cells of immune systems - Answers - hematopoietic
pluripotent stem cells in bone marrow
-myeloid and lymphoid
common myeloids - Answers - monocytes, neutrophils, basophils, eosinophils,
(dendritic)
Lympoid progenitor - Answers - B, T, and NK cells (dendritic)
where do b cells mature - Answers - bone marrow
Where do T cells mature? - Answers - thymus
Cytokines - Answers - proteins secreted by cells
Chemokines - Answers - ability to attract other cells and induce activation/arrest during
leukocyte extravasation
CC
CXC
which chemokine attracts neutrophils to sites of inflammation - Answers - CXCL8 (IL-8)
, CCL19/21 - Answers - receptor for CCR7
primary/central lymphoid organs - Answers - bone marrow and thymus
where cells generate and develop
secondary lymphoid organs - Answers - spleen and lymph nodes
activation of cells
innate immune system - Answers - -immediate,
-not specific for one pathogen
-no learning process or memory
adaptive immune system - Answers - -slower response
-more specific immune response (exact epitopes)
-memory
-needs innate to initiate
innate immunity - Answers - mechanisms that protects host from infection
-temp
-skin
-commensal flora
-pH
anti-microbial proteins
specialized innate immune cells that respond to microbes - Answers - neutrophils,
eosinophils, basophils, macrophages, dendritic cells, mast cells, NK
what do neutrophils, macrophages, and dendritic cells have in common? - Answers - -
able to phagocytose pathogens (phagocytes)
-neutrophils then destroy it
-dendritic cell: best at destroying foreign material and presenting antigen
where do macrophages live - Answers - near epithelial surfaces
where do dendritic cells lives - Answers - lymphoid tissue
-process ingested microbes
where do neutrophils stay - Answers - migrate through blood to infection sites, eat and
kill bacteria, and then die
Specificity inherited in the genome - Answers - innate
expressed by all cells of a particular type - Answers - innate
triggers immediate response - Answers - innate
ANSWERS
vaccination - Answers - -The deliberate exposure to infectious agent to induce immunity
-diverse IS to recognize different pathogens in different locations
pathogens - Answers - viruses, bacteria, fungi, parasite
Leukocytes - Answers - white blood cells, fight infection
Lymphocytes - Answers - b and t cells (adaptive)
PMN (polymorphonuclear leukocytes) - Answers - neutrophils (produced in bone
marrow, only released if ), eosinophils, basophils, granulocytes
-short lived
Monocytes - Answers - precursors of tissue macrophages
dendritic cells - Answers - antigen-presenting cells in the skin, bridges innate and
adaptive immune systems
where are the vast majority of cells of immune systems - Answers - hematopoietic
pluripotent stem cells in bone marrow
-myeloid and lymphoid
common myeloids - Answers - monocytes, neutrophils, basophils, eosinophils,
(dendritic)
Lympoid progenitor - Answers - B, T, and NK cells (dendritic)
where do b cells mature - Answers - bone marrow
Where do T cells mature? - Answers - thymus
Cytokines - Answers - proteins secreted by cells
Chemokines - Answers - ability to attract other cells and induce activation/arrest during
leukocyte extravasation
CC
CXC
which chemokine attracts neutrophils to sites of inflammation - Answers - CXCL8 (IL-8)
, CCL19/21 - Answers - receptor for CCR7
primary/central lymphoid organs - Answers - bone marrow and thymus
where cells generate and develop
secondary lymphoid organs - Answers - spleen and lymph nodes
activation of cells
innate immune system - Answers - -immediate,
-not specific for one pathogen
-no learning process or memory
adaptive immune system - Answers - -slower response
-more specific immune response (exact epitopes)
-memory
-needs innate to initiate
innate immunity - Answers - mechanisms that protects host from infection
-temp
-skin
-commensal flora
-pH
anti-microbial proteins
specialized innate immune cells that respond to microbes - Answers - neutrophils,
eosinophils, basophils, macrophages, dendritic cells, mast cells, NK
what do neutrophils, macrophages, and dendritic cells have in common? - Answers - -
able to phagocytose pathogens (phagocytes)
-neutrophils then destroy it
-dendritic cell: best at destroying foreign material and presenting antigen
where do macrophages live - Answers - near epithelial surfaces
where do dendritic cells lives - Answers - lymphoid tissue
-process ingested microbes
where do neutrophils stay - Answers - migrate through blood to infection sites, eat and
kill bacteria, and then die
Specificity inherited in the genome - Answers - innate
expressed by all cells of a particular type - Answers - innate
triggers immediate response - Answers - innate
